%0 Journal Article
%@ 2088 4559
%A Lusi, Putri Dwita
%A Ema, Dewanti
%A Vera, Ladeska
%A Sediarso, Sediarso
%A Adnan, Adnan
%A Rahma, Wulan Sari
%A UHAMKA,
%D 2018
%F repository:602
%I pharmaciana
%J Pharmaciana
%N 2
%P 217-224
%T Neuropharmacological activity of nut grass (Cyperus Rotundus L.) rhizome fraction
%U http://repository.uhamka.ac.id/id/eprint/602/
%V 8
%X The flavonoids content of Cyperus rotundus rhizomes is presumed to show activities on a central nervous system involving GABAergik. This research aimed to further investigate the neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring their hypnotic-sedative and anticonvulsant activities. The exploratory behavior test was performed using the hole-board method, while the motor coordination was assessed using the rotarod test. The results showed that the 70% ethanol fraction of Cyperus rotundus rhizome exhibited significant neuropharmacological activities (p < 0.05). Among the three fractions tested in this research (i.e., ethanol, ethyl acetate, and n-hexane), the ethanol fraction showed the best hypnotic-sedative and anticonvulsant activities. The ethanol fraction of Cyperus rotundus rhizome could shorten the duration of HLE equal to sodium valproate and potentiate phenobarbital-induced sleep by reducing the onset and prolonging the duration of sleep. The highest dose of the 70% ethanol fraction of Cyperus rotundus rhizome (356.7 mg/kg) displayed the best anxiolytic activity, resembling that of diazepam (p>0.05). In conclusion, Cyperus rotundus rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetic drugs.