@article{repository602,
         journal = {Pharmaciana},
          volume = {8},
           pages = {217--224},
          number = {2},
            year = {2018},
       publisher = {pharmaciana},
           title = {Neuropharmacological activity of nut grass (Cyperus Rotundus L.) rhizome fraction},
             url = {http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/217/pdf\%5f82},
            issn = {2088 4559},
        abstract = {The flavonoids content of Cyperus rotundus rhizomes is presumed to show activities on a central nervous system involving GABAergik. This research aimed to further investigate the neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring their hypnotic-sedative and anticonvulsant activities. The exploratory behavior test was performed using the hole-board method, while the motor coordination was assessed using the rotarod test. The results showed that the 70\% ethanol fraction of Cyperus rotundus rhizome exhibited significant neuropharmacological activities (p {\ensuremath{<}} 0.05). Among the three fractions tested in this research (i.e., ethanol, ethyl acetate, and n-hexane), the ethanol fraction showed the best hypnotic-sedative and anticonvulsant activities. The ethanol fraction of Cyperus rotundus rhizome could shorten the duration of HLE equal to sodium valproate and potentiate phenobarbital-induced sleep by reducing the onset and prolonging the duration of sleep. The highest dose of the 70\% ethanol fraction of Cyperus rotundus rhizome (356.7 mg/kg) displayed the best anxiolytic activity, resembling that of diazepam (p{\ensuremath{>}}0.05). In conclusion, Cyperus rotundus rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetic drugs.},
          author = {Lusi, Putri Dwita and Ema, Dewanti and Vera, Ladeska and Sediarso, Sediarso and Adnan, Adnan and Rahma, Wulan Sari}
}