<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "In Silico Study of Pyrazolylaminoquinazoline Toxicity by Lazar, Protox, and Admet Predictor"^^ . "Pyrazolylaminoquinazoline is obtained from synthetic AZD4547 and can inhibit kinase activity in recombinant\r\nfibroblast growth factor receptor (FGFR) in vitro. The objective of this study was to obtain high activity and low\r\ntoxicity pyrazolylaminoquinazoline derivatives in silico. The 2-dimensional structures were generated using the\r\nChemDraw application. The Lazar application was used to predict endpoint carcinogenicity, maximum daily dose,\r\nand mutagenicity. The ProTox application was used for endpoint LD50 and toxicity classes, while the ADMET\r\napplication was used for endpoint hepatotoxicity, with reproductive system disorders, and endocrine. Based on the\r\nscoring from the three software applications, two compounds were identified as being active against FGFR 2, with no\r\ncarcinogenic or toxic effects on the liver, endocrine system, and the reproductive system, but they were predicted to\r\nhave mutagenic effects. These compounds were V29 (N-(5-(3,5-dimethoxy phenethyl -1H-pyrazol-3-yl)-7(octahydro-\r\n2H-pyrido[1,2-a]pyrazine-2-yl) quinazoline-4-amine), with an IC50 of 0.2 ± 0.1 nM and a toxicity score of 1027, and\r\nV32 (N-(5-(3,5-dimethoxy phenethyl)-1H-pyrazol-3-yl)-7-(4-(dimethylamino)piperidine-1-yl)quinazoline-4-amine),\r\nwith an IC50 of 0.3 ± 0.1 nM and a toxicity score of 1024."^^ . . "8" . . "Journal of Applied Pharmaceutical Science"^^ . . . "Journal of Applied Pharmaceutical Science"^^ . . . "22313354" . . . . . . . . . . "Supandi"^^ . "Supandi Supandi"^^ . "Supandi Supandi Supandi"^^ . . "Yeni"^^ . "Yeni"^^ . "Yeni Yeni"^^ . . "UHAMKA"^^ . . . . . . . "In Silico Study of Pyrazolylaminoquinazoline Toxicity by Lazar, Protox, and Admet Predictor (Text)"^^ . . . "Japs-accepted.pdf"^^ . . . "In Silico Study of Pyrazolylaminoquinazoline Toxicity by Lazar, Protox, and Admet Predictor (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "In Silico Study of Pyrazolylaminoquinazoline Toxicity by Lazar, Protox, and Admet Predictor (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "In Silico Study of Pyrazolylaminoquinazoline Toxicity by Lazar, Protox, and Admet Predictor (Other)"^^ . . . . . . "preview.jpg"^^ . . . "In Silico Study of Pyrazolylaminoquinazoline Toxicity by Lazar, Protox, and Admet Predictor (Other)"^^ . . . . . . "medium.jpg"^^ . . . "In Silico Study of Pyrazolylaminoquinazoline Toxicity by Lazar, Protox, and Admet Predictor (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #575 \n\nIn Silico Study of Pyrazolylaminoquinazoline Toxicity by Lazar, Protox, and Admet Predictor\n\n" . "text/html" . . . "RS Pharmacy and materia medica"@en . .