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(2025). 6-Gingerol\r\nInhibits Ferroptosis in Endothelial Cells in Atherosclerosis by Activating the\r\nNRF2/HO-1 Pathway. Applied Biochemistry and Biotechnology, 197(6),\r\n3890\u20133906. https://doi.org/10.1007/s12010-025-05214-3\r\nWang, T., Zheng, L., Liu, X., & Zhao, M. (2023). Sea cucumber (Holothuria nobilis)\r\nhydrolysates improve diabetic nephropathy via suppression of oxidative stress\r\nin high-fat diet/streptozotocin-induced diabetic rats. Journal of Functional\r\nFoods, 106, 105589. https://doi.org/10.1016/j.jff.2023.105589\r\nWargasetia, T. L., Ratnawati, H., Widodo, N., & Widyananda, M. H. (2023a). Antioxidant\r\nand Anti-inflammatory Activity of Sea Cucumber ( Holothuria\r\nscabra) Active Compounds against KEAP1 and iNOS Protein. Bioinformatics\r\nand Biology Insights, 17. https://doi.org/10.1177/11779322221149613\r\nWen, L., Li, R., Zhao, Y. C., Yang, J. Y., X. Y, Xue, C. H., & Wang, Y. M. (2022).\r\ncomparative study of the anti-obesity effects of dietary sea cucumber saponins\r\nand energy restriction in response to weight loss and weight regain in mice.\r\nMarine Drugs, 20(10), 629.\r\nWHO. (2025, May 7). Obesity and overweight. World Health Organization.\r\nhttps://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight\r\nXiao, W., & Loscalzo, J. (2020). Metabolic Responses to Reductive Stress. Antioxidants\r\n& Redox Signaling,\r\n32(18), 1330\u2013 1347. https://doi.org/10.1089/ars.2019.7803\r\nYang, K., Lu, Y., Yue, Z., Jin, S., Wang, P., Liu, C., Wang, L., Yin, Q., Dang, X.,\r\nGuo, H., & Chang, J. (2024). 6-Gingerol activates the Nrf2 signaling pathway\r\nto alleviate hydrogen peroxide induced oxidative stress on primary chicken\r\nembryo hepatocytes. Journal of Functional Foods, 122, 106535.\r\nhttps://doi.org/10.1016/j.jff.2024.106535\r\nYao, J., Wu, D., & Qiu, Y. (2022). Adipose tissue macrophage in obesity-associated\r\nmetabolic diseases. Frontiers in Immunology,\r\n13. https://doi.org/10.3389/fimmu.2022.977485\r\nZhao, Y., Wang, H., Zhou, J., & Shao, Q. (2022). Glutathione Peroxidase GPX1 and\r\nIts Dichotomous Roles in Cancer. Cancers 2022, Vol. 14, Page 2560, 14(10),\r\n2560. https://doi.org/10.3390/CANCERS14102560",
      "rev_number": 8,
      "thesis_type": "bachelor",
      "ispublished": "pub",
      "abstract": "Obesitas merupakan kondisi patologis yang ditandai oleh akumulasi jaringan adiposa berlebih\r\ndan dikaitkan dengan peningkatan produksi reactive oxygen species (ROS) yang\r\nmemicu stres oksidatif dan penurunan kadar glutathione (GSH). Holothuria atra merupakan\r\nspesies teripang yang mengandung senyawa bioaktif yang diduga mampu memodulasi\r\nkapasitas antioksidan endogen. Penelitian ini bertujuan untuk mengevaluasi efek pemberian\r\nekstrak H. atra terhadap kadar GSH aorta pada tikus obesitas yang diinduksi high\r\nfat diet (HFD). Penelitian eksperimental in vivo ini menggunakan tikus jantan Sprague\r\nDawley yang dibagi menjadi tiga kelompok: kelompok Pakan Normal, kelompok Pakan\r\nHFD, dan kelompok Pakan HFD+Ekstrak H. atra dengan dosis 300 mg/kgBB selama 6\r\nminggu. Kadar GSH aorta diukur menggunakan metode ELISA. Hasil penelitian menunjukkan\r\nbahwa kadar GSH aorta kelompok Pakan HFD+Ekstrak H. atra secara signifikan\r\nlebih tinggi dibandingkan kelompok Pakan HFD (3,36 \u00b1 0,15 \u03bcg/mL vs 1,70 \u00b1 0,02 \u03bcg/mL;\r\np < 0,001), meskipun belum mencapai kadar kelompok Pakan Normal (10,38 \u00b1 1,08\r\n\u03bcg/mL). Temuan ini mengindikasikan bahwa ekstrak H. atra berpotensi meningkatkan kapasitas\r\nantioksidan endogen pada jaringan aorta tikus obesitas.\r\nKata kunci: glutathione, high fat diet, Holothuria atra, obesitas, Sprague Dawley",
      "divisions": [
        11201
      ],
      "datestamp": "2026-09-16 09:23:19",
      "title": "SKRIPSI-2210015037-RARA NADIKA-REPOSITORY",
      "date_type": "published",
      "institution": "Universitas Muhammadiyah Prof. DR. Hamka",
      "status_changed": "2026-09-16 09:23:19",
      "eprint_status": "archive"
    }