eprintid: 56426
rev_number: 8
eprint_status: archive
userid: 2314
dir: disk0/00/05/64/26
datestamp: 2026-09-16 09:23:24
lastmod: 2026-09-16 09:23:24
status_changed: 2026-09-16 09:23:24
type: thesis
metadata_visibility: show
creators_name: RENASYA FADHILLA UTAMI, RENASYA
title: SKRIPSI-2210015034-RENASYA FADHILLA UTAMI-REPOSITORY
ispublished: pub
subjects: R
subjects: Skripsi
divisions: 11201
abstract: Kanker payudara merupakan salah satu jenis kanker yang paling banyak terjadi
terutama pada wanita. Pengobatan terkait kanker yang efektif dan aman masih terus
dikembangkan, salah satunya dengan bahan alami. Rubus fraxinifolius merupakan salah
satu tanaman yang berpotensi sebagai tanaman obat. Penelitian ini bertujuan untuk
mengetahui pengaruh pemberian ekstrak diklorometan ranting tanaman R. fraxinifolius
terhadap viabilitas sel kanker payudara lini sel MCF-7 secara in vitro. Hasil analisis GCMS
menunjukkan bahwa ekstrak diklorometan ranting R. fraxinifolius mengandung
beberapa senyawa metabolit sekunder seperti asam lemak, fenolik, flavin, dan pyranone,
Sel MCF-7 dikultur dan diberi perlakuan ekstrak dengan konsentrasi 5000 ppm, 1250 ppm,
625 ppm, dan 312,5 ppm. Setelah sel MCF-7 diberi perlakuan dan diinkubasi selama 24
jam, selanjutnya melakukan analisis uji sitotoksik dengan metode MTT assay. Nilai
absorbansi diukur menggunakan ELISA reader dan dianalisis untuk membuat kurva dosisrespon
serta menentukan nilai IC50. Hasil penelitian menunjukkan ekstrak diklorometan
ranting R. fraxinifolius memiliki nilai IC50 >5000 μg/mL. Meskipun demikian, ekstrak ini
menunjukkan pengaruh terhadap viabilitas sel MCF-7 yang ditandai dengan peningkatan
presentase inhibisi seiring dengan peningkatan konsentrasi. Sehingga ekstrak diklorometan
ranting R. fraxinifolius memiliki potensi untuk mempengaruhi pertumbuhan sel MCF-7
meskipun dengan aktivitas sitotoksik yang tergolong rendah.
Kata kunci: Rubus fraxinifolius, Kanker payudara, MCF-7, Antikanker
date: 2026
date_type: published
full_text_status: restricted
institution: Universitas Muhammadiyah Prof. DR. Hamka
department: PROGRAM STUDI PENDIDIKAN DOKTER
thesis_type: bachelor
thesis_name: bphil
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citation:   RENASYA FADHILLA UTAMI, RENASYA  (2026) SKRIPSI-2210015034-RENASYA FADHILLA UTAMI-REPOSITORY.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. Hamka.   
document_url: http://repository.uhamka.ac.id/id/eprint/56426/1/SKRIPSI-2210015034-RENASYA%20FADHILLA%20UTAMI-REPOSITORY.pdf