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      "rev_number": 8,
      "thesis_type": "bachelor",
      "ispublished": "pub",
      "abstract": "Kanker payudara merupakan salah satu jenis kanker yang paling banyak terjadi\r\nterutama pada wanita. Pengobatan terkait kanker yang efektif dan aman masih terus\r\ndikembangkan, salah satunya dengan bahan alami. Rubus fraxinifolius merupakan salah\r\nsatu tanaman yang berpotensi sebagai tanaman obat. Penelitian ini bertujuan untuk\r\nmengetahui pengaruh pemberian ekstrak diklorometan ranting tanaman R. fraxinifolius\r\nterhadap viabilitas sel kanker payudara lini sel MCF-7 secara in vitro. Hasil analisis GCMS\r\nmenunjukkan bahwa ekstrak diklorometan ranting R. fraxinifolius mengandung\r\nbeberapa senyawa metabolit sekunder seperti asam lemak, fenolik, flavin, dan pyranone,\r\nSel MCF-7 dikultur dan diberi perlakuan ekstrak dengan konsentrasi 5000 ppm, 1250 ppm,\r\n625 ppm, dan 312,5 ppm. Setelah sel MCF-7 diberi perlakuan dan diinkubasi selama 24\r\njam, selanjutnya melakukan analisis uji sitotoksik dengan metode MTT assay. Nilai\r\nabsorbansi diukur menggunakan ELISA reader dan dianalisis untuk membuat kurva dosisrespon\r\nserta menentukan nilai IC50. Hasil penelitian menunjukkan ekstrak diklorometan\r\nranting R. fraxinifolius memiliki nilai IC50 >5000 \u03bcg/mL. Meskipun demikian, ekstrak ini\r\nmenunjukkan pengaruh terhadap viabilitas sel MCF-7 yang ditandai dengan peningkatan\r\npresentase inhibisi seiring dengan peningkatan konsentrasi. Sehingga ekstrak diklorometan\r\nranting R. fraxinifolius memiliki potensi untuk mempengaruhi pertumbuhan sel MCF-7\r\nmeskipun dengan aktivitas sitotoksik yang tergolong rendah.\r\nKata kunci: Rubus fraxinifolius, Kanker payudara, MCF-7, Antikanker",
      "divisions": [
        11201
      ],
      "datestamp": "2026-09-16 09:23:24",
      "title": "SKRIPSI-2210015034-RENASYA FADHILLA UTAMI-REPOSITORY",
      "date_type": "published",
      "institution": "Universitas Muhammadiyah Prof. DR. Hamka",
      "status_changed": "2026-09-16 09:23:24",
      "eprint_status": "archive"
    }