<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
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<http://repository.uhamka.ac.id/id/eprint/56382> <http://purl.org/dc/terms/title> "SKRIPSI-2210015031-FATIH ABDURRAHMAN A-REPOSITORY"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://repository.uhamka.ac.id/id/eprint/56382> <http://purl.org/ontology/bibo/abstract> "Eksplorasi agen sitotoksik bahan alam diperlukan untuk mengatasi efek samping dari terapi\r\nkonvensional yang sudah ada pada kanker payudara subtipe Luminal A. Penelitian in vitro\r\nini bertujuan mengevaluasi efek ekstrak metanol daun Mangifera sumbawaensis terhadap\r\nviabilitas dan morfologi sel kanker payudara MCF-7. Komponen bioaktif diekstraksi\r\nmelalui maserasi metanol, lalu diidentifikasi menggunakan Gas Chromatography-Mass\r\nSpectrometry (GC-MS). Uji sitotoksik selanjutnya dilakukan via MTT assay pada\r\nkonsentrasi 62,5–1000 ppm dengan inkubasi selama 24 jam. Analisis data menggunakan\r\nOne-Way ANOVA dan regresi linear untuk menentukan nilai IC!\". Hasil GC-MS\r\nmenunjukkan profil metabolit didominasi ester asam lemak dengan Methyl cis-13-\r\noctadecenoate (20,37%) sebagai komponen utama. Secara mikroskopis, paparan ekstrak\r\nmemicu perubahan morfologi berupa sel membulat, pengerutan sitoplasma, dan serpihan\r\napoptosis pada konsentrasi 500 dan 1000 ppm. Walaupun perlakuan ekstrak Mangifera\r\npada konsentrasi 1000 ppm mampu menurunkan viabilitas sel hingga 47,15%, tren\r\npenurunan tersebut secara statistik tidak menunjukkan perbedaan yang signifikan (p =\r\n0,1044). Perhitungan regresi linear menunjukkan estimasi nilai IC!\" sebesar 947,152 ppm.\r\nHal ini menunjukkan bahwa ekstrak metanol daun Mangifera sumbawaensis memiliki\r\naktivitas sitotoksik yang lemah, namun tetap berpotensi memicu apoptosis pada konsentrasi\r\ntinggi.\r\nKata Kunci: Mangifera sumbawaensis, MCF-7, MTT assay, Sitotoksisitas Lemah."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://repository.uhamka.ac.id/id/eprint/56382> <http://purl.org/dc/terms/date> "2026" .
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<http://repository.uhamka.ac.id/id/subject/R> <http://www.w3.org/2004/02/skos/core#prefLabel> "R Medicine"@en .
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<http://repository.uhamka.ac.id/id/subject/Skripsi> <http://www.w3.org/2004/02/skos/core#prefLabel> "Skripsi" .
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