eprintid: 56380
rev_number: 8
eprint_status: archive
userid: 2314
dir: disk0/00/05/63/80
datestamp: 2026-09-14 08:06:15
lastmod: 2026-09-14 08:06:15
status_changed: 2026-09-14 08:06:15
type: thesis
metadata_visibility: show
creators_name: SHAFAA ALYAA, ALYAA
title: SKRIPSI-2210015030-SHAFAA ALYAA-REPOSITORY
ispublished: pub
subjects: R
subjects: Skripsi
divisions: 11201
abstract: Penyakit infeksi masih menjadi salah satu masalah kesehatan utama dengan kontribusi
besar terhadap beban penyakit global, khususnya infeksi bakteri. Escherichia coli
merupakan patogen penting penyebab berbagai penyakit infeksi dan menunjukkan
kecenderungan peningkatan resistensi terhadap antibiotik, sehingga diperlukan
pengembangan alternatif agen antibakteri. Daun rasamala (Altingia excelsa noronha)
merupakan tanaman obat asli Indonesia yang secara tradisional dimanfaatkan dalam
pengobatan dan diketahui mengandung senyawa bioaktif yang berpotensi sebagai
antibakteri. Penelitian ini bertujuan untuk menguji potensi antibakteri ekstrak metanol daun
rasamala terhadap bakteri Escherichia coli. Penelitian ini merupakan penelitian
eksperimental in vitro menggunakan metode difusi cakram Kirby-Bauer. Analisis
kandungan senyawa dilakukan menggunakan Gas Chromatography-Mass Spectrometry
(GC-MS), hasilnya menunjukkan adanya 62 senyawa yang teridentifikasi, dengan senyawa
dominan yaitu 4-Fluorobenzylamine, N-decyl-N-methyl-. Ekstrak metanol daun rasamala
diuji pada konsentrasi 60%, 70%, 80%, dan 90%, dengan ciprofloxacin sebagai kontrol
positif dan aquades steril sebagai kontrol negatif. Meskipun terdeteksi beberapa senyawa
yang dilaporkan memiliki potensi antibakteri, seluruh konsentrasi ekstrak tidak
menghasilkan zona hambat terhadap pertumbuhan E. coli, sedangkan kontrol positif
menghasilkan rata-rata diameter zona hambat sebesar 35.3 mm. Berdasarkan hasil tersebut,
dapat disimpulkan bahwa ekstrak metanol daun rasamala belum menunjukkan potensi
antibakteri terhadap E. coli pada kondisi pengujian yang digunakan.
Kata Kunci: Daun rasamala, Altinga excelsa, Escherichia coli, antibakteri, difusi cakram,
GC-MS.
date: 2026
date_type: published
full_text_status: restricted
institution: Universitas Muhammadiyah Prof. DR. Hamka
department: PROGRAM STUDI PENDIDIKAN DOKTER
thesis_type: bachelor
thesis_name: bphil
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citation:   SHAFAA ALYAA, ALYAA  (2026) SKRIPSI-2210015030-SHAFAA ALYAA-REPOSITORY.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. Hamka.   
document_url: http://repository.uhamka.ac.id/id/eprint/56380/1/SKRIPSI-2210015030-SHAFAA%20ALYAA-REPOSITORY.pdf