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      "referencetext": "Abo, T., Deguchi, Y., Yuki, T., Takahashi, Y., Miyazawa, M., & Sakaguchi, H.\r\n(2023). Evaluation of MTT reducers and strongly colored substances in the\r\nShort Time Exposure test method for assessing eye irritation potential. The\r\nJournal of Toxicological Sciences, 48(6), 363374. https://doi.org/10.2131/jts.\r\n48.363\r\nAdisti, J. P., Suwirmen, S., & Idris, M. (2023). The Effect of Centella (Centella\r\nasiatica (L.) Urb.) Extract with Several Types of Solvents as a Biostimulant on\r\nthe Growth of Pagoda Mustard (Brassica rapa var. narinosa L.). Jurnal Biologi\r\nUNAND, 11(1), 54\u201361. https://doi.org/10.25077/jbioua.11.1.54-61.2023\r\nAdmoun, C., & Mayrovitz, H. N. (2022). The Etiology of Breast Cancer. Breast\r\nCancer, 21\u201330. https://doi.org/10.36255/Exon-Publications-Breast-Cancer-\r\nEtiology\r\nAli, H. H. (2025). Gas Chromatography: Principles, Medicine and Pharmaceutical,\r\nEnergy, Fuel Applications and Environmental Analysis. SAR Journal of\r\nMedical Biochemistry, 6(04), 94. https://doi.org/10.36346/sarjmb.2025.v06i0\r\n4.005\r\nAmerican Cancer Society. (2021, November 19). Types of Breast Cancer | About\r\nBreast Cancer | American Cancer Society. https://www.cancer.org/cancer/typ\r\nes/breast-cancer/about/types-of-breast-cancer.html\r\nAnderson, D. H. (2021). Luminal A Breast Cancer Resistance Mechanisms and\r\nEmerging Treatments. In Biological Mechanisms and the Advancing\r\nApproaches to Overcoming Cancer Drug Resistance (Vol. 12, pp. 1\u201322).\r\nElsevier. https://doi.org/10.1016/B978-0-12-821310-0.00010-3\r\nBudiarto, A., Raharjo, D., & Rahmatillah, A. (2025). Pengaruh Metode Ekstraksi\r\nMaserasi dan Infudasi terhadap Kadar Flavonoid Total serta Aktivitas\r\nAntioksidan Daun Kunyit (Curcuma Longa L.). Jurnal Kesehatan Amanah,\r\n9(2), 196\u2013206. https://doi.org/10.57214/jka.v9i2.943\r\nAnywar, G. U., Kakudidi, E., Oryem-Origa, H., Schubert, A., & Jassoy, C. (2022).\r\nCytotoxicity of Medicinal Plant Species Used by Traditional Healers in\r\nTreating People Suffering From HIV/AIDS in Uganda. Frontiers in\r\nToxicology, 4. https://doi.org/10.3389/ftox.2022.832780\r\nArya, G. C., Sarkar, S., Manasherova, E., Aharoni, A., & Cohen, H. (2021). The\r\nPlant Cuticle: An Ancient Guardian Barrier Set Against Long-Standing Rivals.\r\nFrontiers in Plant Science, 12. https://doi.org/10.3389/fpls.2021.663165\r\nAshariati, A., Putra, M., & Yudho, U. (2019). Kanker Payudara.\r\nAsman, S. (2023). Extraction of Phytochemical from Murraya Koenigii (L.) Spreng\r\nLeaves using Maceration Method. Scientific Research Journal, 20(2), 147\u2013\r\n160. https://doi.org/10.24191/srj.v20i2.23459\r\nAzad, A. K., Dayoob, M., & Zohera, F. T. (2024). Anticancer Activity of Flavonoids\r\n(pp. 1\u201321). https://doi.org/10.4018/979-8-3693-1646-7.ch001\r\nBabacan, \u00dc., Kaba, A., Akcakale, F., Cengiz, M. F., & Akinci, E. (2022). Optimiz\r\nation of some Parametric Values of MTT for the Determination of Human\r\nMelanoma (SK-Mel-30) Cell Viability. International Journal of Life Sciences\r\nand Biotechnology, 5(1), 9\u201320. https://doi.org/10.38001/ijlsb.991615\r\nBehera, P. C., karmakar, V., Ghosh, A., Dey, S., Rangra, N. K., & Bag, B. (2022).\r\nAnti-cancer Potential of Substituted \u2018Amino-alkyl-rhodamine\u2019 Derivatives Against MCF 7 Human Breast Cancer Cell Line. https://doi.org/10.21203/rs.\r\n3.rs-1797620/v1\r\nBonsou, I. N., Mbaveng, A. T., Nguenang, G. S., Chi, G. F., Kuete, V., & Efferth,\r\nT. (2022). Cytotoxicity, Acute and Sub-chronic Toxicities of the Fruit Extract\r\nof Tetrapleura tetraptera (Schumm. & Thonn.) Taub. (Fabaceae). BMC\r\nComplementary Medicine and Therapies, 22(1), 178. https://doi.org/10.1186/\r\ns12906-022-03659-1\r\nBrown, J. S., Amend, S. R., Austin, R. H., Gatenby, R. A., Hammarlund, E. U., &\r\nPienta, K. J. (2023). Updating the Definition of Cancer. Molecular Cancer\r\nResearch, 21(11), 1142\u20131147. https://doi.org/10.1158/1541-7786.MCR-23-\r\n0411\r\nChaban, V. V. (2025). Solubility Properties of Methanol in Organic Solvents. In\r\nComprehensive Methanol Science (pp. 3753). Elsevier. https://doi.org/10.101\r\n6/B978-0-443-15740-0.00004-5\r\nChen, B., Li, Y., Li, W., Ye, S., Zhu, L., & Ding, Y. (2024). Antitumor Activity and\r\nMechanism of Terpenoids in Seaweeds Based on Literature Review and\r\nNetwork Pharmacology. Advanced Biology, 8(3). https://doi.org/10.1002/adb\r\ni.202300541\r\nChhipa, M. A., Sanayhie, S. A., & Sabatinos, S. A. (2025). Assessing Drug\r\nSensitivity in Fission Yeast Using Half-Maximal Inhibitory Concentration\r\n(IC50) Assays (pp. 241\u2013253). https://doi.org/10.1007/978-1-0716-4168-2_17\r\nCosentino, M., Luini, A., Legnaro, M., Rasini, E., Albizzati, M., Ferrari, M., &\r\nMarino, F. (2021). Cell Storage-02-Freezing and Thawing Protocol for\r\nSuspension Cell Lines v1. https://doi.org/10.17504/protocols.io.bvwxn7fn\r\nDolgikh, M. D., & Zamorina, S. A. (2024). The MCF-7 cell line: Characteristics\r\nand Interaction with Nanomaterials of Different Structures. \u0412\u0435\u0441\u0442\u043d\u0438\u043a\r\n\u041f\u0435\u0440\u043c\u0441\u043a\u043e\u0433\u043e \u0423\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0430. \u0421\u0435\u0440\u0438\u044f \u00ab\u0411\u0438\u043e\u043b\u043e\u0433\u0438\u044f\u00bb=Bulletin of Perm University.\r\nBiology, (2), 231\u2013247. https://doi.org/10.17072/1994-9952-2024-2-231-247\r\nEfek Samping Terapi Radiasi - NCI. (2025, May 15). https://www.cancer.gov/abou\r\nt-cancer/treatment/types/radiation-therapy/side-effects\r\nEl Feky, S., Megahed, M., Abd El Moneim, N., Zaher, E., Khamis, S., & Ali, L.\r\n(2021). Cytotoxic, Chemosensitizing and Radiosensitizing Effects of\r\nCurcumin Based on Thioredoxin System Inhibition in Breast Cancer Cells: 2D\r\nvs. 3D Cell Culture System. Experimental and Therapeutic Medicine, 21(5),\r\n506. https://doi.org/10.3892/etm.2021.9937\r\nEl-Tantawy, H., Hassan, A., & Taha, H. (2022). Anticancer Mechanism of the Nonpolar\r\nExtract from Echium angustifolium Mill. Aerial Parts in Relation to Its\r\nChemical Content. Egyptian Journal of Chemistry, 0(0), 00. https://doi.org/1\r\n0.21608/ejchem.2022.130795.5757\r\nEmerce, E., & Taban Ak\u00e7a, K. (2023). Cytotoxic Activity Methods. In Methods for\r\nPreclinical Evaluation of Bioactive Natural Products (pp. 149\u2013176).\r\nBentham Science Publishers. https://doi.org/10.2174/9789815123043123010\r\n007\r\nFerlay, J., Colombet, M., Soerjomataram, I., Parkin, D. M., Pi\u00f1eros, M., Znaor, A.,\r\n& Bray, F. (2022). Cancer statistics for the year 2020: An overview.\r\nInternational Journal of Cancer, 149(4), 778789. https://doi.org/10.1002/ijc.\r\n33588\r\nGambacurta, A., Tullio, V., Savini, I., Catani, M. V., & Gasperi, V. (2025). In Vitro\r\nCell-Based MTT and Crystal Violet Assays for Drug Toxicity Screening (pp.\r\n293\u2013301). https://doi.org/10.1007/978-1-0716-4003-6_14\r\nGao, X., Guo, Y., Chen, K., Wang, H., & Xie, W. (2024). Study on the Chemical\r\nConstituents, Pharmacological Activities, and Clinical Application of Taxus.\r\nThe American Journal of Chinese Medicine, 52(05), 1329 1357. https://doi.o\r\nrg/10.1142/S0192415X24500538\r\nGarg, P., Pareek, S., Kulkarni, P., Horne, D., Salgia, R., & Singhal, S. S. (2024).\r\nNext-Generation Immunotherapy: Advancing Clinical Applications in Cancer\r\nTreatment. Journal of Clinical Medicine, 13(21), 6537. https://doi.org/10.339\r\n0/jcm13216537\r\nGhasemi, M., Turnbull, T., Sebastian, S., & Kempson, I. (2021a). The MTT Assay:\r\nUtility, Limitations, Pitfalls, and Interpretation in Bulk and Single Cell Analy\r\nsis. International Journal of Molecular Sciences, 22(23), 12827. https://doi.o\r\nrg/10.3390/ijms222312827\r\nHernandes, E. P., Bini, R. D., Endo, K. M., de Oliveira Junior, V. A., de Almeida, I.\r\nV., Dias, G. S., dos Santos, I. A., de Oliveira, P. N., Vicentini, V. E. P., & Cotica,\r\nL. F. (2022). Doxorubicin-Loaded Magnetic Nanoparticles: Enhancement of\r\nDoxorubicin\u2019s Effect on Breast Cancer Cells (MCF-7). Magnetochemistry,\r\n8(10), 114. https://doi.org/10.3390/magnetochemistry8100114\r\nHero, K., & Syifa. (2021). Faktor Risiko Kanker Payudara. 03(01), 3\u20138.\r\nhttp://jurnalmedikahutama.com\r\nHidayat, Asep., Rachmat, H. Hendalastuti., & Subiakto, Atok. (2014). Taxus suma\r\ntrana : Mutiara Terpendam dari Zamrud Sumatra. Forda Press.\r\nIndriani, F., Surya, M. I., Kurniawan, V., Kuswanda, W., Haidir, H., & Fahrisa, A.\r\nS. (2025). The Chloroplast Genome of Taxus sumatrana, an Endangered Med\r\nicinal Tree from Indonesia. BMC Research Notes, 18(1), 435. https://doi.org/\r\n10.1186/s13104-025-07450-6\r\nIPNI. (2024). Taxus Sumatrana (Miq.) de Laub. Kalikasan: Philippine Journal of\r\nBiology. Quezon City. https://plantamor.com/species/profile/taxus/sumatrana\r\n#gsc.tab=0\r\nJeong, S. H., Kim, H. H., Ha, S. E., Park, M. Y., Bhosale, P. B., Abusaliya, A., Park,\r\nK. Il, Heo, J. D., Kim, H. W., & Kim, G. S. (2022). Flavones: Six Selected\r\nFlavones and Their Related Signaling Pathways That Induce Apoptosis in\r\nCancer. International Journal of Molecular Sciences, 23(18), 10965. https://d\r\noi.org/10.3390/ijms231810965\r\nParasian, J., Susilowati, Y., Nuryanti, N., Septimar, Z., & Haeriyah, S., (2023).\r\nHubungan Efek Samping Kemoterapi dengan Kualitas Hidup Pasien Kanker\r\nPayudara di Rumah Sakit Kanker Dharmais Provinsi DKI Jakarta Tahun 2023.\r\nTermometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran, 2(1), 115\u2013126.\r\nhttps://doi.org/10.55606/termometer.v2i1.2808\r\nKamran, S., Sinniah, A., Abdulghani, M. A. M., & Alshawsh, M. A. (2022).\r\nTherapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping\r\nReview. Cancers, 14(5), 1100. https://doi.org/10.3390/cancers14051100\r\nKEMENKES. (2022, February 2). Kanker Payudara Paling Banyak di Indonesia,\r\nKemenkes Targetkan Pemerataan Layanan Kesehatan. https://kemkes.go.id/i\r\nd/kanker-payudaya-paling-banyak-di-indonesia-kemenkes-targetkanpemerataan-\r\nlayanan-kesehatan\r\nKonopleva, M., Zhang, W., Shi, Y.-X., McQueen, T., Tsao, T., Abdelrahim, M.,\r\nMunsell, M. F., Johansen, M., Yu, D., Madden, T., Safe, S. H., Hung, M.-C.,\r\n& Andreeff, M. (2006). Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-\r\ndien-28-oic Acid Induces Growth Arrest in HER2-Overexpressing Breast\r\nCancer Cells. Molecular Cancer Therapeutics, 5(2), 317328. https://doi.org/1\r\n0.1158/1535-7163.MCT-05-0350\r\nKumar, V., Abbas, A., & Aster, J. (2020). Robbins and Cotran Pathologic Basis of\r\nDiseases (10th ed.).\r\nKurniawan, R., Sukrasno, S., Ashari, A., & Suhartati, T. (2025). Diving into\r\npaclitaxel: Isolation and Screening Content from Taxus sumatrana at Singgal\r\nang Conservation Center, West Sumatra. Natural Product Research, 39(10),\r\n2758\u20132762. https://doi.org/10.1080/14786419.2024.2312540\r\nLani, R., AbuBakar, S., & Hassandarvish, pouya. (2023). Adaptation of Human\r\nHepatocellular Carcinoma (HUH7) Cells Maintained in High-\r\nGlucose Dulbecco\u2019s Modified Eagle Medium (DMEM) to Roswell Paek Mem\r\norial Institute (RPMI)1640 MEDIUM v1. https://doi.org/10.17504/protocols.i\r\no.n92ldmm97l5b/v1\r\nLe\u00f3n-Mej\u00eda, G., Miranda Guevara, A., Fiorillo Moreno, O., & Uribe Cruz, C.\r\n(2021). Cytotoxicity as a Fundamental Response to Xenobiotics. In Cytotoxic\r\nity \u2013 New Insights into Toxic Assessment. IntechOpen. https://doi.org/10.5772\r\n/intechopen.96239\r\nLima, J. B. de, Silva, I. C. R. da, & Reis de Oliveira, J. (2024). Molecular subtypes\r\nof breast cancer: clinicopathological characteristics and prognosis. Concilium,\r\n24(10), 581\u2013598. https://doi.org/10.53660/CLM-3881-24P73\r\nMachado, F. P., Diniz-dos-Santos, A. C., de Queiroz, L. N., Fernandes, C. P., Rocha,\r\nL., & Robbs, B. K. (2026). Cell death by apoptosis induced by Ocotea indecora\r\n(Schott) Mez essential oil in different cancer cell lines. Natural Product\r\nResearch, 40(10), 29302936. https://doi.org/10.1080/14786419.2024.244349\r\n2\r\nMahdania Harun, H., Jannah, N., Idawati, I., & Fikar Ahmad, Z. (2023). Evaluasi\r\nPengobatan Radioterapi Pada Pasien Kanker. Journal Syifa Sciences and\r\nClinical Research, 4(3). https://doi.org/10.37311/jsscr.v4i3.15794\r\nMalakpour-Permlid, A., & Oredsson, S. (2022). Two-dimensional cell culturing on\r\nglass and plastic: the past, the present, and the future. In 3D Lung Models for\r\nRegenerating Lung Tissue (pp. 2135). Elsevier. https://doi.org/10.1016/B978-\r\n0-323-90871-9.00008-5\r\nMasitah, M., Pribadi, T., Pratama, M. I., Harrist, R. F., Sari, P. A., Dianita, F., &\r\nSetiawan, V. K. (2023). Analisis Kandungan Metabolik Sekunder pada Daun\r\nKenikir (Cosmos Caudatus Kunth.) Dengan Pelarut Metanol, Etanol, dan Etil\r\nAsetat. BIOEDUKASI (Jurnal Pendidikan Biologi), 14(2), 266. https://doi.or\r\ng/10.24127/bioedukasi.v14i2.7805\r\nMoon, H., Ospina-Mu\u00f1oz, N., Noe-Kim, V., Yang, Y., Elzey, B. D., Konieczny, S.\r\nF., & Han, B. (2020). Subtype-specific Characterization of Breast Cancer\r\nInvasion Using a Microfluidic Tumor Platform. PLOS ONE, 15(6), e0234012.\r\nhttps://doi.org/10.1371/journal.pone.0234012\r\nNasser, R. M. (2025). Isomerism in Organic Compounds. In Principles,\r\nApplications, and Advances of Organic Reaction Mechanisms (pp. 247\u2013272).\r\nIGI Global. https://doi.org/10.4018/979-8-3693-6473-4.ch007\r\nOrrantia-Borunda, E., Anchondo-Nu\u00f1ez, P., Acu\u00f1a-Aguilar, L. E., G\u00f3mez-Valles,\r\nF. O., & Ram\u00edrez-Valdespino, C. A. (2022). Subtypes of Breast Cancer. In\r\nBreast Cancer (pp. 31\u201342). Exon Publications. https://doi.org/10.36255/exonpublications-\r\nbreast-cancer-subtypes\r\nPaddillaya, N., Ingale, K., Gaikwad, C., Saini, D. K., Pullarkat, P., Kondaiah, P.,\r\nMenon, G. I., & Gundiah, N. (2022). Cell adhesion strength and tractions are\r\nmechano-diagnostic features of cellular invasiveness. Soft Matter, 18(23),\r\n4378\u20134388. https://doi.org/10.1039/D2SM00015F\r\nPanayotova, E., & Atanassova, A. (2022). Necroptosis\u2014an Inflammatory Mode of\r\nCell Death. Varna Medical Forum, 11(1), 47. https://doi.org/10.14748/vmf.v\r\n0i0.8270\r\nPanda, V. K., Mishra, B., Mahapatra, S., Swain, B., Malhotra, D., Saha, S., Khanra,\r\nS., Mishra, P., Majhi, S., Kumari, K., Nath, A. N., Saha, S., Jena, S., & Kundu,\r\nG. C. (2025). Molecular Insights on Signaling Cascades in Breast Cancer: A\r\nComprehensive Review. Cancers, 17(2), 234. https://doi.org/10.3390/cancers\r\n17020234\r\nParwanto, E., & Digambiro, R. (2024). Prinsip Terapi Kanker.\r\nPatel, M. M., & Adrada, B. E. (2024). Hereditary Breast Cancer. Radiologic Clinics\r\nof North America, 62(4), 627\u2013642. https://doi.org/10.1016/j.rcl.2023.12.014\r\nPutri, D. E., Almahdy, A., Hamidi, D., & Wahyuni, F. S. (2023). The Journal of\r\nFood and Medicinal Plants The Potential of Taxus sumatrana as a Candidate\r\nfor Cancer Therapy. The Journal of Food and Medicinal Plants, 4(1), 1\u20137.\r\nhttps://doi.org/10.25077/jfmp.4.1.1-7.2023\r\nPutri, D. E., Almahdy, A., Putra, Y. U., Hamidi, D., & Wahyuni, F. S. (2025).\r\nInvestigation of the Apoptosis Mechanism Induced by Taxus sumatrana\r\nExtract Leaf in Cervical Cancer Cells. International Journal of Applied\r\nPharmaceutics, 17 (Special Issue 1), 2736. https://doi.org/10.22159/ijap.202\r\n5.v17s1.05\r\nPutri Prakarsa, C., Bodhi, W., & Datu, O. S. (2024). Uji Aktivitas Fagositosis\r\nMakrofag Ekstrak Tanaman Gedi (Ablemoschus Manihot L.) Sebagai\r\nImunomodulator. 13, 419\u2013430. https://doi.org/10.35799/pha.13.2024.49698\r\nRadonis, A., & Zekic, M. (2023). Volatile Compounds Identified in Traditional\r\nCroatian Cow\u2019s and Goat\u2019s Cheeses Matured in Lambskin Sack Determined\r\nby GC-MS Analysis. Chemistry Journal of Moldova, 18(1), 61\u201369.\r\nhttps://doi.org/10.19261/cjm.2023.1076\r\nRoma, L. P., & Santos, D. Y. A. C. (2022). A Comprehensive Review of the Chemical\r\nComposition and Epicuticular Wax Morphology of the Cuticle in\r\nSapindales. Brazilian Journal of Botany, 45(1), 514. https://doi.org/10.1007/\r\ns40415-021-00723-x\r\nSalvi, S. A. (2024). Extraction. In A Text Book of Pharmaceutics for I Year Diploma\r\nin Pharmacy (pp. 271305). Thinkplus Pharma Publications. https://doi.org/1\r\n0.69613/sr8s3760\r\nSaputra, I. P. B. A., & Sukanty, N. M. W. (2024). Analisis GC-MS dari Senyawa\r\nBioaktif Ekstrak Etanol Daun Tanaman Sirsak (Annona muricata L.) sebagai\r\nObat Tradisional. Bioscientist : Jurnal Ilmiah Biologi, 12(1), 565. https://doi.\r\norg/10.33394/bioscientist.v12i1.10330\r\nSari, W. K., Periadnadi, P., & Nurmiati, N. (2024). Morphotype Analysis of\r\nEndophytic Fungus Isolated from Taxus sumatrana of Mount Singgalang, West Sumatra Region. Jurnal Biologi Tropis, 24(3), 265272. https://doi.org/10.293\r\n03/jbt.v24i3.7154\r\nShuba, I. M., Lylo, V. V., Karpova, I. S., Glavatskyi, O. Y., & Kornelyuk, O. I.\r\n(2025). Determination of Viability of Primary Glioblastoma Cell Culture\r\nUnder the Influence of Various Concentrations of Endothelial Monocyteactivating\r\nPolypeptide II (EMAP II) Using Trypan Blue Staining. Faktori Eks\r\nperimental\u2019noi Evolucii Organizmiv, 37, 199202. https://doi.org/10.7124/FE\r\nEO.v37.1772\r\nSimon, A., & Robb, K. (2024). Breast Cancer. Cambridge Handbook of\r\nPsychology, Health and Medicine, Second Edition, 577580. https://doi.org/10\r\n.1017/CBO9780511543579.131\r\nSingh, R., & Nitesh Kumar Sain, M. (2023). Etiology of Breast Cancer. Journal of\r\nPharmaceutical Negative Results, 14. https://doi.org/10.47750/pnr.2023.14.0\r\n3.192\r\nSinghal, S., Singh, M., Singh, R. K., Tiwari, V. K., & Bajpai, S. (2021). Molecular\r\nMechanisms Underlying Breast Cancer and Role of Plant Products in Targeted\r\nTherapy. In Discovery and Development of Anti-Breast Cancer Agents from\r\nNatural Products (pp. 295\u2013351). Elsevier.\r\nSinkala, M., Naran, K., Ramamurthy, D., Mungra, N., Dzobo, K., Martin, D., &\r\nBarth, S. (2024). Machine Learning and Bioinformatic Analyses Link the Cell\r\nSurface Receptor Transcript Levels to the Drug Response of Breast Cancer\r\nCells and Drug Off-target Effects. Plos One, 19(2), e0296511.\r\nhttps://doi.org/10.1371/journal.pone.0296511\r\nStujanna, E., Ningsih, S., Nurusshofa, Z., Putri, N., Yashiro, T., & Sukarya, W.\r\n(2024). Affordable and Simple Protocol for Immunofluorescence Staining of\r\nInsulin Secreting iGL Cell Line 2D and 3D. Research, 2. https://doi.org/10.52\r\n442/omujecm.41.3.24\r\nSuharyani, S., & Danan Jaya, B. P. (2023). Assessment of the Cytotoxic Effects of\r\nDimethyl Sulfoxide (DMSO) on MCF-7 and HeLa Cell Line. Jurnal Media\r\nKesehatan, 16(1), 1\u20138. https://doi.org/10.33088/jmk.v16i1.926\r\nSukumaran, A., K. Sweety, V., Vikas, B., & Joseph, B. (2023). Cytotoxicity and Cell\r\nViability Assessment of Biomaterials. In Cytotoxicity \u2013 Understanding Cellul\r\nar Damage and Response. IntechOpen. https://doi.org/10.5772/intechopen.11\r\n1822\r\nTawari, E. P., & Ere, M. P. (2024). Characterization of a Drug Resistant MCF-7\r\nBreast Cancer Cell Line Developed by Repeated Cycles of 5-Fluorouracil (5-\r\nFU) Therapy. International Journal of Science and Research Archive, 13(2),\r\n500\u2013505. https://doi.org/10.30574/ijsra.2024.13.2.2166\r\nTian, T. (2022). Commentary: A GSH/CB Dual-controlled Self-assembled\r\nNanomedicine for High efficacy Doxorubicin resistant Breast Cancer Therap\r\ny. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.108191\r\n2\r\nTomilova, S. V., Globa, E. B., Demidova, E. V., & Nosov, A. M. (2023). Secondary\r\nMetabolism in Taxus spp. Plant Cell Culture In Vitro. Russian Journal of Plant\r\nPhysiology, 70(3), 23. https://doi.org/10.1134/S102144372270008X\r\nTripathi, K., Srivastava, Y., & Kumar, N. (2025). Trypan blue dye exclusion assay:\r\nPrinciples, protocols, and applications in cell viability assessment. In\r\nBiotechnology Lab Techniques: Culture Media, Microscopy, and Microbial Analysis (pp. 63\u201365). Deep Science Publishing. https://doi.org/10.70593/978-\r\n93-49307-52-0_9\r\nUkiya, M., Sekine, T., Shimizu, N., Akazawa, H., Tanigawa, M., Suzuki, Y., &\r\nNishina, A. (2023). Amino Acid Conjugates of ent-Beyerane-type Diterpenoids\r\nand Oleanane-type Triterpenoids: Synthesis and Evaluation of Cytotoxic\r\nActivities. Journal of Oleo Science, 72(4), ess21138. https://doi.org/10.5650/j\r\nos.ess21138\r\nUlia, R. V., Suryati, S., & Santoni, A. (2023). Cytotoxic Potential of Essential Oil\r\nIsolated from Clibadium Surinamese L Leaves Against T47D Breast and HeLa\r\nCervical Cancer Cells. Molekul, 18(2), 289. https://doi.org/10.20884/1.jm.20\r\n23.18.2.7816\r\nUniyal, P., Akhtar, A., & Rawat, R. (2025). Flavonoid-Based Combination\r\nTherapies and Nano-Formulations: An Emerging Frontier in Breast Cancer\r\nTreatment. Pharmaceuticals, 18(10), 1486. https://doi.org/10.3390/ph181014\r\n86\r\nVudikala, P. (2024). Filtration. In A Text Book of Pharmaceutics for I Year Diploma\r\nin Pharmacy (pp. 213244). Thinkplus Pharma Publications. https://doi.org/10\r\n.69613/75yagk09\r\nWahyuni, F. S., Putri, D. E., Putra, Y. U., & Hamidi, D. (2024). Cytotoxic Activity\r\nof Taxus Sumatrana (Miq.) De Laub. Bark, Leaves, and Shoots on Hela, T47D,\r\nand Mcf-7/Her2 Cell Lines. International Journal of Applied Pharmaceutics,\r\n16(Special Issue 1), 93\u201398. https://doi.org/10.22159/ijap.2024.v16s1.23\r\nWahyuningsih, S., Yunita, I., Yolla Sundari, U., Nurmalasari, E., & Suryandani, H.\r\n(2024). Ekstraksi Bahan Alam (U. Yolla Sundari, Ed.; 2024th ed.). CV. Gita\r\nLentera Redaksi. https://gitalentera.com\r\nWan, A., Zhang, G., Ma, D., Zhang, Y., & Qi, X. (2023). An overview of the\r\nresearch progress of BRCA gene mutations in breast cancer. Biochimica et\r\nBiophysica Acta (BBA) \u2013 Reviews on Cancer, 1878(4), 188907. https://doi.or\r\ng/10.1016/j.bbcan.2023.188907\r\nWhat Is Cancer? - NCI. (2021, October 11). https://www.cancer.gov/aboutcancer/\r\nunderstanding/what-is-cancer\r\nWHO. (2025, August 14). Kanker Payudara. https://www.who.int/news-room/factsheets/\r\ndetail/breast-cancer\r\nXiong, X., Zheng, L. W., Ding, Y., Chen, Y. F., Cai, Y. W., Wang, L. P., Huang, L.,\r\nLiu, C. C., Shao, Z. M., & Yu, K. Da. (2025). Breast cancer: pathogenesis and\r\ntreatments. In Signal Transduction and Targeted Therapy (Vol. 10, Number 1).\r\nSpringer Nature. https://doi.org/10.1038/s41392-024-02108-4\r\nYunus, M., & Ferdiansyah. (2022). Bioaktivitas Senyawa Metabolit Sekunder dari\r\nBatang Cemara Gunung (Taxus Sumatrana) terhadap Sel Kanker HeLa.\r\nhttps://repository.itera.ac.id/depan/submission/SB2208270007\r\nZetira Muchtar, Z., Adisasmita, A. C., & Firli Bramantyo, D. (2025). Gambaran\r\nFaktor Risiko Waktu Terapi Radiasi yang Berkepanjangan pada Pasein kanker\r\nPayudara: Studi Cross-sectional di RSUP Dr. Kariadi Tahun 2023. Jurnal\r\nEpidemiologi Kesehatan Indonesia, 9(2). https://doi.org/10.7454/epidkes.v9i\r\n2.1142\r\nZhang, P., Liu, H., Yu, Y., Peng, S., Zeng, A., & Song, L. (2025). Terpenoids\r\nMediated Cell Apoptotsis in Cervical Cancer: Mechanisms, advances and\r\nprospects. Fitoterapia, 180, 106323.\r\nhttps://doi.org/10.1016/j.fitote.2024.106323",
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