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      "department": "PROGRAM STUDI PENDIDIKAN DOKTER",
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      "referencetext": "Abdallah, E. M., Alhatlani, B. Y., de Paula Menezes, R., & Martins, C. H. G.\r\n(2023). Back to Nature: Medicinal Plants as Promising Sources for\r\nAntibacterial Drugs in the Post-Antibiotic Era. Plants (Basel, Switzerland),\r\n12(17). https://doi.org/10.3390/plants12173077\r\nAhmed Bahram Wlia, & Soma Majedi. (2025). Optimizing hygiene and microbial\r\naspect of paper recycling: a sustainable approach for environmental\r\nconservation. Cellular and Molecular Biology, 71(3), 151\u2013157.\r\nhttps://doi.org/10.14715/cmb/2025.71.3.18\r\nAlbien, A.-L., & Stark, T. D. (2023). (Bio)active Compounds in Daisy Flower\r\n(Bellis perennis). Molecules (Basel, Switzerland), 28(23). https://doi.org/10.33\r\n90/molecules28237716\r\nAl-Saleh, A., Shahid, M., Farid, E., & Bindayna, K. (2022). Trends in methicillinresistant\r\nStaphylococcus aureus in the Gulf Cooperation Council countries:\r\nantibiotic resistance, virulence factors and emerging strains. 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A Mini-Review of Enteroaggregative\r\nEscherichia coli with a Specific Target on the Virulence Factors Controlled by the\r\nAggR Master Regulator. Polish Journal of Microbiology, 72(4), 347\u2013354.\r\nhttps://doi.org/10.33073/pjm-2023-037\r\nJi, Q.-Y., Wang, W., Yan, H., Qu, H., Liu, Y., Qian, Y., & Gu, R. (2023). The Effect\r\nof Different Organic Acids and Their Combination on the Cell Barrier and\r\nBiofilm of Escherichia coli. Foods, 12(16), 3011. https://doi.org/10.3390/foods12163011\r\nJung, B., & Hoilat, G. J. (2025). MacConkey Medium.\r\nKarahan, F. (2020a). Morphology, anatomy, palynology and achene\r\nmicromorphology of Bellis L. (Asteraceae) species from Turkey. Acta Botanica\r\nCroatica, 79(1), 59\u201367. https://doi.org/10.37427/botcro-2020-006\r\nKarahan, F. (2020b). Morphology, anatomy, palynology and achene\r\nmicromorphology of Bellis L. (Asteraceae) species from Turkey. Acta\r\nBotanica Croatica, 79(1), 59\u201367. https://doi.org/10.37427/botcro-2020-006\r\nLasmini, T., Anisha, T., Kesehatan, A., Kesehatan, A., & Paul, J. (n.d.). POLA\r\nKEPEKAAN ANTIBIOTIK ISOLAT BAKTERI ENTEROBACTERIACEAE\r\nKONTAMINAN PADA SIKAT GIGI. Cross- Border, 3, 371\u2013378.\r\nLee, J.-E., Jayakody, J. T. M., Kim, J.-I., Jeong, J.-W., Choi, K.-M., Kim, T.-S.,\r\nSeo, C., Azimi, I., Hyun, J.-M., & Ryu, B.-M. (2024). The Influence of Solvent\r\nChoice on the Extraction of Bioactive Compounds from Asteraceae: A\r\nComparative Review. Foods (Basel, Switzerland), 13(19).\r\nhttps://doi.org/10.3390/foods13193151\r\nLi, J., & Monje-Galvan, V. (2024). Effect of Glycone Diversity on the Interaction of\r\nTriterpenoid Saponins and Lipid Bilayers. ACS Applied Bio Materials, 7(2),\r\n553\u2013563. https://doi.org/10.1021/acsabm.2c00928\r\nLiu, Y., Zhu, J., Liu, Z., Zhi, Y., Mei, C., & Wang, H. (2025). Flavonoids as\r\nPromising Natural Compounds for Combating Bacterial Infections.\r\nInternational Journal of Molecular Sciences, 26(6), 2455.\r\nhttps://doi.org/10.3390/ijms26062455\r\nLobiuc, A., Pav\u0103l, N.-E., Mangalagiu, I. I., Gheorghi\u021b\u0103, R., Teliban, G.-C.,\r\nAm\u0103riuc\u0103i-Mantu, D., & Stoleru, V. (2023). Future Antimicrobials: Natural and\r\nFunctionalized Phenolics. Molecules, 28(3), 1114.\r\nhttps://doi.org/10.3390/molecules28031114\r\nMartak, D., Henriot, C. P., Broussier, M., Couchoud, C., Valot, B., Richard, M.,\r\nCouchot, J., Bornette, G., Hocquet, D., & Bertrand, X. (2020). High Prevalence\r\nof Human-Associated Escherichia coli in Wetlands Located in Eastern France.\r\nFrontiers in Microbiology, 11. https://doi.org/10.3389/fmicb.2020.552566\r\nMichalik, M., Podbielska-Kubera, A., & Dmowska-Koroblewska, A. (2025).\r\nAntibiotic Resistance of Staphylococcus aureus Strains\u2014Searching for New\r\nAntimicrobial Agents\u2014Review. Pharmaceuticals, 18(1), 81.\r\nhttps://doi.org/10.3390/ph18010081\r\nMousa, N., Aiesh, B. M., Jomaa, R., Zouneh, Y., Namrouti, A., Abutaha, A., Al-\r\nJabi, S. W., Sabateen, A., & Zyoud, S. H. (2025). Antibiotic resistance profiles\r\nand risk factors of multidrug-resistant Escherichia coli in a large tertiary care\r\nhospital in a low- and middle-income country. Scientific\r\nReports, 15(1), 26667. https://doi.org/10.1038/s41598-025-12384-x\r\nMueller, M., & Tainter, C. R. (2025a). Escherichia coli Infection. Mueller, M., &\r\nTainter, C. R. (2025b). Escherichia coli Infection. Mueller, M., & Tainter, C. R.\r\n(2025c). Escherichia coli Infection.\r\nMulyawan, B., Widodo, A. D. W., & Endraswari, P. D. (2024). Comparison of\r\ngeneration time between Escherichia coli non- extended spectrum betalactamase\r\n(non-ESBL) and ESBL on ciprofloxacin and tetracycline induction:\r\nExperimental research. Bali Medical Journal, 13(1), 811\u2013815.\r\nhttps://doi.org/10.15562/bmj.v13i1.4890\r\nNandhini, P., Kumar, P., Mickymaray, S., Alothaim, A. S., Somasundaram, J., &\r\nRajan, M. (2022). Recent Developments in Methicillin-Resistant\r\nStaphylococcus aureus (MRSA) Treatment: A Review. Antibiotics, 11(5), 606.\r\nhttps://doi.org/10.3390/antibiotics11050606\r\nNurjanah, G. S., Cahyadi, A. I., & Windria, S. (2020). ESCHERICHIA COLI\r\nRESISTANCE TO VARIOUS KINDS OF ANTIBIOTICS IN ANIMALS\r\nAND HUMANS: A LITERATURE STUDY. Indonesia Medicus Veterinus, 9(6),\r\n970\u2013983. https://doi.org/10.19087/imv.2020.9.6.970\r\nPuji Natalia Kristiani Sitorus, Aina Azzahra, Dimas Ramadhan Lubis, Karen\r\nZefanya Gulo, Puan Adila, & Tri Amanda Siregar. (2024). Keberadaan\r\nEsherichia Coli Pada Berbagai Jenis Air. Algoritma : Jurnal Matematika, Ilmu\r\nPengetahuan Alam, Kebumian Dan Angkasa, 2(5), 32\u201329.\r\nhttps://doi.org/10.62383/algoritma.v2i5.116\r\nRahmah, W. N., Ramdhani, F. H., & Hidayani, A. (2024). Gambaran Hasil Uji\r\nSensitivitas Antibiotik Terhadap Bakteri Escherichia coli dengan Metode DISC\r\ndan Sumuran. Jurnal Surya Medika, 10(2), 344\u2013348. https://doi.org/10.33084/jsm.v10i2.7495\r\nRahmawati, M. D., Suardana, I. W., & Dharmawan, N. S. (2025).\r\nIDENTIFICATION OF STAPHYLOCOCCUS SP. ISOLATES FROM PIG\r\nTONSILS BASED ON MANNITOL SALT AGAR TEST. Buletin Veteriner\r\nUdayana, 366\u2013377. https://doi.org/10.24843/bulvet.2025.v17.i02.p15\r\nRamirez, D. M., & Schweizer, F. (2025). Development of polymyxin- and\r\naminoglycoside-based outer membrane permeabilizers: a review. Frontiers in\r\nMicrobiology, 16. https://doi.org/10.3389/fmicb.2025.1625300\r\nRasquel-Oliveira, F. S., Ribeiro, J. M., Martelossi-Cebinelli, G., Costa, F. B.,\r\nNakazato, G., Casagrande, R., & Verri, W. A. (2025). Staphylococcus aureus in\r\nInflammation and Pain: Update on Pathologic Mechanisms. 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L., Kannan, S., Khovanskaya,\r\nR., Leipe, D., Mcveigh, R., O\u2019Neill, K., Robbertse, B., Sharma, S., Soussov,\r\nV., Sullivan, J. P., Sun, L., Turner, S., & Karsch- Mizrachi, I. (2020). NCBI\r\nTaxonomy: a comprehensive update on curation, resources and tools.\r\nDatabase, 2020. https://doi.org/10.1093/database/baaa062\r\nShijila Rani, A. S., Babu, S., Anbukumaran, A., Veeramani, S., Ambikapathy, V.,\r\nGomathi, S., & Senthilkumar, G. (2021). Prospective Approaches of\r\nPseudonocardia alaniniphila Hydrobionts for Litopenaeus vannamei. In Advances in Probiotics (pp. 327\u2013348). Elsevier. https://doi.org/10.1016/B978-0-12-\r\n822909-5.00021-6\r\nSizar, O., Leslie, S. W., & Unakal, C. G. (2025). Gram-Positive Bacteria. Taylor,\r\nT. A., & Unakal, C. G. (2025). Staphylococcus aureus Infection.\r\nThiago H. (n.d.). Phytochemical Profile and Qualifi cation of Biological Activity of\r\nan Isolated Fraction of Bellis perennis.\r\nTouaitia, R., Mairi, A., Ibrahim, N. A., Basher, N. S., Idres, T., & Touati, A.\r\n(2025a). Staphylococcus aureus: A Review of the Pathogenesis and Virulence\r\nMechanisms.Antibiotics,14(5),470.https://doi.org/10.3390/antibiotics14050470\r\nTouaitia, R., Mairi, A., Ibrahim, N. A., Basher, N. S., Idres, T., & Touati, A. (2025b).\r\nStaphylococcus aureus: A Review of the Pathogenesis and Virulence\r\nMechanisms.Antibiotics,14(5),470.https://doi.org/10.3390/antibiotics14050470\r\nTuon, F. F., Suss, P. H., Telles, J. P., Dantas, L. R., Borges, N. H., & Ribeiro, V. S.T.\r\n(2023). Antimicrobial Treatment of Staphylococcus aureus Biofilms.\r\nAntibiotics, 12(1), 87. https://doi.org/10.3390/antibiotics12010087\r\nWari Rahman, I., Arfani, N., & Veronica Tadoda, J. (2023). Deteksi Bakteri MRSA\r\nMethicillin-Resistant Staphylococcus aureus pada Sampel Darah Pasien\r\nRawat Inap. https://journal.unhas.ac.id/index.php/jai2\r\nWHO. (2025). Global antibiotic resistance surveillance report 2025 WHO Global\r\nAntimicrobial Resistance and Use Surveillance System (GLASS).\r\nWibisono, F. J., SUMIARTO, B., UNTARI, T., Effendi, M. H., PERMATASARI,\r\nD. A., & WITANINGRUM, A. M. (2020). Short Communication: The presence of\r\nextended-spectrum beta-lactamase (ESBL) producing Escherichia coli on layer\r\nchicken farms in Blitar Area, Indonesia.Biodiversitas Journal of Biological\r\nDiversity, 21(6). https://doi.org/10.13057/biodiv/d210638\r\nWorld Health Organization. (2025). Proportion of bloodstream infection due to\r\nmethicillin-resistant Staphylococcus aureus (MRSA) (%).\r\nYahav, D., Shepshelovich, D., & Tau, N. (2021). Cost Analysis of New Antibiotics\r\nto Treat Multidrug-Resistant Bacterial Infections: Mind the Gap. Infectious\r\nDiseases and Therapy, 10(1), 621\u2013630. https://doi.org/10.1007/s40121-021-\r\n00412-y\r\nAgus Rahmadi, (2023). Albien, A.-L., & Stark, T. D. (2023). (Bio)active Compounds in Daisy Flower\r\n(Bellis perennis). Molecules (Basel, Switzerland), 28(23).\r\nhttps://doi.org/10.3390/molecules28237716\r\nBelay, W. Y., Getachew, M., Tegegne, B. A., Teffera, Z. H., Dagne, A., Zeleke,\r\nT. K., Abebe, R. B., Gedif, A. A., Fenta, A., Yirdaw, G., Tilahun, A., &\r\nAschale, Y. (2024). Mechanism of antibacterial resistance, strategies and\r\nnext-generation antimicrobials to contain antimicrobial resistance: a review.\r\nFrontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1444781\r\nKari\u0107, E., Horozi\u0107, E., Pilipovi\u0107, S., Dautovi\u0107, E., Ibi\u0161evi\u0107, M., D\u017eambi\u0107, A.,\r\n\u010celikovi\u0107, S., & Halil\u010devi\u0107, A. (2023). Tyrosinase Inhibition, Antioxidant and\r\nAntibacterial Activity of Commercial Daisy Extract (Bellis perennis). Journal\r\nofPharmaceuticalResearchInternational,35(5),13\u201319.\r\nhttps://doi.org/10.9734/jpri/2023/v35i57325\r\nMueller, M., & Tainter, C. R. (2025). Escherichia coli Infection.\r\nSizar, O., Leslie, S. W., & Unakal, C. G. (2026). Gram-Positive Bacteria.\r\nWhelan, S., Lucey, B., & Finn, K. (2023). Uropathogenic Escherichia coli\r\n(UPEC)-Associated Urinary Tract Infections: The Molecular Basis for\r\nChallenges to Effective Treatment. Microorganisms, 11(9), 2169.\r\nhttps://doi.org/10.3390/microorganisms11092169\r\nYu, H., Liu, X., Zhang, S., Lei, Y., Zou, B., Xie, P., Sun, B., & Zang, M. (2025).\r\nAdvances in antibacterial strategies of organic acids coupled with cold\r\nsterilization methods for controlling bacterial contamination in beef carcasses\r\nand cuts. Critical Reviews in Food Science and Nutrition, 1\u201316.\r\nhttps://doi.org/10.1080/10408398.2025.2534162",
      "institution": "Universitas Muhammadiyah Prof. DR. Hamka",
      "abstract": "Resistensi antibiotik yang terus meningkat mendorong pencarian sumber\r\nantibakteri alternatif dari bahan alam. Bellis parennis (bunga daisy) diketahui\r\nmengandung berbagai senyawa bioaktif yang berpotensi sebagai antibakteri.\r\nPenelitian ini bertujuan untuk mengetahui efektivitas ekstrak Bellis parennis\r\nterhadap pertumbuhan Staphylococcus aureus dan Escherichia coli secara in vitro\r\nserta menentukan konsentrasi yang memberikan aktivitas antibakteri terbaik.\r\nPenelitian ini merupakan true experimental laboratory research dengan rancangan\r\nposttest-only control group design. Ekstrak Bellis parennis diperoleh melalui\r\nmetode maserasi menggunakan etanol 96% dan diuji pada konsentrasi 0,67 g/mL,\r\n1 g/mL dan 3 g/mL. Aktivitas antibakteri dievaluasi menggunakan metode difusi\r\ncakram Kirby\u2013Bauer terhadap Staphylococcus aureus ATCC 25923 dan\r\nEscherichia coli ATCC 25922, dengan ciprofloxacin sebagai kontrol positif dan\r\nDMSO sebagai kontrol negatif. Data dianalisis menggunakan uji Kruskal\u2013Wallis\r\ndan Mann-Whitney. Hasil penelitian menunjukkan bahwa ekstrak Bellis parennis\r\nmemiliki aktivitas antibakteri terhadap kedua baktersi uji. Pada Staphylococcus\r\naureus, zona hambat terbentuk pada seluruh konsentrasi yang diuji, sedangkan pada\r\nEscherichia coli zona hambat hanya terbentuk pada konsentrasi 3 g/mL. Uji\r\nKruskal-Wallis menunjukkan tidak terdapat perbedaan bermakna antar konsentrasi\r\npada Staphylococcus aureus (p=0,060), tetapi terhadap perbedaan bermakna pada\r\nEscherichia coli (p=0,021). Uji Mann-Whitney menunjukkan bermakna antara\r\nStaphylococcus aureus dan Escherichia coli pada seluruh konsentrasi (p<0,05).\r\nDisimpulkan bahwa ekstrak Bellis parennis memiliki aktivitas antibakteri secara in\r\nvitro dan lebih efektif terhadap Staphylococcus aureus dibandingkan Escherichia\r\ncoli.\r\nKata kunci: Bellis parennis, antibakteri, Staphylococcus aureus, Escherichia\r\ncoli, difusi cakram Kirby\u2013Bauer.",
      "ispublished": "pub",
      "thesis_name": "bphil",
      "creators": [
        {
          "name": {
            "honourific": null,
            "lineage": null,
            "given": "ASHILAH",
            "family": "CUT ASHILAH HAURA"
          }
        }
      ],
      "full_text_status": "restricted",
      "title": "SKRIPSI-2210015020-CUT ASHILAH HAURA-REPOSITORY",
      "datestamp": "2026-09-14 07:22:26",
      "rev_number": 8,
      "divisions": [
        11201
      ],
      "eprintid": 56373
    }