eprintid: 56369
rev_number: 8
eprint_status: archive
userid: 2314
dir: disk0/00/05/63/69
datestamp: 2026-09-14 06:36:15
lastmod: 2026-09-14 06:36:15
status_changed: 2026-09-14 06:36:15
type: thesis
metadata_visibility: show
creators_name: NADIA WAFIKA HASNA, NADIA
title: SKRIPSI-2210015015-NADIA WAFIKA HASNA-REPOSITORY
ispublished: pub
subjects: R
subjects: Skripsi
divisions: 11201
abstract: Karsinoma endometrioid merupakan tipe karsinoma endometrium yang paling sering ditemukan dan berhubungan dengan berbagai faktor risiko reproduktif serta hormonal. Status paritas diketahui memiliki peran protektif terhadap kejadian karsinoma endometrium melalui mekanisme dominasi progesteron selama kehamilan. Namun, penelitian mengenai hubungan status paritas dengan karsinoma endometrioid di Indonesia masih terbatas. Penelitian ini bertujuan untuk mengetahui hubungan antara status paritas dengan kejadian karsinoma endometrioid pada pasien wanita di Rumah Sakit An-Nisa Tangerang periode 2021–2026. Penelitian menggunakan desain observasional analitik dengan pendekatan case-control berbasis data rekam medis. Sampel penelitian berjumlah 55 subjek yang terdiri atas 11 kasus karsinoma endometrioid dan 44 kasus polip endometrium sebagai kelompok kontrol dengan teknik total sampling. Analisis data dilakukan secara univariat dan bivariat menggunakan uji Chi-Square. Hasil penelitian menunjukkan bahwa mayoritas subjek termasuk kelompok non-nullipara (80%), obesitas (65,5%), dan berusia kurang dari 50 tahun (83,6%). Analisis hubungan status paritas dengan diagnosis histopatologi menunjukkan nilai p = 0,273 sehingga tidak terdapat hubungan yang bermakna secara statistik antara status paritas dan karsinoma endometrioid. Hubungan antara IMT dan diagnosis histopatologi juga tidak bermakna (p = 0,832). Sebaliknya, usia menunjukkan hubungan yang bermakna dengan kejadian karsinoma endometrioid (p < 0,001), dengan proporsi kasus lebih tinggi pada kelompok usia >50 tahun. Dapat disimpulkan bahwa status paritas tidak memiliki hubungan yang signifikan dengan kejadian karsinoma endometrioid pada populasi penelitian ini. Faktor usia menunjukkan hubungan yang bermakna dengan kejadian karsinoma endometrioid, sedangkan IMT tidak menunjukkan hubungan yang signifikan.
Kata Kunci : status paritas, karsinoma endometrioid, kanker endometrium, usia, indeks massa tubuh, polip endometrium.
date: 2026
date_type: published
full_text_status: restricted
institution: Universitas Muhammadiyah Prof. DR. Hamka
department: PROGRAM STUDI PENDIDIKAN DOKTER
thesis_type: bachelor
thesis_name: bphil
referencetext: Abdul Hafizz, A. M. H., Mohd Mokthar, N., Md Zin, R. R., P. Mongan, N., Mamat @ Yusof, M. N., Kampan, N. C., Chew, K. T., & Shafiee, M. N. (2025). Insulin-like Growth Factor 1 (IGF1) and Its Isoforms: Insights into the Mechanisms of Endometrial Cancer. Cancers, 17(1), 129. https://doi.org/10.3390/cancers17010129
Barry, J. A., Azizia, M. M., & Hardiman, P. J. (2014). Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: A systematic review and meta-analysis. Human Reproduction Update, 20(5), 748–758. https://doi.org/10.1093/humupd/dmu012
Bassette, E., & Ducie, J. A. (2024). Endometrial Cancer in Reproductive-Aged Females: Etiology and Pathogenesis. Biomedicines, 12(4), 886. https://doi.org/10.3390/biomedicines12040886
Berek, J. S., & Berek, D. L. (with Ovid Technologies, Inc). (2021). Berek & Novak’s gynecology essentials (16th edition). Wolters Kluwer, Lippincott Williams & Wilkins.
Blerj, C. T., & Sorenson, R. L. (2025). Uterus (proliferative phase)—Female Reproductive System [Educational Website]. Histology Guide. https://histologyguide.com/slideview/MH-165-uterus/18-slide-1.html?x=48873&y=8100&z=13.579
Bosch, A. A. S. V. D., Pijnenborg, J. M. A., Romano, A., Winkens, B., Putten, L. J. M. V. D., Kruitwagen, R. F. P. M., & Werner, H. M. J. (2023). The impact of adipose tissue distribution on endometrial cancer: A systematic review. Frontiers in Oncology, 13, 1182479. https://doi.org/10.3389/fonc.2023.1182479
Britannica. (2025, November 15). Uterus. Encyclopedia Britannica. https://www.britannica.com/science/uterus
Bukato, K., Kostrzewa, T., Gammazza, A. M., Gorska-Ponikowska, M., & Sawicki, S. (2024). Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers. Cell Communication and Signaling, 22(1), 205. https://doi.org/10.1186/s12964-024-01583-0
Cancer Australia. (2019). Risk factors for endometrial cancer: A review of the evidence. Surry Hills.
Cunningham, F. G., Leveno,K.J., Bloom, S. L., Dashe, J.S., Spong, C.Y., Hoffman, B. L., & Casey, B. M. (Eds.). (2022). Williams obstetrics (26th edition). McGraw Hill Medical.
Dörk, T., Hillemanns, P., Tempfer, C., Breu, J., & Fleisch, M. C. (2020). Genetic Susceptibility to Endometrial Cancer: Risk Factors and Clinical Management. Cancers, 12(9), 2407. https://doi.org/10.3390/cancers12092407
Firmansyah, G. A., Fauziah, D., & Tjokroprawiro, B. A. (2022). AGE AND BODY MASS INDEX IN TYPE I ENDOMETRIAL CANCER GRADE. Majalah Biomorfologi, 32(2), 73– 81. https://doi.org/10.20473/mbiom.v32i2.2022.73-81
Global Cancer Observatory. (2022). https://gco.iarc.who.int/today/
Hacker, N. F., Gambone, J. C., & Hobel, C. J. (2026). Hacker & Moore’s Essentials of Obstetrics and Gynecology (7th Edition). Elsevier.
Hall, J. E., & Hall, M. E. (2021). Guyton and Hall Textbook of Medical Physiology (14th Edition). Elsevier.
Herrington, C.S. (2020). WHO Classification of Tumours: Female Genital Tumours (5th Edition) (5th Edition). International Agency for Research on Cancer.
Hooks, O., Jhumkhawala, V., Sibson, K., Shrontz, A., Krishnan, S. S., & Ahmad, S. (2025). Diabetes, Obesity, and Endometrial Cancer: A Review. Current Oncology, 32(12), 672. https://doi.org/10.3390/curroncol32120672
Jang, S., & Hwang, S. O. (2024). The risk factors for premalignant and malignant endometrial polyps in premenopausal and postmenopausal women and trends over the past decade: A retrospective study in a single center, South Korea. European Journal of Obstetrics & Gynecology and Reproductive Biology, 295, 118–123. https://doi.org/10.1016/j.ejogrb.2024.01.033
Karunaharamoorthy, A., & Mytilinaios, D. (2023, October 30). Uterus. Kenhub. https://www.kenhub.com/en/library/anatomy/the-uterus
Kumar, V., Abbas, A. K., Aster, J. C., Turner, J. R., Perkins, J. A., Robbins, S. L., & Cotran, R. S. (Eds.). (2021). Robbins & Cotran pathologic basis of disease (Tenth edition). Elsevier.
Maček, P., Molinari, N., Sobočan, M., & Knez, J. (2023). What Role do Androgens Play in Endometrial Cancer? Journal of Personalized Medicine, 13(2), 341. https://doi.org/10.3390/jpm13020341
Mahdy, H., Vadakekut, E. S., & Crotzer, D. (2025). Endometrial Cancer. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK525981/
Makker, V., MacKay, H., Ray-Coquard, I., Levine, D. A., Westin, S. N., Aoki, D., & Oaknin, A. (2021). Endometrial cancer. Nature Reviews Disease Primers, 7(1), 88. https://doi.org/10.1038/s41572-021-00324-8
National Cancer Institute. (2025, April 11). Endometrial Cancer Prevention (PDQ®)—NCI [pdqCancerInfoSummary]. (nciglobal,ncienterprise). https://www.cancer.gov/types/uterine/hp/endometrial-prevention-pdq
National Cancer Institute. (2026, February 10). Endometrial Cancer Prevention (PDQ®)—NCI [pdqCancerInfoSummary]. (nciglobal,ncienterprise). https://www.cancer.gov/types/uterine/hp/endometrial-prevention-pdq
Nurusshofa, Z., Stujanna, E. N., & Ujianti, I. (2025). Penilaian Histopatologis Pada Kuretase Perdarahan Uterus Abnormal. Widina Media Utama.
Ordeanu, I.-M., Busuioc, C. J., Văduva, C.-C., Pană, R.-C., Petrescu, A.-M., Văruț, R. M., Stanciu, M., & Popescu, M. (2025). Obesity as a Catalyst for Endometrial Hyperplasia and Cancer Progression: A Narrative Review of Epidemiology, Molecular Pathways, and Prevention. Biomedicines, 13(11), 2612. https://doi.org/10.3390/biomedicines13112612
Ravegnini, G., Gorini, F., Coada, C. A., De Leo, A., de Biase, D., Di Costanzo, S., De Crescenzo, E., Coschina, E., Monesmith, S., Bernante, P., Garelli, S., Balsamo, F., Hrelia, P., De Iaco, P., Angelini, S., & Perrone, A. M. (2024). miRNA levels are associated with body mass index in endometrial cancer and may have implications for therapy. Cancer Science, 115(3), 883–893. https://doi.org/10.1111/cas.15977
Rosner, J., Samardzic, T., & Sarao, M. S. (2025). Physiology, Female Reproduction. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK537132/
Silverthorn, D. U. (2018). Human Physiology: An Integrated Approach (8th Edition). Pearson.
Umi Choviva, F., Sandhika, W., & Mulawardhana, P. (2024). The prognostic role of mitosis index, stage and grade of endometrial cancer in Dr. Soetomo General Academic Hospital Surabaya, Indonesia, in 2018-2020. Majalah Obstetri & Ginekologi, 32(2), 74– 79. https://doi.org/10.20473/mog.V32I22024.74-79
Vieira, M. D. C., Vitagliano, A., Rossette, M. C., Neto, L. C. D. A., Gallo, A., & Sardo, A. D. S. (2022). Endometrial Polyps: Update Overview on Etiology, Diagnosis, Natural History and Treatment. Clinical and Experimental Obstetrics & Gynecology, 49(10), 232.https://doi.org/10.31083/j.ceog4910232
citation:   NADIA WAFIKA HASNA, NADIA  (2026) SKRIPSI-2210015015-NADIA WAFIKA HASNA-REPOSITORY.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. Hamka.   
document_url: http://repository.uhamka.ac.id/id/eprint/56369/1/SKRIPSI-2210015015-NADIA%20WAFIKA%20HASNA-REPOSITORY.pdf