eprintid: 56367 rev_number: 8 eprint_status: archive userid: 2314 dir: disk0/00/05/63/67 datestamp: 2026-09-14 06:36:29 lastmod: 2026-09-14 06:36:29 status_changed: 2026-09-14 06:36:29 type: thesis metadata_visibility: show creators_name: EKA FERIZA, EKA title: SKRIPSI-2210015013-EKA FERIZA-REPOSITORY ispublished: pub subjects: R subjects: Skripsi divisions: 11201 abstract: Konsumsi kopi merupakan kebiasaan yang umum dijumpai pada mahasiswa kedokteran untuk meningkatkan kewaspadaan dan konsentrasi belajar. Kandungan kafein dan asam klorogenat dalam kopi diketahui memiliki efek diuretik serta berpotensi memengaruhi keseimbangan asam-basa tubuh yang dapat tercermin melalui pH urin. Penelitian ini bertujuan untuk mengetahui hubungan antara kebiasaan minum kopi dengan gambaran pH urin pada mahasiswa Fakultas Kedokteran Universitas Muhammadiyah Prof. DR. HAMKA (UHAMKA). Penelitian ini merupakan penelitian analitik observasional dengan pendekatan potong lintang (cross-sectional). Sampel penelitian terdiri dari 157 mahasiswa Fakultas Kedokteran UHAMKA yang memenuhi kriteria inklusi dan eksklusi. Data kebiasaan minum kopi diperoleh melalui kuesioner terstruktur, sedangkan pH urin diukur menggunakan strip tes pH urin. Analisis data dilakukan secara univariat dan bivariat menggunakan uji Chi-Square dengan tingkat kemaknaan p<0,05. Hasil penelitian menunjukkan bahwa sebagian besar responden berjenis kelamin perempuan (77%). Berdasarkan kebiasaan minum kopi, sebanyak 49% responden memiliki tingkat konsumsi rendah, 29% sedang, dan 22% tinggi. Gambaran pH urin menunjukkan 37% responden memiliki urin asam, 34% netral, dan 29% basa. Hasil uji Chi-Square menunjukkan nilai p=0,852 (p>0,05), yang menunjukkan tidak terdapat hubungan yang bermakna antara kebiasaan minum kopi dengan gambaran pH urin pada mahasiswa Fakultas Kedokteran UHAMKA. Disimpulkan bahwa kebiasaan minum kopi tidak berhubungan secara signifikan dengan gambaran pH urin pada mahasiswa Fakultas Kedokteran UHAMKA. Faktor lain seperti pola makan, status hidrasi, dan kondisi metabolisme tubuh diduga memiliki peran yang lebih besar dalam memengaruhi pH urin. Kata kunci: Hidrasi, Kafein, Kopi, Mahasiswa Kedokteran, pH Urin. date: 2026 date_type: published full_text_status: public pages: 86 institution: Universitas Muhammadiyah Prof. DR. Hamka department: PROGRAM STUDI PENDIDIKAN DOKTER thesis_type: bachelor thesis_name: bphil referencetext: Agustini, S., Agustina, S., & Dharmaputera, D. (2022). The determination of quality and sensory profile of Arabica and Robusta coffee originated from Semendo Indonesia. AIP Conference Proceedings, 2638(1), 60002. Al-Dabbagh, E. H. T., & Alnori, M. K. J. (2022). Effect of pepsi beverages on urine pH, crystalluria, and urinary calcium excretion. MMSL, 91(3), 191– 196. Banerjee, P., Ali, Z., Levine, B., Fowler, D. R., & Michelson, E. A. (2014). Fatal caffeine intoxication: A series of eight cases from the medical examiner’s office in Maryland. Forensic Science International, 244, 47 52. https://doi. org/10.1016/j.forsciint.2014.08.006 Barghouthy, Y., Corrales, M., Doizi, S., Somani, B. K., & Traxer, O. (2021). Tea and coffee consumption and pathophysiology related to kidney stone formation: a systematic review. World Journal of Urology, 39(7), 2417– 2426. Belasco, E. J., Gong, E., & Hendricks, A. E. (2020). Urine color as a practical indicator of hydration status in adults: Validity and applications. Journal of Human Nutrition and Dietetics, 33(5), 667–675. https://doi.org/ 10.1111/jh n.12758 Bonati, M., Latini, R., Tognoni, G., Young, J. F., Garattini, S., & Invernizzi, R. (1982). Caffeine disposition after oral doses. Clinical Pharmacology & Therapeutics, 32(1), 98–106. https://doi.org/10.1038/clpt.1982.134 Buckel, L., Kremer, J. I., Stegmüller, S., & Richling, E. (2019). Fast, Sensitive and Robust Determination of Nicotinic Acid (Vitamin B3) Contents in Coffee Beverages Depending on the Degree of Roasting and Brewing Technique. Proceedings, 87(1). Cooper, M., Safran, M., & Eberhardt, M. (2004). Caffeine consumption among adults on benzodiazepine therapy: United States 1988– 1994. Psychological Reports, 95(1), 183–191. https://doi.org/10.2466/pr0.95.1.1 83-191 da Silva, L. A., Pereira, R. A., Túrmina, J. A., Kerppers, I. I., Osiecki, R., Altimari, L. R., & Malfatti, C. R. M. (2014). Sulfonylurea induction of caffeine- enhanced insulin secretion and reduction of glycemic levels in diabetic rats. Pharmaceutical Biology, 52(8), 956–960. https://doi.org/10.3109/138802 09.2013.874462 Dawidowicz, A. L., & Typek, R. (2017). Transformation of chlorogenic acids during the coffee beans roasting process. European Food Research and Technology, 243(3), 379–390. de Paula, J., Farah, A., & Trugo, L. C. (2019). Caffeine metabolism, pharmacokinetics, and interactions. Food and Chemical Toxicology, 129,41366–379. https://doi.org/10.1016/j.fct.2019.04.039 Doepker, C., Franke, K., Myers, E., Goldberger, J., Lieberman, H. R., O’Brien, C., Peck, J., Tenenbein, M., Weaver, C., Wikoff, D., Welsh, B. T., & Urban, J. (2016). Key findings and implications of a recent systematic review of the potential adverse effects of caffeine consumption. Nutrition Reviews, 74(12), 745–762. https://doi.org/10.1093/nutrit/nuw046 Edwards, A. M., & Buono, M. J. (2022). Urine color as an index of hydration status during exercise and daily activity. European Journal of Applied Physiology, 122(1), 1–9. https://doi.org/10.1007/s00421-021-04815-3 Green, P. J., Kirby, R., & Suls, J. (1996). The effects of caffeine on blood pressure and heart rate: a review. Annals of Behavioral Medicine, 18(3), 201–216. Haddad, R. A. (2024). The Caffeine Usage among Medical Students and Their Knowledge of Its Benefits and Side Effects. Al-Iraqia Medical College Journal, 1(1), 45–55. Indonesia, U. (2022). Survei Konsumsi Kafein dan Pola Minum Kopi Mahasiswa di Indonesia. Universitas Indonesia. Jaffe, D., Hewit, J., Pilotte, N., Beck, G., & Karp, M. (2018). Effects of Caffeine on Physical and Cognitive Performance: A Brief Review. Journal of Sports Science and Medicine. Kalschne, D. L., Silva, N. K., Canan, C., Benassi, M. de T., Flores, E. L. M., & Leite, O. D. (2021). Main minerals and organic compounds in commercial roasted and ground coffee: An exploratory data analysis. Química Nova, 44, 70–75. Kenger, E. B., Ozlu, T., Agopyan, A., Ergun, C., Uslu, A., Dinsel, B., Disli, D., & Akdeniz, N. (2023). The effect of caffeine consumption on attention performance in female students at the faculty of health sciences. Nutrition & Food Science, 53(5), 837–848. Lorist, M. M., & Tops, M. (2003). Caffeine, fatigue, and cognition. Brain and Cognition, 53(1), 82–94. https://doi.org/10.1016/S0278-2626(03)00093-0 Low, Y. L., Lim, S. Y., Teo, Y. Y., Koh, W. P., & Yuan, J. M. (2024). Genetic polymorphisms of CYP1A2 (rs762551) and individual variability in caffeine metabolism. Nutrients, 16(3), 412. https://doi.org/10.339 0/nu16030412 Mandel, H. G. (2002). Update on caffeine consumption, disposition and action. Food and Chemical Toxicology, 40(9), 1231–1234. https://doi.org/1 0.1016/ S0278-6915(02)00093-5 Marx, W., Kelly, J. T., Marshall, S., Cutajar, J., & Burns, S. (2016). The effect of caffeine on renal function and hydration status: A systematic review. Journal of Human Nutrition and Dietetics, 29(6), 659–670. https://doi.org/1 0.1111/jhn.12386 McLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016). A review of caffeine’s effects on cognitive, physical and occupational performance. Neuroscience & Biobehavioral Reviews, 71, 294– 312. https:// doi.org/10.1016/j.neubiorev.2016.09.001 Menezes, C. J., Worcester, E. M., Coe, F. L., Asplin, J. R., Bergsland, K. J., & Ko, B. (2019). Mechanisms for falling urine pH with age in stone formers. American Journal of Physiology-Renal Physiology, 317(1), F65– F72. https://doi.org/10.1152/ajprenal.00043.2019 Mrizak, I., Škorić, I., & Čepelak, I. (2011). Pharmacokinetics and bioavailability of caffeine in healthy subjects. Food and Chemical Toxicology, 49(10), 2525– 2531. https://doi.org/10.1016/j.fct.2011.06.034 Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003). Effects of caffeine on human health. Food Additives & Contaminants, 20(1), 1–30. https://doi.org/10.1080/0265203021000007 840 Nehlig, A., Daval, J.-L., & Debry, G. (1992). Caffeine and the central nervous system: Mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Research Reviews, 17(2), 139–170. http s://doi.org/ 10.10 16/0165-0173(92)90012-B Ni, Y., Zhang, F., An, M., Yin, W., & Gao, Y. (2017). Acute effect of coffee consumption on urinary proteome in young healthy individuals. MOJ Proteomics & Bioinformatics, 5(2). Organization, I. C. (2024). Coffee Market Report 2024. ICO. Perez, E. J., & Li, J. (2016). Caffeine’s effect on neurodegenerative diseases. Neural Regeneration Research, 11(4), 564–567. https://doi.org/10.4103 /1673-5374.180742 Puluhulawa, N., & Supu, R. D. (2022). Identification of Calcium Oxalate in Urine Sediment for Consuming Caffeinated Drinks at Pauwo Village in 2021. Journal of Health, Technology and Science (JHTS), 3(4), 20–28. Rahmadi, A. (2019). Kitab pedoman pengobatan Nabi. WahyuQolbu. Reddy, V. S., Shiva, S., Manikantan, S., & Ramakrishna, S. (2024). Pharmacology of caffeine and its effects on the human body. European Journal of Medicinal Chemistry Reports, 10, 100138. https://doi.org/10 .1016/ j.ejmcr2024.100138 Reuter, T., Schneider, F., & Langer, F. (2021). Drug–caffeine interactions mediated by cytochrome P450 1A2 (CYP1A2): Clinical implica tions. European Journal of Clinical Pharmacology, 77(9), 1299– 1312. https://doi.org/10.1 007/s00228-021-03133-9 Roehrs, T., & Roth, T. (2008). Caffeine: Sleep and daytime sleepiness. Sleep Medicine Reviews, 12(2), 153–162. https://doi.org/10.1016/j.s mrv.2007.0 7.004 Romualdo, G. R., Rocha, A. B., Vinken, M., & Cogliati, B. (2019). Coffee consumption and liver diseases: A systematic review. Clinical Nutrition ESPEN, 31, 1–12. https://doi.org/10.1016/j.clnesp.2019.02.006 Roshan, S., Singh, S., & Choudhary, S. (2016). Caffeine and neurodegenerative diseases: Protective role and possible mechanisms. Journal of Alzheimer’s Disease Reports, 2(1), 45–56. Srivastava, N., & Sarkar, D. (2023). Effect of caffeine on systolic blood pressure and heart rate in healthy young adults. Indian Journal of Applied Research, 13(10), 35. Sudhakar, A., Nayan, V. S. V, & Rasheed, M. (2018). Extraction of caffeine from some tea and coffee samples. J Emerg Technol Innov Res, 5(6), 627–647. Tavares, C., & Sakata, R. K. (2012). Caffeine in the treatment of pain. Brazilian Journal of Anesthesiology, 62(3), 387–401. https://doi.org/10.1016/S0034- 7094(12)70139-3 Tazzeo, T., Bates, J. H. T., Janssen, L. J., & Zuo, L. (2012). Caffeine relaxes airway smooth muscle by inhibiting phosphodiesterase and antagonizing adenosine receptors. Pulmonary Pharmacology & Therapeutics, 25(5), 406–412. https://doi.org/10.1016/j.pupt.2012.07.003 Turnbull, D., Rodricks, J. V, Mariano, G. F., & Chowdhury, F. (2017). Caffeine and cardiovascular health. Regulatory Toxicology and Pharmacology, 89, 165–185. https://doi.org/10.1016/j.yrtph.2017.07.025 van Dam, R. M., Hu, F. B., & Willett, W. C. (2020). Coffee, caffeine, and health. New England Journal of Medicine, 383(4), 369–378. https://doi.org/ 10.1056/NEJMra1816604 Wikoff, D., Welsh, B. T., Henderson, R., Brorby, G. P., Britt, J., Myers, E., Goldberger, J., Lieberman, H. R., O’Brien, C., Peck, J., Tenenbein, M., Weaver, C., Harvey, S., Urban, J., & Doepker, C. (2017). Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food and Chemical Toxicology, 109, 585–648. https://doi.org/10.1016/j.fct.2017.04.002 Wojciechowska, P., Mazurkiewicz, J., & Piskorska-Pliszczynska, J. (2014). Influence of roasting degree on caffeine content in coffee beans. Food Chemistry, 159, 366–371. https://doi.org/10.1016/j.foodchem.2014.03.028 Zulli, A., Smith, R. M., Kubatka, P., Sharman, J. E., & Learmont, J. (2016). Caffeine metabolism and the role of cytochrome P450 1A2 (CYP1A2). Nutrients, 8(10), 629. https://doi.org/10.3390/nu8100629 citation: EKA FERIZA, EKA (2026) SKRIPSI-2210015013-EKA FERIZA-REPOSITORY. Bachelor thesis, Universitas Muhammadiyah Prof. DR. Hamka. document_url: http://repository.uhamka.ac.id/id/eprint/56367/1/SKRIPSI-2210015013-EKA%20FERIZA-REPOSITORY.pdf