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      "department": "PROGRAM STUDI PENDIDIKAN DOKTER",
      "date": 2026,
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      "pages": 86,
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      "subjects": [
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        "Skripsi"
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      "thesis_type": "bachelor",
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      "referencetext": "Agustini, S., Agustina, S., & Dharmaputera, D. (2022). The determination of\r\nquality and sensory profile of Arabica and Robusta coffee originated from\r\nSemendo Indonesia. AIP Conference Proceedings, 2638(1), 60002.\r\nAl-Dabbagh, E. H. T., & Alnori, M. K. J. (2022). Effect of pepsi beverages on\r\nurine pH, crystalluria, and urinary calcium excretion. MMSL, 91(3), 191\u2013\r\n196.\r\nBanerjee, P., Ali, Z., Levine, B., Fowler, D. R., & Michelson, E. A. (2014). Fatal\r\ncaffeine intoxication: A series of eight cases from the medical examiner\u2019s\r\noffice in Maryland. Forensic Science International, 244, 47 52. https://doi.\r\norg/10.1016/j.forsciint.2014.08.006\r\nBarghouthy, Y., Corrales, M., Doizi, S., Somani, B. K., & Traxer, O. (2021). Tea\r\nand coffee consumption and pathophysiology related to kidney stone\r\nformation: a systematic review. World Journal of Urology, 39(7), 2417\u2013\r\n2426.\r\nBelasco, E. J., Gong, E., & Hendricks, A. E. (2020). Urine color as a practical\r\nindicator of hydration status in adults: Validity and applications. Journal\r\nof Human Nutrition and Dietetics, 33(5), 667\u2013675. https://doi.org/\r\n10.1111/jh n.12758\r\nBonati, M., Latini, R., Tognoni, G., Young, J. F., Garattini, S., & Invernizzi, R.\r\n(1982). Caffeine disposition after oral doses. Clinical Pharmacology &\r\nTherapeutics, 32(1), 98\u2013106. https://doi.org/10.1038/clpt.1982.134\r\nBuckel, L., Kremer, J. I., Stegm\u00fcller, S., & Richling, E. (2019). Fast, Sensitive\r\nand Robust Determination of Nicotinic Acid (Vitamin B3) Contents in\r\nCoffee Beverages Depending on the Degree of Roasting and Brewing\r\nTechnique. Proceedings, 87(1).\r\nCooper, M., Safran, M., & Eberhardt, M. (2004). Caffeine consumption among\r\nadults on benzodiazepine therapy: United States 1988\u2013\r\n1994. Psychological Reports, 95(1), 183\u2013191.\r\nhttps://doi.org/10.2466/pr0.95.1.1 83-191\r\nda Silva, L. A., Pereira, R. A., T\u00farmina, J. A., Kerppers, I. I., Osiecki, R.,\r\nAltimari,\r\nL. R., & Malfatti, C. R. M. (2014). Sulfonylurea induction of caffeine- enhanced\r\ninsulin secretion and reduction of glycemic levels in diabetic rats.\r\nPharmaceutical Biology, 52(8), 956\u2013960. https://doi.org/10.3109/138802\r\n09.2013.874462\r\nDawidowicz, A. L., & Typek, R. (2017). Transformation of chlorogenic acids\r\nduring the coffee beans roasting process. European Food Research and\r\nTechnology, 243(3), 379\u2013390.\r\nde Paula, J., Farah, A., & Trugo, L. C. (2019). Caffeine metabolism,\r\npharmacokinetics, and interactions. Food and Chemical Toxicology,\r\n129,41366\u2013379. https://doi.org/10.1016/j.fct.2019.04.039\r\nDoepker, C., Franke, K., Myers, E., Goldberger, J., Lieberman, H. R., O\u2019Brien,\r\nC., Peck, J., Tenenbein, M., Weaver, C., Wikoff, D., Welsh, B. T., &\r\nUrban, J. (2016). Key findings and implications of a recent systematic\r\nreview of the potential adverse effects of caffeine consumption. Nutrition\r\nReviews, 74(12), 745\u2013762. https://doi.org/10.1093/nutrit/nuw046\r\nEdwards, A. M., & Buono, M. J. (2022). Urine color as an index of hydration\r\nstatus during exercise and daily activity. European Journal of Applied\r\nPhysiology, 122(1), 1\u20139. https://doi.org/10.1007/s00421-021-04815-3\r\nGreen, P. J., Kirby, R., & Suls, J. (1996). The effects of caffeine on blood\r\npressure and heart rate: a review. Annals of Behavioral Medicine, 18(3),\r\n201\u2013216.\r\nHaddad, R. A. (2024). The Caffeine Usage among Medical Students and Their\r\nKnowledge of Its Benefits and Side Effects. Al-Iraqia Medical College\r\nJournal, 1(1), 45\u201355.\r\nIndonesia, U. (2022). Survei Konsumsi Kafein dan Pola Minum Kopi Mahasiswa\r\ndi Indonesia. Universitas Indonesia.\r\nJaffe, D., Hewit, J., Pilotte, N., Beck, G., & Karp, M. (2018). Effects of Caffeine\r\non Physical and Cognitive Performance: A Brief Review. Journal of\r\nSports Science and Medicine.\r\nKalschne, D. L., Silva, N. K., Canan, C., Benassi, M. de T., Flores, E. L. M., &\r\nLeite, O. D. (2021). Main minerals and organic compounds in commercial\r\nroasted and ground coffee: An exploratory data analysis. Qu\u00edmica Nova,\r\n44, 70\u201375.\r\nKenger, E. B., Ozlu, T., Agopyan, A., Ergun, C., Uslu, A., Dinsel, B., Disli, D., &\r\nAkdeniz, N. (2023). The effect of caffeine consumption on attention\r\nperformance in female students at the faculty of health sciences. Nutrition\r\n& Food Science, 53(5), 837\u2013848.\r\nLorist, M. M., & Tops, M. (2003). Caffeine, fatigue, and cognition. Brain and\r\nCognition, 53(1), 82\u201394. https://doi.org/10.1016/S0278-2626(03)00093-0\r\nLow, Y. L., Lim, S. Y., Teo, Y. Y., Koh, W. P., & Yuan, J. M. (2024). Genetic\r\npolymorphisms of CYP1A2 (rs762551) and individual variability in\r\ncaffeine metabolism. Nutrients, 16(3), 412. https://doi.org/10.339\r\n0/nu16030412\r\nMandel, H. G. (2002). Update on caffeine consumption, disposition and action.\r\nFood and Chemical Toxicology, 40(9), 1231\u20131234. https://doi.org/1\r\n0.1016/ S0278-6915(02)00093-5\r\nMarx, W., Kelly, J. T., Marshall, S., Cutajar, J., & Burns, S. (2016). The effect of\r\ncaffeine on renal function and hydration status: A systematic review.\r\nJournal of Human Nutrition and Dietetics, 29(6), 659\u2013670.\r\nhttps://doi.org/1 0.1111/jhn.12386\r\nMcLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016). A review of\r\ncaffeine\u2019s effects on cognitive, physical and occupational\r\nperformance. Neuroscience & Biobehavioral Reviews, 71, 294\u2013\r\n312. https:// doi.org/10.1016/j.neubiorev.2016.09.001\r\nMenezes, C. J., Worcester, E. M., Coe, F. L., Asplin, J. R., Bergsland, K. J., &\r\nKo, B. (2019). Mechanisms for falling urine pH with age in stone\r\nformers. American Journal of Physiology-Renal Physiology, 317(1), F65\u2013\r\nF72. https://doi.org/10.1152/ajprenal.00043.2019\r\nMrizak, I., \u0160kori\u0107, I., & \u010cepelak, I. (2011). Pharmacokinetics and bioavailability\r\nof caffeine in healthy subjects. Food and Chemical Toxicology, 49(10),\r\n2525\u2013 2531. https://doi.org/10.1016/j.fct.2011.06.034\r\nNawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M.\r\n(2003). Effects of caffeine on human health. Food Additives &\r\nContaminants, 20(1), 1\u201330. https://doi.org/10.1080/0265203021000007\r\n840\r\nNehlig, A., Daval, J.-L., & Debry, G. (1992). Caffeine and the central nervous\r\nsystem: Mechanisms of action, biochemical, metabolic and\r\npsychostimulant effects. Brain Research Reviews, 17(2), 139\u2013170. http\r\ns://doi.org/ 10.10 16/0165-0173(92)90012-B\r\nNi, Y., Zhang, F., An, M., Yin, W., & Gao, Y. (2017). Acute effect of coffee\r\nconsumption on urinary proteome in young healthy individuals. MOJ\r\nProteomics & Bioinformatics, 5(2).\r\nOrganization, I. C. (2024). Coffee Market Report 2024. ICO.\r\nPerez, E. J., & Li, J. (2016). Caffeine\u2019s effect on neurodegenerative diseases.\r\nNeural Regeneration Research, 11(4), 564\u2013567. https://doi.org/10.4103\r\n/1673-5374.180742\r\nPuluhulawa, N., & Supu, R. D. (2022). Identification of Calcium Oxalate in Urine\r\nSediment for Consuming Caffeinated Drinks at Pauwo Village in 2021.\r\nJournal of Health, Technology and Science (JHTS), 3(4), 20\u201328.\r\nRahmadi, A. (2019). Kitab pedoman pengobatan Nabi. WahyuQolbu.\r\nReddy, V. S., Shiva, S., Manikantan, S., & Ramakrishna, S. (2024).\r\nPharmacology of caffeine and its effects on the human body. European\r\nJournal of Medicinal Chemistry Reports, 10, 100138. https://doi.org/10\r\n.1016/ j.ejmcr2024.100138\r\nReuter, T., Schneider, F., & Langer, F. (2021). Drug\u2013caffeine interactions\r\nmediated by cytochrome P450 1A2 (CYP1A2): Clinical implica\r\ntions. European Journal of Clinical Pharmacology, 77(9), 1299\u2013\r\n1312. https://doi.org/10.1 007/s00228-021-03133-9\r\nRoehrs, T., & Roth, T. (2008). Caffeine: Sleep and daytime sleepiness. Sleep\r\nMedicine Reviews, 12(2), 153\u2013162. https://doi.org/10.1016/j.s mrv.2007.0\r\n7.004\r\nRomualdo, G. R., Rocha, A. B., Vinken, M., & Cogliati, B. (2019). Coffee\r\nconsumption and liver diseases: A systematic review. Clinical Nutrition\r\nESPEN, 31, 1\u201312. https://doi.org/10.1016/j.clnesp.2019.02.006\r\nRoshan, S., Singh, S., & Choudhary, S. (2016). Caffeine and neurodegenerative\r\ndiseases: Protective role and possible mechanisms. Journal of Alzheimer\u2019s\r\nDisease Reports, 2(1), 45\u201356.\r\nSrivastava, N., & Sarkar, D. (2023). Effect of caffeine on systolic blood pressure\r\nand heart rate in healthy young adults. Indian Journal of Applied Research,\r\n13(10), 35.\r\nSudhakar, A., Nayan, V. S. V, & Rasheed, M. (2018). Extraction of caffeine from\r\nsome tea and coffee samples. J Emerg Technol Innov Res, 5(6), 627\u2013647.\r\nTavares, C., & Sakata, R. K. (2012). Caffeine in the treatment of pain. Brazilian\r\nJournal of Anesthesiology, 62(3), 387\u2013401. https://doi.org/10.1016/S0034-\r\n7094(12)70139-3\r\nTazzeo, T., Bates, J. H. T., Janssen, L. J., & Zuo, L. (2012). Caffeine relaxes\r\nairway smooth muscle by inhibiting phosphodiesterase and antagonizing\r\nadenosine receptors. Pulmonary Pharmacology & Therapeutics, 25(5),\r\n406\u2013412. https://doi.org/10.1016/j.pupt.2012.07.003\r\nTurnbull, D., Rodricks, J. V, Mariano, G. F., & Chowdhury, F. (2017). Caffeine\r\nand cardiovascular health. Regulatory Toxicology and Pharmacology, 89,\r\n165\u2013185. https://doi.org/10.1016/j.yrtph.2017.07.025\r\nvan Dam, R. M., Hu, F. B., & Willett, W. C. (2020). Coffee, caffeine, and\r\nhealth. New England Journal of Medicine, 383(4), 369\u2013378.\r\nhttps://doi.org/ 10.1056/NEJMra1816604\r\nWikoff, D., Welsh, B. T., Henderson, R., Brorby, G. P., Britt, J., Myers, E.,\r\nGoldberger, J., Lieberman, H. R., O\u2019Brien, C., Peck, J., Tenenbein, M.,\r\nWeaver, C., Harvey, S., Urban, J., & Doepker, C. (2017). Systematic\r\nreview of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food and Chemical\r\nToxicology, 109, 585\u2013648. https://doi.org/10.1016/j.fct.2017.04.002\r\nWojciechowska, P., Mazurkiewicz, J., & Piskorska-Pliszczynska, J. (2014).\r\nInfluence of roasting degree on caffeine content in coffee beans. Food\r\nChemistry, 159, 366\u2013371. https://doi.org/10.1016/j.foodchem.2014.03.028\r\nZulli, A., Smith, R. M., Kubatka, P., Sharman, J. E., & Learmont, J. (2016).\r\nCaffeine metabolism and the role of cytochrome P450 1A2 (CYP1A2).\r\nNutrients, 8(10), 629. https://doi.org/10.3390/nu8100629",
      "institution": "Universitas Muhammadiyah Prof. DR. Hamka",
      "abstract": "Konsumsi kopi merupakan kebiasaan yang umum dijumpai pada mahasiswa kedokteran\r\nuntuk meningkatkan kewaspadaan dan konsentrasi belajar. Kandungan kafein dan asam\r\nklorogenat dalam kopi diketahui memiliki efek diuretik serta berpotensi memengaruhi\r\nkeseimbangan asam-basa tubuh yang dapat tercermin melalui pH urin. Penelitian ini\r\nbertujuan untuk mengetahui hubungan antara kebiasaan minum kopi dengan gambaran\r\npH urin pada mahasiswa Fakultas Kedokteran Universitas Muhammadiyah Prof. DR.\r\nHAMKA (UHAMKA). Penelitian ini merupakan penelitian analitik observasional dengan\r\npendekatan potong lintang (cross-sectional). Sampel penelitian terdiri dari 157 mahasiswa\r\nFakultas Kedokteran UHAMKA yang memenuhi kriteria inklusi dan eksklusi. Data\r\nkebiasaan minum kopi diperoleh melalui kuesioner terstruktur, sedangkan pH urin diukur\r\nmenggunakan strip tes pH urin. Analisis data dilakukan secara univariat dan bivariat\r\nmenggunakan uji Chi-Square dengan tingkat kemaknaan p<0,05. Hasil penelitian\r\nmenunjukkan bahwa sebagian besar responden berjenis kelamin perempuan (77%).\r\nBerdasarkan kebiasaan minum kopi, sebanyak 49% responden memiliki tingkat konsumsi\r\nrendah, 29% sedang, dan 22% tinggi. Gambaran pH urin menunjukkan 37% responden\r\nmemiliki urin asam, 34% netral, dan 29% basa. Hasil uji Chi-Square menunjukkan nilai\r\np=0,852 (p>0,05), yang menunjukkan tidak terdapat hubungan yang bermakna antara\r\nkebiasaan minum kopi dengan gambaran pH urin pada mahasiswa Fakultas Kedokteran\r\nUHAMKA. Disimpulkan bahwa kebiasaan minum kopi tidak berhubungan secara\r\nsignifikan dengan gambaran pH urin pada mahasiswa Fakultas Kedokteran UHAMKA.\r\nFaktor lain seperti pola makan, status hidrasi, dan kondisi metabolisme tubuh diduga\r\nmemiliki peran yang lebih besar dalam memengaruhi pH urin.\r\nKata kunci: Hidrasi, Kafein, Kopi, Mahasiswa Kedokteran, pH Urin.",
      "ispublished": "pub",
      "thesis_name": "bphil",
      "creators": [
        {
          "name": {
            "honourific": null,
            "lineage": null,
            "given": "EKA",
            "family": "EKA FERIZA"
          }
        }
      ],
      "full_text_status": "public",
      "title": "SKRIPSI-2210015013-EKA FERIZA-REPOSITORY",
      "datestamp": "2026-09-14 06:36:29",
      "rev_number": 8,
      "divisions": [
        11201
      ],
      "eprintid": 56367
    }