TY  - JOUR
JF  - Pharmaciana
Y1  - 2018///
A1  - Lestari, Pramulani Mulya
A1  - YATI, KORI
A1  - Savira, Nanda
N2  - As a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is
added with a thickening agent to create transdermal dosage form. This study aimed to compare the
physical stabilities of ketoconazole microemulsions formed with different thickeners, namely
Carbopol 934 and Carbopol 941. The formula used varying concentrations of Carbopol 934 and
Carbopol 941, i.e., 0.15% and 0.25%. The stability was observed during eight-week storage in which
the conditions were controlled by different degrees of temperature, i.e., 40C, 25-300C (room
temperature), and 400C. The stability tests included organoleptic observation, pH, surface tension,
viscosity, particle size, and zeta potential. Based on the Kruskal-Wallis test results, ketoconazole
microemulsion with Carbopol 941 that had been stored in different temperature showed a significant
difference in particle size (significance value< 0.05), but it did not apply to Carbopol 934. The
evaluation revealed that compared to 0.25% of Carbopol 934, microemulsion with 0.15% of Carbopol
934 had a smaller difference between the time intervals. This research concluded that the use of 0.15%
of Carbopol 934 as a thickener in ketoconazole microemulsion had better physical stability compared
to Carbopol 941 due to the influence of temperature and length of storage.
KW  - physical stability
KW  -  ketoconazole microemulsion
KW  -  thickener
KW  -  Carbopol 934
KW  -  and Carbopol
941
ID  - repository551
UR  - http://journal.uad.ac.id/index.php/PHARMACIANA
AV  - public
IS  - 1
PB  - Universitas Ahmad Dahlan
TI  - Comparison of carbopol 934 and 941 as thickeners on ketoconazole
microemulsions based on physical stability
SP  - 119
EP  - 128
SN  - 2088 4559; e-ISSN: 2477 0256
VL  - 8
ER  -