relation: http://repository.uhamka.ac.id/id/eprint/535/
title: FORMULATION AND PHYSICAL STABILITY NITROGLIYCERINE  MICROEMULTION WITH TWEEN 80 AS SURFACTANT
creator: YATI, KORI
creator: Elfiyani, Rahmah
creator: Hadi Kusuma, Galih
subject: Q Science (General)
description: Nitroglycerin is a drug of choice in the treatment of angina pectoris. Commonly used as buccal, sublingual  and injection. Sublingual treatment cause discomfort and sensation burning on its use. In this research used  forms microemulsion transdermal. Transdermal offers a way alternatives for the delivery of nitroglycerin  without passing through the intestines, so it is more convenient and safe for long term use. Microemulsion is  expected to increase the penetration of the drug because contains high concentrations of surfactants. This  research aims to determine the effect of the active agent nitroglycerin into microemulsion system and see its  physical stability and to obtain the best formulation. Used three variations of the concentration of tween 80,  there is 40%, 42.5% and 45%. Stability testing of physical properties during 8 weeks. From the results of  evaluation data showed that Formula 2 is the best formula with the result, among others, as The following pH  of 5.69 ± 0.01, the viscosity of 1480.26 ± 2.83 Cps, Specific Gravity of 1.0723 ± 0.00011 g / mL, Surface  Tension of 38.52 ± 0.037 dyne / cm and particle size of 77.95 nm.  Keywords: Tween 80, Mikroemulsi, Nitroglycerine, Transdermal
date: 2015-06-03
type: Conference or Workshop Item
type: PeerReviewed
format: text
language: en
identifier: http://repository.uhamka.ac.id/id/eprint/535/1/Proceeding_2nd%20nanotechnology%20seminar%20Juni%202015.pdf
identifier:   YATI, KORI dan Elfiyani, Rahmah dan Hadi Kusuma, Galih  (2015) FORMULATION AND PHYSICAL STABILITY NITROGLIYCERINE MICROEMULTION WITH TWEEN 80 AS SURFACTANT.  In: The 2nd International Conference on Pharmaceutical Nanotechnology/Nanomedicine 2015, Jakarta, Indonesia.