eprintid: 5058
rev_number: 31
eprint_status: archive
userid: 1558
dir: disk0/00/00/50/58
datestamp: 2020-12-29 14:57:45
lastmod: 2021-11-28 09:42:40
status_changed: 2021-11-28 09:42:40
type: article
metadata_visibility: show
creators_name: Siska, Siska
creators_id: siska@uhamka.ac.id
creators_orcid: 0000-0003-4830-9261
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_name: Wahyudi, Priyo
contributors_name: Siska, Siska
contributors_name: Ayu Anggorowati, Dian
title: ALPHA-GLUCOSIDASE INHIBITORY ACTIVITY OF ENDOPHYTIC BACTERIA
METABOLITES OF DAUN SALAM (Syzygium polyanthum (Wight) Walp.)
ispublished: pub
subjects: Q1
divisions: 12
abstract: Diabetes mellitus is a metabolic disease associated with abnormally high level of the sugar glucose in the
blood. One of the treatment to lower the level of blood sugar is using the drug which inhibit the activity
of α-glucosidase. Daun salam (Syzygium polyanthum (Wight) Walp.) also known as bay leaves is a medicinal plant
contains active compound which showed α-glucosidase inhibitory activity. As every vascular plant
contains endophytic bacteria, the purpose of this study was to determine the alpha-glucosidase inhibitory
activity of endophytic bacteria’s metabolites of bay leaves. Isolation of endophytic bacteria was conducted
using direct plating method of bay leaves using NA medium. The obtained bacterial isolates then cultivated in a
liquid F4 medium, incubated for 5 days, and harvested by centrifugation to obtain endophyte’s metabolites.
The supernatant was used for enzyme inhibitory assay using p-nitrophenyl-Alpha-D-glucopyranose (p-NPG) as
a substrate. Results showed that the alpha-glucosidase inhibitory activity of the metabolites of 5 endophytic
bacteria isolates was 37.67%; 37.77%; 36.21; 45.81%; and 41.90%. respectively. It can be concluded that the
metabolites of endophytic bacteria of bay leaves have alpha-glucosidase inhibitory activity.
date: 2016-08
date_type: published
publisher: Fakultas Farmasi dan Sains Universitas Muhammadiyah Prof. Dr. Hamka
full_text_status: public
publication: Prosiding Internasional Seminar
refereed: TRUE
issn: 978-602-71959-2-9
citation:   Siska, Siska  (2016) ALPHA-GLUCOSIDASE INHIBITORY ACTIVITY OF ENDOPHYTIC BACTERIA METABOLITES OF DAUN SALAM (Syzygium polyanthum (Wight) Walp.).  Prosiding Internasional Seminar.   ISSN 978-602-71959-2-9     
document_url: http://repository.uhamka.ac.id/id/eprint/5058/1/17.pdf
document_url: http://repository.uhamka.ac.id/id/eprint/5058/3/ALPHA-GLUCOSIDASE%20INHIBITORY%20ACTIVITY%20OF%20ENDOPHYTIC%20BACTERIA%20METABOLITES%20OF%20DAUN%20SALAM%20%28Syzygium%20polyanthum%20%28Wight%29%20Walp.%29.pdf
document_url: http://repository.uhamka.ac.id/id/eprint/5058/19/17.%20PR%20Prosiding%20FFS_Alpha%202016.pdf