<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin"^^ . "To determine and validate of captopril in presence of apigenin by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in rat plasma. The captopril and apigenin were extracted from rat plasma by protein\r\nprecipitation with acetonitrile. Sample containing captopril and apigenin were analyzed by using LC-MS/MS with\r\nC18 column Acquity® (100 mm×21 mm), 1.7 m particles size column at 40 C. The gradient system of mobile\r\nphase composition was a mixture of 0.1% formic acid and acetonitrile (60; 40 v/v), with flow rate 0.3 ml/second.\r\nMass detection was performed on Waters Xevo Triple Quadrupole equipped with an electrospray ionization\r\n(ESI) source in positive ion mode in the multiple reaction monitoring (MRM) modes. Captopril was detected\r\nat m/z 415 > 21616, apigenin was detected at m/z 27113 > 15307 and propranolol an internal standard was\r\ndetected at m/z 260 > 18317. Results: The method was validated according to EMEA guidelines which showed\r\ngood reproducibility and linearity of 0.9992, the LLOQ were 10 ng/ml for captopril. The precision (%CV) value of\r\nWithin-run and between-run analysis is 3.90–10.90% and 3.77–8.13% whereas the accuracy (%diff) of captopril\r\nwas less than 20%. Stability studies revealed that captopril has been stable for 6 hours at room temperature,\r\nthree freeze-thaw cycles, and at least 120 days at −40 C. Conclusion: The developed LC-MS/MS method\r\nis valid to evaluate captopril in present of apigenin in vitro and meet the requirement of linearity, accuracy,\r\nselectivity, precision, matrix effect, and stability according to EMEA 2011"^^ . "2017" . . . . . "23" . "12" . . "American Scientific Publishers"^^ . . . "Advanced Science Letters"^^ . . . "1936661219367317" . . . . . . . . . . . . "Anton"^^ . "Bahtiar"^^ . "Anton Bahtiar"^^ . . "Priyanto"^^ . "Priyanto"^^ . "Priyanto Priyanto"^^ . . "Siska"^^ . "Siska"^^ . "Siska Siska"^^ . . "Suyatna"^^ . "Franciscus D"^^ . "Suyatna Franciscus D"^^ . . "Abdul"^^ . "Mun`im"^^ . "Abdul Mun`im"^^ . . "Siska"^^ . "Siska"^^ . "Siska Siska"^^ . . . . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Text)"^^ . . . . . "10. ASL_2017_OK.pdf"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Text)"^^ . . . . "10. PR ASL 2017.pdf"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Text)"^^ . . . . "ASL_2017_Determination of Captopril in Rat Plasma by LC-MS_MS in Presence of Apigenin.pdf"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "small.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "small.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Text)"^^ . . . . "10. Bukti Korespondensi_ASL_2017.pdf"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "small.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Determination of Captopril in Rat Plasma by\r\nLC-MS/MS in Presence of Apigenin (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #4862 \n\nDetermination of Captopril in Rat Plasma by \nLC-MS/MS in Presence of Apigenin\n\n" . "text/html" . . . "Q Science (General)"@en . .