eprintid: 48479
rev_number: 6
eprint_status: archive
userid: 1193
dir: disk0/00/04/84/79
datestamp: 2025-11-24 08:22:20
lastmod: 2025-11-24 08:22:20
status_changed: 2025-11-24 08:22:20
type: article
metadata_visibility: show
creators_name: Hadi Sunaryo, Hadi
creators_name: Siska, Siska
creators_id: hadisunaryo@uhamka.ac.id
creators_id: siska@uhamka.ac.id
creators_orcid: 0000-0003-4830-9261
corp_creators: UHAMKA
corp_creators: UHAMKA
title: Evaluation of analgesic and anti-inflammatory activities of
ethanolic extract of Cordia sebestena L.
ispublished: pub
subjects: D1
divisions: 48201
abstract: Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study
was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats.
The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory
activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract
(100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The
extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained
support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further
scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and
clinical settings.
full_text_status: public
publication: EUROPEAN PHARMACEUTICAL JOURNAL
refereed: TRUE
citation:   Hadi Sunaryo, Hadi dan Siska, Siska   Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.  EUROPEAN PHARMACEUTICAL JOURNAL.       
document_url: http://repository.uhamka.ac.id/id/eprint/48479/1/European%20Pharmaceutical%20Journal%20Evaluation%20of%20analgesic%20and%20anti-inflammatory%20activities%20of%20ethanolic%20extract%20of%20Cordia%20sebestena%20L..pdf