eprintid: 48467
rev_number: 7
eprint_status: archive
userid: 1193
dir: disk0/00/04/84/67
datestamp: 2025-11-18 08:29:59
lastmod: 2025-11-18 08:29:59
status_changed: 2025-11-18 08:29:59
type: article
metadata_visibility: show
creators_name: Hadi Sunaryo, Hadi
creators_name: Elly Wardani, Elly
creators_name: Hariyanti, Hariyanti
creators_name: Susilo, Susilo
creators_id: hadisunaryo@uhamka.ac.id
creators_id: hariyanti@uhamka.ac.id
creators_id: susilo@uhamka.ac.id
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0001-7236-563X
corp_creators: UHAMKA
corp_creators: UHAMKA
corp_creators: UHAMKA
corp_creators: UHAMKA
title: NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS
ispublished: pub
subjects: D1
divisions: 48201
abstract: Carica papaya seeds contain flavonoid compounds, saponins, tannins, and anthocyanins that function as anti-hyperlipidemic. This study aims to determine the effect of giving nanosuspension C. papaya seed extract on reducing levels of total cholesterol, LDL-cholesterol, triglycerides, and an increase in HDL-cholesterol in hamster blood induced by high-fat feed. The animals carried out for testing were randomly divided into seven treatment groups, namely the standard group, the opposing group was only given high-fat flour, the positive group was assigned atorvastatin 2.42 mg/kg body weight, and three test groups were given consistent preparations of C. papaya seed extract at a dose of 2.4% each; 4,8%; 9.6% and the test group was assigned a trial of C. papaya seed extract of 240 mg/kg body weight. Activities the administration of test preparations is carried out for 14 days. Measurement of lipid propyl levels using a clinical spectrophotometer. Test data analysis using one-way ANOVA statistics. All doses of C. papaya seed extract nanosuspension preparations were significantly able to lower levels of total cholesterol, LDL-cholesterol, and triglycerides, and increase HDL-cholesterol (p ≤ 0.05) compared to negative controls in hyperlipidemia hamsters. Dose 3 nanosuspension preparations (9.6%) were significantly able to lower levels of total cholesterol, LDL, and triglycerides and increase HDL-cholesterol levels (p ≤ 0.05) compared to negative controls and were comparable to positive controls of atorvastatin (p ≥ 0.05).
full_text_status: public
publication: Eur. Chem. Bull.
refereed: TRUE
citation:   Hadi Sunaryo, Hadi dan Elly Wardani, Elly dan Hariyanti, Hariyanti dan Susilo, Susilo   NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS.  Eur. Chem. Bull..       
document_url: http://repository.uhamka.ac.id/id/eprint/48467/1/ECB-2022-Nanosuspensi%20Carica%20papaya.pdf