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NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS
Carica papaya seeds contain flavonoid compounds, saponins, tannins, and anthocyanins that function as anti-hyperlipidemic. This study aims to determine the effect of giving nanosuspension C. papaya seed extract on reducing levels of total cholesterol, LDL-cholesterol, triglycerides, and an increase in HDL-cholesterol in hamster blood induced by high-fat feed. The animals carried out for testing were randomly divided into seven treatment groups, namely the standard group, the opposing group was only given high-fat flour, the positive group was assigned atorvastatin 2.42 mg/kg body weight, and three test groups were given consistent preparations of C. papaya seed extract at a dose of 2.4% each; 4,8%; 9.6% and the test group was assigned a trial of C. papaya seed extract of 240 mg/kg body weight. Activities the administration of test preparations is carried out for 14 days. Measurement of lipid propyl levels using a clinical spectrophotometer. Test data analysis using one-way ANOVA statistics. All doses of C. papaya seed extract nanosuspension preparations were significantly able to lower levels of total cholesterol, LDL-cholesterol, and triglycerides, and increase HDL-cholesterol (p ≤ 0.05) compared to negative controls in hyperlipidemia hamsters. Dose 3 nanosuspension preparations (9.6%) were significantly able to lower levels of total cholesterol, LDL, and triglycerides and increase HDL-cholesterol levels (p ≤ 0.05) compared to negative controls and were comparable to positive controls of atorvastatin (p ≥ 0.05).
NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS (Text)
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Fakultas Farmasi dan Sains