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primary topic: NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS

NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS
type: AcademicArticle
type: Article
abstract: Carica papaya seeds contain flavonoid compounds, saponins, tannins, and anthocyanins that function as anti-hyperlipidemic. This study aims to determine the effect of giving nanosuspension C. papaya seed extract on reducing levels of total cholesterol, LDL-cholesterol, triglycerides, and an increase in HDL-cholesterol in hamster blood induced by high-fat feed. The animals carried out for testing were randomly divided into seven treatment groups, namely the standard group, the opposing group was only given high-fat flour, the positive group was assigned atorvastatin 2.42 mg/kg body weight, and three test groups were given consistent preparations of C. papaya seed extract at a dose of 2.4% each; 4,8%; 9.6% and the test group was assigned a trial of C. papaya seed extract of 240 mg/kg body weight. Activities the administration of test preparations is carried out for 14 days. Measurement of lipid propyl levels using a clinical spectrophotometer. Test data analysis using one-way ANOVA statistics. All doses of C. papaya seed extract nanosuspension preparations were significantly able to lower levels of total cholesterol, LDL-cholesterol, and triglycerides, and increase HDL-cholesterol (p ≤ 0.05) compared to negative controls in hyperlipidemia hamsters. Dose 3 nanosuspension preparations (9.6%) were significantly able to lower levels of total cholesterol, LDL, and triglycerides and increase HDL-cholesterol levels (p ≤ 0.05) compared to negative controls and were comparable to positive controls of atorvastatin (p ≥ 0.05).
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS (Text)
subject: Fakultas Farmasi dan Sains

NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS (Text)
type: Document
has file: ECB-2022-Nanosuspensi Carica papaya.pdf
has part: ECB-2022-Nanosuspensi Carica papaya.pdf

Eur. Chem. Bull.
type: Collection

Susilo Susilo
type: Person
given name: Susilo
family name: Susilo

Hadi Hadi Sunaryo
type: Person
given name: Hadi
family name: Hadi Sunaryo

Elly Elly Wardani
type: Person
given name: Elly
family name: Elly Wardani

Hariyanti Hariyanti
type: Person
given name: Hariyanti
family name: Hariyanti

UHAMKA
type: Organization

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primary topic: NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS

Fakultas Farmasi dan Sains
type: Concept