eprintid: 482
rev_number: 54
eprint_status: archive
userid: 1
dir: disk0/00/00/04/82
datestamp: 2018-05-28 07:08:53
lastmod: 2021-11-28 09:40:12
status_changed: 2021-11-28 09:40:12
type: article
metadata_visibility: show
creators_name: Siska, Siska
creators_id: siska@uhamka.ac.id
creators_orcid: 0000-0003-4830-9261
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_name: Sunaryo, Hadi
contributors_name: Siska, Siska
contributors_name: Dwitiyanti, Dwitiyanti
contributors_name: Arcinthya Rahmania, Rizky
corp_creators: UHAMKA
title: COMBINATION OF GINGER EXTRACT (Zingiber officinale Roscoe) AND ZINC AS METABOLIC SYNDROME IN HIGH CHOLESTEROL DIET DIABETIC MICE
ispublished: pub
subjects: Q1
abstract: Metabolic syndrome including the presence of obesity, insulin resistance and dyslipidemia that predisposes type 2 diabetes. The puipose of this study to prove the effectiveness of the combination of the ethanol extract of ginger (Zingiber officinale Roscoe) with Zinc (Zn) as a hypolipidemia, and hypoglycemia through the measurement of oxidized LDL, total cholesterol, triglycerides in diabetic mice fed high-cholesterol diet. This study used 54 male mice were divided into 9 groups: normal control group, negative control, positive control, ginger extract (ZO) group dose of 37.5 mg/kg, Zn 20 mg/kg and five groups with a test dose variation that ginger dose 1 (37.5 mg/kg) + Zn 20 mg/kg, ginger dose 2 (75 mg/kg) + Zn 20 mg/kg, ginger dose 3(150 mg/kg) + Zn 20 mg/kg of each test group given the extract for 14 days. Animal models used were mice induced by streptozotocin (STZ) and feed hypercholesterolemia. The results obtained from this study, combined with ginger extract 75 mg/kg and zinc 20 mg/kg can lower blood glucose levels by 39.87 %, comparable to metformin (p > 0.05). The combination of ginger extract 75 mg/kg with zinc 20 mg/kg can lower total cholesterol 65.88%, LDL cholesterol 74.62% and triglyceride levels 55.41%, comparable to atorvastatin (p > 0.05). The addition of Zn to ginger (ZO) extract can increase hypolipidemia activity and hypoglycemic activity of ginger extract.
date: 2016
date_type: published
publisher: Faculty Of Pharmacy and science
full_text_status: public
pagerange: 5-11
refereed: TRUE
isbn: 978-602-71959-2-9
book_title: METABOLIC SYNDROME: NOW AND FUTURE TREND
citation:   Siska, Siska  (2016) COMBINATION OF GINGER EXTRACT (Zingiber officinale Roscoe) AND ZINC AS METABOLIC SYNDROME IN HIGH CHOLESTEROL DIET DIABETIC MICE.    pp. 5-11.      
document_url: http://repository.uhamka.ac.id/id/eprint/482/7/16.pdf
document_url: http://repository.uhamka.ac.id/id/eprint/482/9/COMBINATION%20OF%20GINGER%20EXTRACT%20%28Zingiber%20officinale%20Roscoe%29%20AND%20ZINC%20AS%20METABOLIC%20SYNDROME%20IN%20HIGH%20CHOLESTEROL%20DIET%20DIABETIC%20MICE.pdf
document_url: http://repository.uhamka.ac.id/id/eprint/482/25/16.%20PR%20Prosiding%20Ginger%202016.pdf