TY  - JOUR
VL  - 66
ID  - repository4703
UR  - https://content.sciendo.com/view/journals/afpuc/afpuc-overview.xml
EP  - 31
SP  - 26
AV  - public
A1  - Siska, Siska
IS  - 2
TI  - Evaluation of analgesic and anti-inflammatory activities of
ethanolic extract of Cordia sebestena L.
Y1  - 2019///
SN  - 1338-6786
PB  - Sciendo
JF  - Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.
N2  - Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study
was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats.
The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory
activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract
(100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The
extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained
support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further
scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and
clinical settings.
ER  -