eprintid: 4569
rev_number: 8
eprint_status: archive
userid: 1610
dir: disk0/00/00/45/69
datestamp: 2020-11-05 04:16:57
lastmod: 2020-11-05 04:16:57
status_changed: 2020-11-05 04:16:57
type: article
metadata_visibility: show
creators_name: Fahjar Prisiska, Fahjar
creators_name: Inding, Gusmayadi
creators_id: fahjar.prisiska@uhamka.ac.id
creators_id: indinggusmayadi@uhamka.ac.id
creators_orcid: 0000-0003-4756-8376
title: COMPARISON OF MANNITOL, LACTOSE, AND SUCROSE AS FILLER ORALLY DISINTEGRATING TABLETS DIMENHYDRINAT
ispublished: submitted
subjects: HD
divisions: 12
abstract: Dimenhidrinat is one of active substance which can cure the pale. However, not all people can consume the tablet of dimenhidrinat easily. The difficulty to swallow tablet is a problem that happens. Therefore, the presence of ODT was absolutely needed because ODT can conceal the taste of dimenhidrinat (active substance) and help patients who have difficulty to swallow the tablet. The purpose of this research was to find out the usage of comparison for filler substance (manitol, lactose, and sucrose) toward the influence of characteristic’s ODT dimenhidrinat. This tablet was formulated by doing comparison manitol, lactose, sucrose
1:0:0, 0:1:0, 0:0:1, 1:1:0, 0:1:1, 1:0:1, 1:1:1. The tablet is made by direct molding method. From physical test of ODT like hardness test (2,2-4,7kg), friability (0,24-0,81%), weight uniformity (0,1825-0,2202 gram),   modified shattered time (31,47-143,33 second),   and ingredient uniformity test (95,35-108,18%). Based on Independent test with confidence level
95% (α= 0,05), the quickest shattered time is in formula 7 by comparison of filler substance manitol, lactose, and sucrose (1:1:1)

Keyword :Orally Disintegrating Tablet, Filler Substance, Dimenhidrinat
date: 2015-08-03
date_type: submitted
full_text_status: public
publication: INTERNATIONAL SEMINAR ON PHARMACEUTICS 2015
refereed: FALSE
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citation:   Fahjar Prisiska, Fahjar dan Inding, Gusmayadi  (2015) COMPARISON OF MANNITOL, LACTOSE, AND SUCROSE AS FILLER ORALLY DISINTEGRATING TABLETS DIMENHYDRINAT.  INTERNATIONAL SEMINAR ON PHARMACEUTICS 2015.      (Submitted)  
document_url: http://repository.uhamka.ac.id/id/eprint/4569/1/artikel%20seminar%20ITB%202015.docx