eprintid: 45171
rev_number: 7
eprint_status: archive
userid: 1762
dir: disk0/00/04/51/71
datestamp: 2025-07-22 06:55:58
lastmod: 2025-07-22 06:55:58
status_changed: 2025-07-22 06:55:58
type: article
metadata_visibility: show
creators_name: Lestari, Pramulani
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_name: , 
contributors_name: , 
contributors_name: Lestari, Pramulani
contributors_name: , 
contributors_name: , 
contributors_id: pramulani_mlestari@uhamka.ac.id
title: NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS
ispublished: pub
subjects: RS
divisions: 48201
abstract: Carica papaya seeds contain flavonoid compounds, saponins, tannins, and anthocyanins that function as antihyperlipidemic. This study aims to determine the effect of giving nanosuspension C. papaya seed extract on reducing levels of
total cholesterol, LDL-cholesterol, triglycerides, and an increase in HDL-cholesterol in hamster blood induced by high-fat feed.
The animals carried out for testing were randomly divided into seven treatment groups, namely the standard group, the opposing
group was only given high-fat flour, the positive group was assigned atorvastatin 2.42 mg/kg body weight, and three test groups
were given consistent preparations of C. papaya seed extract at a dose of 2.4% each; 4,8%; 9.6% and the test group was assigned
a trial of C. papaya seed extract of 240 mg/kg body weight. Activities the administration of test preparations is carried out for 14
days. Measurement of lipid propyl levels using a clinical spectrophotometer. Test data analysis using one-way ANOVA statistics.
All doses of C. papaya seed extract nanosuspension preparations were significantly able to lower levels of total cholesterol, LDLcholesterol, and triglycerides, and increase HDL-cholesterol (p ≤ 0.05) compared to negative controls in hyperlipidemia
hamsters. Dose 3 nanosuspension preparations (9.6%) were significantly able to lower levels of total cholesterol, LDL, and
triglycerides and increase HDL-cholesterol levels (p ≤ 0.05) compared to negative controls and were comparable to positive
controls of atorvastatin (p ≥ 0.05).
date: 2022
date_type: published
official_url: https://www.bibliomed.org/?mno=118686
full_text_status: public
publication: BiblioMed
volume: 11
number: 7
pagerange: 6-14
refereed: TRUE
citation:   Lestari, Pramulani  (2022) NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS.  BiblioMed, 11 (7).  pp. 6-14.      
document_url: http://repository.uhamka.ac.id/id/eprint/45171/1/2022_NANOSUSPENSION%20OF%20CARICA%20PAPAYA%20L.%20SEED%20EXTRACT%20FOR%20ANTI-HYPERLIPIDEMIC%20PROPYL%20LIPIDS%20IN%20HYPERLIPIDEMIC%20HAMSTERS.pdf