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primary topic: NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS

NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS
type: AcademicArticle
type: Article
abstract: Carica papaya seeds contain flavonoid compounds, saponins, tannins, and anthocyanins that function as antihyperlipidemic. This study aims to determine the effect of giving nanosuspension C. papaya seed extract on reducing levels of total cholesterol, LDL-cholesterol, triglycerides, and an increase in HDL-cholesterol in hamster blood induced by high-fat feed. The animals carried out for testing were randomly divided into seven treatment groups, namely the standard group, the opposing group was only given high-fat flour, the positive group was assigned atorvastatin 2.42 mg/kg body weight, and three test groups were given consistent preparations of C. papaya seed extract at a dose of 2.4% each; 4,8%; 9.6% and the test group was assigned a trial of C. papaya seed extract of 240 mg/kg body weight. Activities the administration of test preparations is carried out for 14 days. Measurement of lipid propyl levels using a clinical spectrophotometer. Test data analysis using one-way ANOVA statistics. All doses of C. papaya seed extract nanosuspension preparations were significantly able to lower levels of total cholesterol, LDLcholesterol, and triglycerides, and increase HDL-cholesterol (p ≤ 0.05) compared to negative controls in hyperlipidemia hamsters. Dose 3 nanosuspension preparations (9.6%) were significantly able to lower levels of total cholesterol, LDL, and triglycerides and increase HDL-cholesterol levels (p ≤ 0.05) compared to negative controls and were comparable to positive controls of atorvastatin (p ≥ 0.05).
date: 2022
volume: 11
issue: 7
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS (Text)
has version: NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS (Text)
has published: NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS (Text)
subject: RS Pharmacy and materia medica

NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS (Text)
type: Document
has file: 2022_NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS.pdf
has part: 2022_NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS.pdf

BiblioMed
type: Collection

Pramulani Lestari
type: Person
given name: Pramulani
family name: Lestari

Pramulani Lestari
type: Person
given name: Pramulani
family name: Lestari

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primary topic: NANOSUSPENSION OF CARICA PAPAYA L. SEED EXTRACT FOR ANTI-HYPERLIPIDEMIC PROPYL LIPIDS IN HYPERLIPIDEMIC HAMSTERS

RS Pharmacy and materia medica
type: Concept