eprintid: 45166
rev_number: 6
eprint_status: archive
userid: 1762
dir: disk0/00/04/51/66
datestamp: 2025-07-22 04:43:29
lastmod: 2025-07-22 04:43:29
status_changed: 2025-07-22 04:43:29
type: article
metadata_visibility: show
creators_name: Lestari, Pramulani Mulya
creators_name: Widayanti, Ari
creators_id: pramulani_mlestari@uhamka.ac.id
creators_id: ariwidayanti@uhamka.ac.id
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_name: Lestari, Pramulani
contributors_name: Widayanti, Ari
contributors_id: pramulani_mlestari@uhamka.ac.id
contributors_id: ariwidayanti@uhamka.ac.id
title: The Effect of Pregelatinized Taro Starch (Colocasia Esculenta 
(L.) Schott) Temperature as Filler on Thiamine Hidrochloride 
Tablet
ispublished: pub
subjects: RS
divisions: 48201
abstract: BACKGROUND: Pregelatinizing is processed to modify structure of starch by heating a certain temperature. Increasing of temperature causes the starch to absorb water and swell quickly in order to obtain a larger particle size. Larger particle size will improve the flowability and compressibility of the granules. Pregelatinized taro starch is used as diluent tablets with wet granulation method.

AIM: The objective research was to determine the effect of increasing pregelatinized taro starch temperature as diluent on compressibility and comprimability granule of thiamine hidrochloride compression.

METHODS: Pregelatinized taro starch is made by heating the suspension of starch at 50°C, 60°C and 70°C for 10 minutes and then dried. Pregelatinized taro starch is used as a filler of Thiamine Hidrocloride tablets which made by wet granulation method. Test wereperformed for each formula such as quality tests of granules and tablets physical properties and assay.

RESULT: Granule compressibility evaluation results show that the formula 1, 2, and 3 qualified with compressibility value is 7.9941 respectively; 6.9929; and 5.9950%. From the results of the one-way ANOVA analysis of the compressibility obtained sig. 0,000 less than 0.05, then there is a significant difference between formula one with the other formulas.

CONCLUSION: It shows the difference in temperature affect the compressibility pregelatinized taro starch. The higher the temperature of pregelatinized taro starch, produces tablets with low compressibility.
date: 2019-11-30
date_type: published
publisher: Sciendo
official_url: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.513
full_text_status: public
publication: Open Access Macedonian Journal of Medical Sciences (OAMJMS)
volume: 7
number: 22
pagerange: 3827-3832
refereed: TRUE
issn: 1857-9655
citation:   Lestari, Pramulani Mulya dan Widayanti, Ari  (2019) The Effect of Pregelatinized Taro Starch (Colocasia Esculenta (L.) Schott) Temperature as Filler on Thiamine Hidrochloride Tablet.  Open Access Macedonian Journal of Medical Sciences (OAMJMS), 7 (22).  pp. 3827-3832.  ISSN 1857-9655     
document_url: http://repository.uhamka.ac.id/id/eprint/45166/1/2019_The%20Effect%20of%20Pregelatinized%20Taro%20Starch%20%28Colocasia%20Esculenta%20%28L.%29%20Schott%29%20Temperature%20as%20Filler%20on%20Thiamine%20Hidrochloride%20Tablet.pdf