@article{repository45166,
           title = {The Effect of Pregelatinized Taro Starch (Colocasia Esculenta 
(L.) Schott) Temperature as Filler on Thiamine Hidrochloride 
Tablet},
          volume = {7},
           pages = {3827--3832},
            year = {2019},
         journal = {Open Access Macedonian Journal of Medical Sciences (OAMJMS)},
           month = {November},
       publisher = {Sciendo},
          number = {22},
             url = {https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.513},
          author = {Lestari, Pramulani Mulya and Widayanti, Ari},
            issn = {1857-9655},
        abstract = {BACKGROUND: Pregelatinizing is processed to modify structure of starch by heating a certain temperature. Increasing of temperature causes the starch to absorb water and swell quickly in order to obtain a larger particle size. Larger particle size will improve the flowability and compressibility of the granules. Pregelatinized taro starch is used as diluent tablets with wet granulation method.

AIM: The objective research was to determine the effect of increasing pregelatinized taro starch temperature as diluent on compressibility and comprimability granule of thiamine hidrochloride compression.

METHODS: Pregelatinized taro starch is made by heating the suspension of starch at 50{\^A}oC, 60{\^A}oC and 70{\^A}oC for 10 minutes and then dried. Pregelatinized taro starch is used as a filler of Thiamine Hidrocloride tablets which made by wet granulation method. Test wereperformed for each formula such as quality tests of granules and tablets physical properties and assay.

RESULT: Granule compressibility evaluation results show that the formula 1, 2, and 3 qualified with compressibility value is 7.9941 respectively; 6.9929; and 5.9950\%. From the results of the one-way ANOVA analysis of the compressibility obtained sig. 0,000 less than 0.05, then there is a significant difference between formula one with the other formulas.

CONCLUSION: It shows the difference in temperature affect the compressibility pregelatinized taro starch. The higher the temperature of pregelatinized taro starch, produces tablets with low compressibility.}
}