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primary topic: Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability

Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability
type: AcademicArticle
type: Article
abstract: As a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is added with a thickening agent to create transdermal dosage form. This study aimed to compare the physical stabilities of ketoconazole microemulsions formed with different thickeners, namely Carbopol 934 and Carbopol 941. The formula used varying concentrations of Carbopol 934 and Carbopol 941, i.e., 0.15% and 0.25%. The stability was observed during eight-week storage in which the conditions were controlled by different degrees of temperature, i.e., 40C, 25-300C (room temperature), and 400C. The stability tests included organoleptic observation, pH, surface tension, viscosity, particle size, and zeta potential. Based on the Kruskal-Wallis test results, ketoconazole microemulsion with Carbopol 941 that had been stored in different temperature showed a significant difference in particle size (significance value< 0.05), but it did not apply to Carbopol 934. The evaluation revealed that compared to 0.25% of Carbopol 934, microemulsion with 0.15% of Carbopol 934 had a smaller difference between the time intervals. This research concluded that the use of 0.15% of Carbopol 934 as a thickener in ketoconazole microemulsion had better physical stability compared to Carbopol 941 due to the influence of temperature and length of storage.
date: 2018-05
volume: 8
issue: 1
is part of: Pharmaciana
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability (Text)
subject: RL Dermatology

Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability (Text)
type: Document
has file: 2018_Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability.pdf
has part: 2018_Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability.pdf

Universitas Ahmad Dahlan
type: Organization

Pharmaciana
type: Collection
issn: 24770256

Kori Yati
type: Person
given name: Kori
family name: Yati

Pramulani Lestari
type: Person
given name: Pramulani
family name: Lestari

HTML Summary of #45136 Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability
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primary topic: Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability

RL Dermatology
type: Concept