eprintid: 45046
rev_number: 10
eprint_status: archive
userid: 1762
dir: disk0/00/04/50/46
datestamp: 2025-07-21 01:15:46
lastmod: 2025-07-21 01:15:46
status_changed: 2025-07-21 01:15:46
type: article
metadata_visibility: show
creators_name: Lestari, Pramulani Mulya
creators_id: pramulani_mlestari@uhamka.ac.id
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
contributors_name: Lestari, Pramulani Mulya
contributors_id: pramulani_mlestari@uhamka.ac.id
title: Development of transethosomes patch for delivery atorvastatin
 calcium transdermally: In vitro and in vivo studies
ispublished: pub
subjects: R
divisions: 48201
abstract: Atorvastatin calcium is an antihyperlipidemic with low bioavailability, and to address this limitation, a trans
dermal delivery system utilizing transethosomes as a carrier was developed. This study aimed to enhance the bioavailability of atorvastatin calcium by transitioning from oral to transdermal administration. The six different formulas of transethosomes were observed based on particle size, PDI, zeta potential, deformability index, and morphology. Furthermore, the patch’s characteristics, penetration, pharmacokinetic, and irritation
 studies of transethosomes patch were observed. The results showed that atorvastatin calcium transetho
somes had a particle size of ≤ 130.59 nm with PDI and zeta potential values of ≤ 0.24 and ≥ 51.87 mV,
 respectively. The vesicles featured spherical morphology and an excellent deformability index. The transe
thosome patches obtained had a pH and viscosity value of 5.7 and ≥ 8741 mPa.s, respectively. The properties of transethosomes loaded in the patch were observed to show a particle size of ≤ 249.83 nm and zeta potential ≥ 44.73 mV. A penetration study of the atorvastatin calcium transethosomes patch reveals high flux, especially the G6 formula, increasing bioavailability by 3.67-fold and not irritating. In conclusion, developing a transethosomes patch for transdermal delivery proved to be an effective method for enhancing the bioavailability of atorvastatin calcium.
date: 2025-02
date_type: published
publisher: sciencedirect
official_url: https://www.scopus.com/sourceid/23079#tabs=1
full_text_status: public
publication: Atorvastatin calcium is an antihyperlipidemic with low bioavailability, and to address this limitation, a trans dermal delivery system utilizing transethosomes as a carrier was developed. This study aimed to enhance  the bioavailability of atorvastatin c
volume: 114
refereed: TRUE
issn: 0022-3549
related_url_type: pub
citation:   Lestari, Pramulani Mulya  (2025) Development of transethosomes patch for delivery atorvastatin calcium transdermally: In vitro and in vivo studies.  Atorvastatin calcium is an antihyperlipidemic with low bioavailability, and to address this limitation, a trans dermal delivery system utilizing transethosomes as a carrier was developed. This study aimed to enhance the bioavailability of atorvastatin c, 114.   ISSN 0022-3549     
document_url: http://repository.uhamka.ac.id/id/eprint/45046/1/abstrak_repository.pdf