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primary topic: Development of transethosomes patch for delivery atorvastatin calcium transdermally: In vitro and in vivo studies

Development of transethosomes patch for delivery atorvastatin calcium transdermally: In vitro and in vivo studies
type: AcademicArticle
type: Article
abstract: Atorvastatin calcium is an antihyperlipidemic with low bioavailability, and to address this limitation, a trans dermal delivery system utilizing transethosomes as a carrier was developed. This study aimed to enhance the bioavailability of atorvastatin calcium by transitioning from oral to transdermal administration. The six different formulas of transethosomes were observed based on particle size, PDI, zeta potential, deformability index, and morphology. Furthermore, the patch’s characteristics, penetration, pharmacokinetic, and irritation studies of transethosomes patch were observed. The results showed that atorvastatin calcium transetho somes had a particle size of ≤ 130.59 nm with PDI and zeta potential values of ≤ 0.24 and ≥ 51.87 mV, respectively. The vesicles featured spherical morphology and an excellent deformability index. The transe thosome patches obtained had a pH and viscosity value of 5.7 and ≥ 8741 mPa.s, respectively. The properties of transethosomes loaded in the patch were observed to show a particle size of ≤ 249.83 nm and zeta potential ≥ 44.73 mV. A penetration study of the atorvastatin calcium transethosomes patch reveals high flux, especially the G6 formula, increasing bioavailability by 3.67-fold and not irritating. In conclusion, developing a transethosomes patch for transdermal delivery proved to be an effective method for enhancing the bioavailability of atorvastatin calcium.
date: 2025-02
volume: 114
is part of: ext-00223549
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Development of transethosomes patch for delivery atorvastatin calcium transdermally: In vitro and in vivo studies (Text)
has version: Development of transethosomes patch for delivery atorvastatin calcium transdermally: In vitro and in vivo studies (Text)
has published: Development of transethosomes patch for delivery atorvastatin calcium transdermally: In vitro and in vivo studies (Text)
subject: R Medicine

Development of transethosomes patch for delivery atorvastatin calcium transdermally: In vitro and in vivo studies (Text)
type: Document
has file: abstrak_repository.pdf
has part: abstrak_repository.pdf

sciencedirect
type: Organization

ext-00223549
type: Collection
name: Atorvastatin calcium is an antihyperlipidemic with low bioavailability, and to address this limitation, a trans dermal delivery system utilizing transethosomes as a carrier was developed. This study aimed to enhance the bioavailability of atorvastatin c
issn: 00223549

Pramulani Mulya Lestari
type: Person
given name: Pramulani Mulya
family name: Lestari

HTML Summary of #45046 Development of transethosomes patch for delivery atorvastatin calcium transdermally: In vitro and in vivo studies
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primary topic: Development of transethosomes patch for delivery atorvastatin calcium transdermally: In vitro and in vivo studies

R Medicine
type: Concept