TY  - JOUR
SN  - 2651-4702
EP  - 982
ID  - repository45045
JF  - Journal of Medicinal and Chemical Sciences
N2  - Atorvastatin calcium is an antihyperlipidemic agent with low 
bioavailability due to the first-pass metabolism after oral administration. 
To overcome the limitation, an alternative method for delivering drug 
molecules to the systemic circulation is needed, such as transethosomes 
produced for transdermal delivery. Therefore, this study aimed to produce 
atorvastatin calcium transethosomes with characteristics suitable for 
transdermal delivery using validated analytical method. Transethosomes 
formulations were prepared with different concentrations of soy lecithin 
and ethanol. All formulations were evaluated for particle size, zeta 
potential, polydispersity index (PDI), drug content, and deformability 
index. Validation of the analytical method of atorvastatin calcium was 
carried out using system suitability, selectivity, linearity, limit of detection 
(LOD), limit of quantification (LOQ), precision, accuracy, and robustness. 
The result showed that transethosomes had a small particle size of 123.90 
nm-165.10 nm, high zeta potential values, acceptable PDI, the highest 
atorvastatin calcium content, and good deformability index. In addition, 
the system suitability test results were acceptable and there was no 
interference in the atorvastatin calcium area. Linearity showed r =0.9999 
with LOD and LOQ values of 0.388 µg/mL and 1.176 µg/mL, respectively. 
The % RSD in the precision was < 2 and the recovery in the accuracy was 
98.76%-101.04%. The method proved to be robust with respect to mobile 
phase pH changes. Based on the results, atorvastatin calcium-loaded 
transethosomes were suitable for transdermal delivery and could be 
effectively produced with a 3% soy lecithin and 30% ethanol 
concentration. The analytical method for determining drug content of 
atorvastatin calcium-loaded transethosomes could be effectively applied.
A1  - Lestari, Pramulani Mulya
TI  - An Investigation of Atorvastatin Calcium Loaded Transethosomes 
for Transdermal Delivery and Validation of HPLC Methods
PB  - Sami Publishing Company (SPC)
VL  - 7
Y1  - 2024///
IS  - 7
UR  - https://www.jmchemsci.com/
AV  - public
SP  - 969
ER  -