?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Frepository.uhamka.ac.id%2Fid%2Feprint%2F4214%2F&rft.title=EFFECT+OF+OPTIMIZATION+OF+TWEEN+80+AND+PROPYLENE+GLYCOL+AS+A+SURFACTANT+AND%0D%0ACOSURFACTANT+ON+THE+PHYSICAL+PROPERTIES+OF+ASPIRIN+MICROEMULSION&rft.creator=YATI%2C+KORI&rft.subject=H+Social+Sciences&rft.description=Background%3A+Aspirin+is+recommended+as+a+first-line+antiplatelet+drug+for+all+types+of+acute+diseases+that+cause+thrombosis+in+the+blood+vessel%2C%0D%0Aespecially+in+cardiovascular+disease.+Orally+administered+aspirin+has+side+effects+such+as+the+risk+of+gastrointestinal+bleeding+and+has+presystemic%0D%0Ametabolism+in+the+gastrointestinal+tract+and+liver.+Transdermal+delivery+offers+an+alternative+for+administering+aspirin+that+by+passes+the+gut+and+this%0D%0Amay+be+more+convenient+and+safe+for+long-term+use.+This+study+used+a+form+of+microemulsion+to+prevent+hydrolysis+of+aspirin+because+it+contains+a%0D%0Ahigh+concentration+of+the+surfactant.+A+microemulsion+is+a+dosage+form+that+can+penetrate+into+the+skin+for+transdermal+delivery.%0D%0AObjectives%3A+The+aim+of+this+research+was+to+evaluate+the+effect+of+Tween+80+and+propylene+glycol+as+the+surfactant+and+cosurfactant+on+the+physical%0D%0Astability+of+the+microemulsion.%0D%0AMaterials+and+Methods%3A+Various+concentrations+of+Tween+80+and+propylene+glycol+(2%3A1)+were+used+54%25%2C+57%25%2C+60%25%2C+and+63%25%2C+and+the+physical%0D%0Astability+of+the+different+microemulsions+was+tested+for+6+weeks.%0D%0AResult%3A+The+results+showed+that+the+formula+F3+was+the+most+stable+formula.+The+formula+F3+showed+the+following+properties+such+as+pH+of+3.74%C2%B10.30%2C%0D%0Aviscosity+of+1198.76%C2%B156.02+cps%2C+BJ+of+1.0669%C2%B10.005+g%2FmL%2C+surface+tension+of+38.77%C2%B10.43+dyne%2Fcm%2C+and+particle+size+of+49.46%C2%B16.91+nm.%0D%0AConclusions%3A+Based+on+the+results+concluded+that+the+optimum+concentration+of+Tween+80+as+the+surfactant+and+propylene+glycol+as+the+cosurfactant%0D%0Awith+a+ratio+of+2%3A1+was+60%25.&rft.publisher=Innovare+Academic+Sciences+Pvt.+Ltd.&rft.date=2017-07-13&rft.type=Other&rft.type=NonPeerReviewed&rft.format=text&rft.language=en&rft.identifier=http%3A%2F%2Frepository.uhamka.ac.id%2Fid%2Feprint%2F4214%2F1%2FIjap%2520Upload.pdf&rft.format=text&rft.language=en&rft.identifier=http%3A%2F%2Frepository.uhamka.ac.id%2Fid%2Feprint%2F4214%2F2%2FPeer%2520review%25201.pdf&rft.format=text&rft.language=en&rft.identifier=http%3A%2F%2Frepository.uhamka.ac.id%2Fid%2Feprint%2F4214%2F3%2FPeer%2520review%25202.pdf&rft.format=text&rft.language=en&rft.identifier=http%3A%2F%2Frepository.uhamka.ac.id%2Fid%2Feprint%2F4214%2F4%2FTurnitin%2520IJAP.pdf&rft.identifier=++YATI%2C+KORI++(2017)+EFFECT+OF+OPTIMIZATION+OF+TWEEN+80+AND+PROPYLENE+GLYCOL+AS+A+SURFACTANT+AND+COSURFACTANT+ON+THE+PHYSICAL+PROPERTIES+OF+ASPIRIN+MICROEMULSION.++Innovare+Academic+Sciences+Pvt.+Ltd..+++++&rft.relation=https%3A%2F%2Finnovareacademics.in%2Fjournals%2Findex.php%2Fijap%2Farticle%2Fview%2F23312