%0 Journal Article
%@ 22180532, 00368709
%A Siska, Siska
%A Universitas Muhammadiyah Prof. Dr. HAMKA,
%D 2018
%F repository:416
%I MDPI
%J Scientia Pharmaceutica
%T Effect of Apium graveolens Extract Administration on the Pharmacokinetics of Captopril in the Plasma of Rats
%U http://repository.uhamka.ac.id/id/eprint/416/
%V 86(1)
%X Apium graveolens (celery) is an edible and traditionally medicinal plant that is used  worldwide, among others for the treatment of hypertension. Combining celery with antihypertensive  drugs can affect the pharmacodynamics and pharmacokinetics of the latter drugs. The aim of the  study is to assess the effects of administrating the celery extract on captopril pharmacokinetics.  Sprague-Dawley strain rats were divided into two groups (n = 6). Group I was given captopril  (10 mg/kg Body Weight (BW)) orally, while Group II was pretreated with celery extract orally  (40 mg/kg BW) an hour before administration of captopril. The blood samples were withdrawn  at various intervals after drug administration. The captopril concentration was determined using  liquid chromatography–mass spectrometry (LC-MS/MS) and from the blood data, the values of Ke,  Cmax, Tmax, T1/2, and area under the curve (AUC) were calculated. The results showed that oral  administration of the celery extract increased Cmax (38.67%), T1/2 (37.84%), and AUC (58.10%) and  decreased Ke (27.45%) of captopril in Group II (celery + captopril) compared with Group I (captopril).  In conclusion, celery extract can alter the pharmacokinetic of captopril when given in combination.  The combination might be beneficial for the treatment of hypertension, as celery causes an increase in  the plasma level of captopril, which can enhance its efficacy