eprintid: 41264
rev_number: 9
eprint_status: archive
userid: 2338
dir: disk0/00/04/12/64
datestamp: 2025-01-28 01:59:19
lastmod: 2025-01-28 01:59:19
status_changed: 2025-01-28 01:59:19
type: thesis
metadata_visibility: show
creators_name: Tuti, Sugiarti
creators_name: Iis, Afriayani
creators_name: Sri, Wahyuni Handayani
title: HUBUNGAN PROTROMBIN TIME, ACTIVED PARTIAL
THROMBOPLASTIN TIME DAN D-dimer PADA PASIEN
COVID-19 DI RSUD PASAR REBO
ispublished: pub
subjects: RS
divisions: 13353
abstract: HUBUNGAN PROTROMBIN TIME, ACTIVATED PARTIAL
THROMBOPLASTIN TIME DAN D-dimer PADA PASIEN
COVID-19 DI RSUD PASAR REBO
Tuti sugiarti
1804034007
Coronavirus Disease 2019 (Covid-19) merupakan penyakit infeksi yang
disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus-2 (SARSCOV-
2) dengan manifestasi klinis utama infeksi akut saluran pernapasan.
Sebanyak 38.277 kasus positif dan 2.134 kematian di Jakarta pada tahun 2022.
Tingginya angka kematian pada infeksi Covid karena menginfeksi saluran
pernafasan virus ini mengakibatkan gangguan pembekuan darah. Tujuan dari
penelitian ini untuk mengetahui hubungan kadar PT (Protrombin Time), APPT
(Actived Patrial Tharomboplastin Time) dan D-dimer pada pasien Covid pada
gejala berat dan kritis di RSUD Pasar Rebo. Penelitian ini merupakan penelitian
observasional dengan metode cross sectional. Hasil penelitian dilakukan pada 100
pasien didapatkan hasil uji chi-square terdapat hubungan antara pemeriksaan PT
dengan infeksi Covid-19 (p value= 0,000), terdapat hubungan antara APPT
dengan infeksi Covid-19 (p value = 0,020) dan terdapat hubungan antara D-dimer
dengan infeksi Covid-19 (p value = 0,32). Kesimpulan, hasil pemeriksaan PT,
APPT dan D-Dimer yang tidak normal memiliki hubungan dengan infeksi Covid
19.
Kata kunci : Actived Patrial Tharomboplastin Time (APPT), Covid-19 D-dimer,
koagulapati, protrombin time (PT).
date: 2022
date_type: completed
full_text_status: public
institution: UNIVERSITAS MUHAMMADIYAH PROF. DR. HAMKA
department: FAKULTAS FARMASI DAN SAINS
thesis_type: bachelor
thesis_name: bphil
referencetext: Adimara, Annas, Kartika Prahasanti, and Muhammad Perdana Airlangga. 2021.
“Obesitas Mempengaruhi Tingkat Keparahan Pasien Covid-19.” Online)
Jurnal Ilmiah Kedokteran Wijaya Kusuma 10(2): 222–42.
Aditia, Arianda. 2021. “Covid-19 : Epidemiologi, Virologi, Penularan, Gejala
Klinis, Diagnosa, Tatalaksana, Faktor Risiko Dan Pencegahan.” Jurnal
Penelitian Perawat Profesional 3(November): 653–60.
http://jurnal.globalhealthsciencegroup.com/index.php/JPPP%0A Covid-19.
Anggraeni, Novita. 2021. “Manajemen Koagulopati Pada Pasien Covid-19.”
(September).
Bintoro, Siprianus Ugroseno Yudho et al. 2021. “Hematologic and Coagulopathy
Parameter as a Survival Predictor among Moderate to Severe Covid-19
Patients in Non- ICU Ward: A Single-Center Study at the Main Referral
Hospital in Surabaya, East Java, Indonesia.” F1000Research 10.
Felicia, Vania, Fabiola. 2020. “Manifestasi Klinis Infeksi Covid-19 Pada Anak.”
Cermin Dunia Kedokteran 47(6): 420–23.
http://www.cdkjournal.com/index.php/CDK/article/view/774.
Grace, Celine. 2020. “Manifestasi Klinis Dan Perjalanan Penyakit Pada Pasien
Covid-19.” Majority 9: 49–55.
Guan, Wei-jie 2020. “Clinical Characteristics of Coronavirus Disease 2019 in
China.” New England Journal of Medicine 382(18): 1708–20.
Harapan, Harapan 2020. “Coronavirus Disease 2019 (Covid-19): A Literature
Review ," Journal of Infection and Public Health.” Journal of Infection and
Public Health 13(January): 667–73.
Hidayati, Deny. 2020. “Profil Penduduk Terkonfirmasi Positif Covid-19 Dan
Meninggal: Kasus Indonesia Dan Dki Jakarta.” Jurnal Kependudukan
Indonesia 2902: 93.
Kahar, Hartono, and Nabil Salim. 2021 “Kelainan Hemostasis Pada Pasien Covid-
19.” Prosidingsemonupdateson Covid-192(Dic): 1–5.
Levani, Prastya, and Mawaddatunnadila. 2021. “Coronavirus Disease 2019
(Covid-19): Patogenesis, Manifestasi Klinis Dan Pilihan Terapi.” Jurnal
Kedokteran dan Kesehatan 17(1): 44–57.
https://jurnal.umj.ac.id/index.php/JKK/article/view/6340.
Mirnawati HiHamjah, Pradnya Paramita, and Tati Nuryati. 2022. “Analysis of
Adolescent Compliance Factors Implementing the Covid-19 Health Protocol
in North Ternate High School in 2021.” Jurnal Inovasi Penelitian 2(8):
2647–56. https://stp-mataram.e-journal.id.
Misnah, Agus Alim Abdullah, Mansyur Arif, and Burhanuddin Bahar. 2016.
“Pemeriksaan Prothrombin Time Dan Activated Partial Thromboplastin
Time Dengan Humaclot Va Serta Sysmex Ca 500.” Indonesian Journal of
Clinical Pathology and Medical Laboratory 18(3): 147.
Mu’afa, K, and T S N Asih. 2021. “Penyelesaian Numerik Model Dinamika Virus
Corona (SARS-CoV-2) Penyebab Covid-19 Dengan Sistem Imun Tubuh.”
PRISMA, Prosiding Seminar Nasional Matematika 4: 718–26.
https://journal.unnes.ac.id/sju/index.php/prisma/.
Rahmawaty, Desi, Nadia Muslimah Annisa, and Haryati. 2021. “Hemostatic
Factors and Its Correlation with Outcomes of Covid-19 Confirmed Patients
in Ulin Regional Hospital Banjarmasin.” ACI (Acta Cardiologia
Indonesiana) 7(2): 7.
Rusdiana, Taofik, and Rizki Akbar. 2020. “Perkembangan Terkini Terapi
Antikoagulan Pada Pasien Covid-19 Bergejala Berat.” Jurnal Sains Farmasi
& Klinis 7(3): 244.
Shi, Wei, Jiagao Lv, and Li Lin. 2020. “Since January 2020 Elsevier Has Created
a Covid-19 Resource Centre with Free Information in English and Mandarin
on the Novel Coronavirus Covid-19. The Covid-19 Resource Centre Is
Hosted on Elsevier Connect , the Company ’ s Public News and Information
.” (January).
Tal, Shir, Galia Spectre, Ran Kornowski, and Leor Perl. 2020. “Venous
Thromboembolism Complicated with Covid-19: What Do We Know so
Far?” Acta Haematologica 143(5): 417–24.
Taroeno, Suryo Aribowo, Dimas Adjie Yuda, Zaid Ziyaadatulhuda, and Anindya
Atiqah Ristanti. 2022. “Pandemi Belum Selesai: Kiat Ikhtiar Tahun Kedua
Pandemi Covid-19.” Jurnal Pengabdian Masyarakat Medika: 38–42.
Willim, Herick Alvenus, Amanda Trixie Hardigaloeh, and Alice Inda Supit. 2020.
“Koagulopati Pada Coronavirus Disease -2019 (Covid-19 ): Tinjauan
Pustaka.” Intisari Sains Medis 11(3): 749–56.
Yorike, D, MR, and Syafaat M. 2022. “Analysis of D-Dimer Level and
Prothombin Time (PT) Activated Prothombin Thromboplastin (APTT) on
Heparin Administration to Covid-19 Patients.” Indonesian Journal of
Medical Laboratory Science and Technology 4(1): 91–98.
Yunus, Muhammad. “Profil Koagulasi Pasien Covid-19Yang Mendapat Terapi
Antikoagulan Di ICU Coagulation Profile of Covid-19 Patients That
Received Anticoagulant Therapy in ICU.” 14: 1–12.
Zhou, Fei. 2020. “Clinical Course and Risk Factors for Mortality of Adult
Inpatients with Covid-19 in Wuhan, China: A Retrospective Cohort Study.”
The Lancet 395(10229): 1054–62. http://dx.doi.org/10.1016/S0140-
6736(20)30566-3.
citation:   Tuti, Sugiarti dan Iis, Afriayani dan Sri, Wahyuni Handayani  (2022) HUBUNGAN PROTROMBIN TIME, ACTIVED PARTIAL THROMBOPLASTIN TIME DAN D-dimer PADA PASIEN COVID-19 DI RSUD PASAR REBO.  Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PROF. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/41264/1/AS03-230016%20oke.pdf