eprintid: 357
rev_number: 7
eprint_status: archive
userid: 587
dir: disk0/00/00/03/57
datestamp: 2017-11-08 01:25:46
lastmod: 2017-11-08 01:25:46
status_changed: 2017-11-08 01:25:46
type: article
metadata_visibility: show
creators_name: YATI, KORI
creators_name: SRIFIANA, YUDI
creators_name: PUTRA, FARENSYAH
creators_id: koriyati@uhamka.ac.id
title: EFFECT OF OPTIMIZATION OF TWEEN 80 AND PROPYLENE GLYCOL AS A SURFACTANT AND
COSURFACTANT ON THE PHYSICAL PROPERTIES OF ASPIRIN MICROEMULSION
ispublished: pub
subjects: Q1
subjects: QD
divisions: sch_med
keywords: Aspirin, Transdermal, Microemulsions, Tween 80
abstract: Background: Aspirin is recommended as a first-line antiplatelet drug for all types of acute diseases that cause thrombosis in the blood vessel,
especially in cardiovascular disease. Orally administered aspirin has side effects such as the risk of gastrointestinal bleeding and has presystemic
metabolism in the gastrointestinal tract and liver. Transdermal delivery offers an alternative for administering aspirin that by passes the gut and this
may be more convenient and safe for long-term use. This study used a form of microemulsion to prevent hydrolysis of aspirin because it contains a
high concentration of the surfactant. A microemulsion is a dosage form that can penetrate into the skin for transdermal delivery.
Objectives: The aim of this research was to evaluate the effect of Tween 80 and propylene glycol as the surfactant and cosurfactant on the physical
stability of the microemulsion.
Materials and Methods: Various concentrations of Tween 80 and propylene glycol (2:1) were used 54%, 57%, 60%, and 63%, and the physical
stability of the different microemulsions was tested for 6 weeks.
Result: The results showed that the formula F3 was the most stable formula. The formula F3 showed the following properties such as pH of 3.74±0.30,
viscosity of 1198.76±56.02 cps, BJ of 1.0669±0.005 g/mL, surface tension of 38.77±0.43 dyne/cm, and particle size of 49.46±6.91 nm.
Conclusions: Based on the results concluded that the optimum concentration of Tween 80 as the surfactant and propylene glycol as the cosurfactant
with a ratio of 2:1 was 60%.
publisher: Innovare Academic Sciences
official_url: https://innovareacademics.in/journals/index.php/ijap/index
id_number: 10.22159/ijap.2017.v9s1.71_78
full_text_status: public
publication: International Journal of Applied Pharmaceutics
volume: 9
pagerange: 127-129
refereed: TRUE
issn: 0975–7058
related_url_url: https://innovareacademics.in/journals/index.php/ijap/article/view/23312
related_url_type: pub
referencetext: Ammar HO, Ghorab M, El-Nahhas SA, Kamel R. Design of a
transdermal delivery system for aspirin an antithrombotic drug. Int J
Pharm 2006;327(1-2):81-8.
Kogan A, Garti N. Microemulsions as transdermal drug delivery
vehicles. Adv Colloid Interface Sci 2006;123-126:369-85.
Khar RK, Vyas SP, Ahmad FJ, Jain GK. Lachman/Lieberman’s
the Theory and Practice of Industrial Pharmacy. 4th ed. India: CBS
Publishers and Distribution; 2013.
Department of Health. Farmakope Indonesia IV. Jakarta: Department of
Health; 1995.
Noerono S. Buku Pelajaran Teknologi Farmasi. Yogyakarta: Universitas
Gajah Mada Press; 1994.
Rowe RC, Paul JS, Quinn ME. Handbook of Pharmaceutical Excipient.
th ed. Washington, DC, Grayslake: Pharmaceutical Press and American
Pharmacists Association; 2009.
citation:   YATI, KORI dan SRIFIANA, YUDI dan PUTRA, FARENSYAH   EFFECT OF OPTIMIZATION OF TWEEN 80 AND PROPYLENE GLYCOL AS A SURFACTANT AND COSURFACTANT ON THE PHYSICAL PROPERTIES OF ASPIRIN MICROEMULSION.  International Journal of Applied Pharmaceutics, 9.  pp. 127-129.  ISSN 0975–7058     
document_url: http://repository.uhamka.ac.id/id/eprint/357/1/IJAP%202017-ICAPPS%202016.pdf