<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "SIMULTANEOUS ANALYTICAL METHOD DEVELOPMENT OF 6-MERCAPTO¬PURINE AND 6-METHYLMERCAPTOPURINE IN PLASMA BY HIGH PERFOR¬MANCE LIQUID CHROMATOGRAPHY-PHOTODIODE ARRAY"^^ . "Objective: 6-Mercaptopurin is antineoplastic drug that is included in antimetabolite\r\ngroup and is used in acute lymphoblastic leukemia medication. 6-Mercaptopurin\r\nis inactive pro-drug that will be metabolized into metabolites. One\r\nof its metabolites is 6-methylmercaptopurine. This study is aimed to optimize\r\nthe analytical conditions and perform validation for the analysis of 6-mercaptopurine\r\nand 6-methylmercaptopurine in plasma. Method: Separation was performed\r\nusing Waters 2996 HPLC, C18 SunfireTM column (5μm, 250 x 4.6 mm)\r\nwith the mobile phase containing water-methanol-acetonitrile with gradient\r\nelution, and detected at 303 nm. 5-Fluorouracil was used as internal standard.\r\nPlasma extraction was done by liquid-liquid extraction using dichloromethane.\r\nResult: The method was linear at concentration range of 2.0 – 200.0 ng/mL\r\nwith r > 0.9991 for 6-mercaptopurine and 20 – 2000 ng/mL with r > 0.9993 for\r\n6-methylmercaptopurine. Accuracy and precision within-run and between-run\r\nfulfill the acceptance criteria with % RE and relative standard deviation (%\r\nRSD) ≤ 20% (LLOQ) and ≤ 15% (QC samples). 6-Mercaptopurine and 6-methylmercaptopurine\r\nwas stable in plasma at least for 21 days when stored at -20ºC.\r\nConclusion: The bio-analytical method was sensitive, selective and all the parameters\r\nfulfilled the acceptance criteria of the EMA Bio-analytical Method\r\nValidation Guideline, 2011."^^ . "2017" . . "9" . "1" . . "Journal of Young Pharmacists"^^ . . . "09751483" . . . . . . . . . . . . . . . . "Yahdiana"^^ . "Yahdiana Harahap"^^ . "Yahdiana Yahdiana Harahap"^^ . . "Rizka"^^ . "Rizka Andalusia"^^ . "Rizka Rizka Andalusia"^^ . . "Nurul"^^ . "Nurul Azizah"^^ . "Nurul Nurul Azizah"^^ . . "Supandi"^^ . "Supandi"^^ . "Supandi Supandi"^^ . . "Department of Pharmacy, Faculty of Pharmacy and Science, UHAMKA, Jakarta, Indonesia"^^ . . . "Faculty of Pharmacy Universitas Indonesia, Depok, INDONESIA."^^ . . . . . . . "SIMULTANEOUS ANALYTICAL METHOD DEVELOPMENT OF 6-MERCAPTO¬PURINE AND 6-METHYLMERCAPTOPURINE IN PLASMA BY HIGH PERFOR¬MANCE LIQUID CHROMATOGRAPHY-PHOTODIODE ARRAY (Text)"^^ . . . "jurnal Young Pharm.pdf"^^ . . . "SIMULTANEOUS ANALYTICAL METHOD DEVELOPMENT OF 6-MERCAPTO¬PURINE AND 6-METHYLMERCAPTOPURINE IN PLASMA BY HIGH PERFOR¬MANCE LIQUID CHROMATOGRAPHY-PHOTODIODE ARRAY (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "SIMULTANEOUS ANALYTICAL METHOD DEVELOPMENT OF 6-MERCAPTO¬PURINE AND 6-METHYLMERCAPTOPURINE IN PLASMA BY HIGH PERFOR¬MANCE LIQUID CHROMATOGRAPHY-PHOTODIODE ARRAY (Other)"^^ . . . . . . "preview.jpg"^^ . . . "SIMULTANEOUS ANALYTICAL METHOD DEVELOPMENT OF 6-MERCAPTO¬PURINE AND 6-METHYLMERCAPTOPURINE IN PLASMA BY HIGH PERFOR¬MANCE LIQUID CHROMATOGRAPHY-PHOTODIODE ARRAY (Other)"^^ . . . . . . "medium.jpg"^^ . . . "SIMULTANEOUS ANALYTICAL METHOD DEVELOPMENT OF 6-MERCAPTO¬PURINE AND 6-METHYLMERCAPTOPURINE IN PLASMA BY HIGH PERFOR¬MANCE LIQUID CHROMATOGRAPHY-PHOTODIODE ARRAY (Other)"^^ . . . . . . "small.jpg"^^ . . . "SIMULTANEOUS ANALYTICAL METHOD DEVELOPMENT OF 6-MERCAPTO¬PURINE AND 6-METHYLMERCAPTOPURINE IN PLASMA BY HIGH PERFOR¬MANCE LIQUID CHROMATOGRAPHY-PHOTODIODE ARRAY (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #348 \n\nSIMULTANEOUS ANALYTICAL METHOD DEVELOPMENT OF 6-MERCAPTO¬PURINE AND 6-METHYLMERCAPTOPURINE IN PLASMA BY HIGH PERFOR¬MANCE LIQUID CHROMATOGRAPHY-PHOTODIODE ARRAY\n\n" . "text/html" . . . "RS Pharmacy and materia medica"@en . .