<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Evaluation of the potential of Stichopus Herrmanni extract in inhibiting cervical cancer cell proliferation"^^ . "Background: Sea cucumbers, particularly Stichopus herrmanni, are known for their medicinal value in Asian\r\ntraditional medicine owing to the abundant presence of saponins, terpenoids, and phenols. Investigations on\r\nthese bioactive compounds have revealed their cytotoxic propensity against various cancer cell lines, indicating\r\n\r\ntheir therapeutic potential. However, limited research exists on the potential application of sea cucumber ex-\r\ntracts specifically in cervical cancer.\r\n\r\nPurpose: This study aimed to identify the bioactive components of Stichopus herrmanni extract, determine their\r\nassociation with potential targets in cervical cancer, and evaluate their cytotoxic effects on cervical cancer cells.\r\nStudy Design: This experimental study employed both in vitro and in silico methods to evaluate the potential\r\ncytotoxic effects of Stichopus herrmanni extracts on cervical cancer cells.\r\nMethods: Liquid Chromatography-Mass Spectrometry (LC-MS) was used to identify and quantify the bioactive\r\n\r\nconstituents of Stichopus herrmanni crude extract. An in silico approach was used to identify the active compo-\r\nnents, potential targets, and signaling pathways of the extract. Furthermore, the MTT assay was used to deter-\r\nmine the cytotoxicity of the extract.\r\n\r\nResults: LC-MS analysis identified the presence of rengyol, eucommiol, ganoderic acid, and 6-isoinosine in the\r\nextracts. An in silico study based on structural analysis identified ganoderic acid and isoinosine as crucial active\r\ncomponents capable of regulating majority of the targets associated with cervical cancer. Overlapping targets,\r\nnamely, CASP3, CAT, FASLG, IL24, TP53, TP53BP1, ALB, BDNF, and COX2 between cervical cancer and the\r\nextract highlighted new therapeutic prospects for cervical cancer following protein-protein interaction network\r\nscreening. The in vitro cytotoxic effects of the extracts were established in HeLa cells.\r\nConclusion: Research indicates that Stichopus herrmanni may be a valuable source of bioactive compounds with\r\npotential applications in the treatment of cancer and the induction of apoptosis"^^ . "2024-08" . . "4" . "100557" . . "Elsevier"^^ . . . "Phytomedicine Plus"^^ . . . "26670313" . . . . . . . . . . . . . . . . "bety semara"^^ . "lakshmi"^^ . "bety semara lakshmi"^^ . . "Irena"^^ . "Ujianti"^^ . "Irena Ujianti"^^ . . "wawang s"^^ . "sukarya"^^ . "wawang s sukarya"^^ . . "Zahra"^^ . "Nurusshofa"^^ . "Zahra Nurusshofa"^^ . . . . . . "Evaluation of the potential of Stichopus Herrmanni extract in inhibiting cervical cancer cell proliferation (Text)"^^ . . . . . "ScopusQ2_elsevier_sticopus and cervical cancer.pdf"^^ . . . "Evaluation of the potential of Stichopus Herrmanni extract in inhibiting cervical cancer cell proliferation (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Evaluation of the potential of Stichopus Herrmanni extract in inhibiting cervical cancer cell proliferation (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Evaluation of the potential of Stichopus Herrmanni extract in inhibiting cervical cancer cell proliferation (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Evaluation of the potential of Stichopus Herrmanni extract in inhibiting cervical cancer cell proliferation (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #34681 \n\nEvaluation of the potential of Stichopus Herrmanni extract in inhibiting cervical cancer cell proliferation\n\n" . "text/html" . . . "R Medicine (General)"@en . .