<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "ANALYSIS OF 6-MERCAPTOPURINE AND 6-METHYLMERCAPTOPURINE IN DRIED BLOOD\r\nSPOTS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS\r\nAPPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS"^^ . "Objective: To analyze and validate 6-mercaptopurine (6-MP) and 6-methylmercaptopurine (6-MMP) in dried blood spots (DBS) using liquid\r\nchromatography-tandem mass spectrometry (LC/MS-MS).\r\nMethods: Bio-sampling dried blood spot with DBS-CAMAG® paper diameter of 8 mm and extracted with acetonitrile-methanol (1:3) containing\r\ninternal standard 5-fluorouracil (5-FU). Separation was performed with C18 column Acquity® 1.7 μm (2.1 mm × 100 mm), with a mobile phase mixture\r\nof 0.1% formic acid in water 0.1% formic acid in acetonitrile with gradient elution and flow rate 0.2 ml/min. Mass detection was Waters Xevo TQD\r\nwith positive electrospray ionization (ESI) for 6-MP, 6-MMP and negative ESI for 5-FU in multiple reaction monitoring modes. The ions of 6-MP was\r\ndetected at m/z 153.09->119.09, 6-MMP at m/z 167.17->126.03, and 5-FU at m/z 129.15->42.05.\r\nResults: This method fulfill the requirements of selectivity, linearity, lower limit of quantification, accuracy, precision, carry-over, matrix effects,\r\nand stability which refers to the european medicines agency (EMEA) guidelines. The linearity of 0.99 was 26-1000 ng/mL for 6-MP and 6-MMP,\r\nrespectively. The validated method was applied to two childhood ALL maintenance phase. Retrieved 6-MP levels of 10.37 pmol/8×108 erythrocytes,\r\nrespectively. The levels of 6-MMP gained 16.59 pmol/8×108 erythrocytes, respectively.\r\nConclusion: The developed LC/MS-MS method is valid to analysis 6-MP and 6-MMP in DBS simultaneous in vitro according to EMEA guidelines. The\r\nmethod was successfully applied to authentic capillary blood samples from two childhood patients with ALL in the maintenance phase.\r\nKeywords: 6-mercaptopurine, 6-methylmercaptopurine, Dried blood spots, Acute lymphoblastic leukemia."^^ . "2017" . . "10" . "9" . . "Asian Journal of Pharmaceutical and Clinical Research"^^ . . . "09742441" . . . . . . . . . . . . . . . . . . . "Rizka"^^ . "Rizka Andalusia"^^ . "Rizka Rizka Andalusia"^^ . . "Yahdiana"^^ . "Yahdiana Harahap"^^ . "Yahdiana Yahdiana Harahap"^^ . . "Supandi"^^ . "Supandi"^^ . "Supandi Supandi"^^ . . "Harmita"^^ . "Harmita"^^ . "Harmita Harmita"^^ . . "Marlina"^^ . "Marlina Ika"^^ . "Marlina Marlina Ika"^^ . . "Department of Pharmacy, Faculty of Pharmacy and Science, UHAMKA, Jakarta, Indonesia"^^ . . . . . . . "ANALYSIS OF 6-MERCAPTOPURINE AND 6-METHYLMERCAPTOPURINE IN DRIED BLOOD\r\nSPOTS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS\r\nAPPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS (Text)"^^ . . . "AJPCR.pdf"^^ . . . "ANALYSIS OF 6-MERCAPTOPURINE AND 6-METHYLMERCAPTOPURINE IN DRIED BLOOD\r\nSPOTS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS\r\nAPPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "ANALYSIS OF 6-MERCAPTOPURINE AND 6-METHYLMERCAPTOPURINE IN DRIED BLOOD\r\nSPOTS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS\r\nAPPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS (Other)"^^ . . . . . . "preview.jpg"^^ . . . "ANALYSIS OF 6-MERCAPTOPURINE AND 6-METHYLMERCAPTOPURINE IN DRIED BLOOD\r\nSPOTS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS\r\nAPPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS (Other)"^^ . . . . . . "medium.jpg"^^ . . . "ANALYSIS OF 6-MERCAPTOPURINE AND 6-METHYLMERCAPTOPURINE IN DRIED BLOOD\r\nSPOTS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS\r\nAPPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS (Other)"^^ . . . . . . "small.jpg"^^ . . . "ANALYSIS OF 6-MERCAPTOPURINE AND 6-METHYLMERCAPTOPURINE IN DRIED BLOOD\r\nSPOTS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS\r\nAPPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #346 \n\nANALYSIS OF 6-MERCAPTOPURINE AND 6-METHYLMERCAPTOPURINE IN DRIED BLOOD \nSPOTS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS \nAPPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS\n\n" . "text/html" . . . "RS Pharmacy and materia medica"@en . .