eprintid: 33739
rev_number: 9
eprint_status: archive
userid: 1660
dir: disk0/00/03/37/39
datestamp: 2024-03-08 11:01:44
lastmod: 2024-03-08 11:01:44
status_changed: 2024-03-08 11:01:44
type: article
metadata_visibility: show
creators_name: Siska, Siska
creators_id: siska@uhamka.ac.id
title: Anti-obesity Potency of Chili Extract in Male White Rat
ispublished: pub
subjects: Q1
divisions: 48901
abstract: Obesity is a global epidemic for non-communicable diseases characterized by a body mass index more 
than 30 kg/m2
. Epidemiological data show that consuming foods containing capsaicin, the main active 
compound and causes a spicy taste in chili associated with a decrease in the prevalence of obesity. This 
study aims to determine the effect of consumption chili on lipid profile of rats fed high-fat diet and their 
potential as anti-obesity. Treatment was conducted on 24 male Sprague-Dawley rats and divided into 
6 groups namely the regular group (N) was given a standard diet and the group that was given a high�fat diet (PTL) and varied with a dose of 0.5 g/kg BW. Every 14 days of treatment, the weight of the 
rats was weighed, and blood was taken retro-orbital to obtain the serum. The rat serum was tested for 
total cholesterol (TC), triglycerides, LDL, and HDL through the colorimetric method. The levels were 
assessed using a clinical spectrophotometer. The results showed a decrease in weight, LDL, increase 
HDL (p<0.05), decrease in TC, triglyceride (p>0.05). This showed chili extract has the potential as an 
anti-obesity with parameters of measuring lipid profile and weight but needs dose adjuster and timing 
of extract administration
full_text_status: public
publication: Indonesian Journal of Pharmaceutical Science and Technology
refereed: TRUE
citation:   Siska, Siska   Anti-obesity Potency of Chili Extract in Male White Rat.  Indonesian Journal of Pharmaceutical Science and Technology.       
document_url: http://repository.uhamka.ac.id/id/eprint/33739/1/Artikel%20Antiobesitas.pdf