eprintid: 33295
rev_number: 8
eprint_status: archive
userid: 1558
dir: disk0/00/03/32/95
datestamp: 2024-02-17 06:23:20
lastmod: 2024-02-17 06:23:20
status_changed: 2024-02-17 06:23:20
type: article
succeeds: 26726
metadata_visibility: show
creators_name: Siska, Siska
creators_id: siska@uhamka.ac.id
contributors_type: http://www.loc.gov/loc.terms/relators/AUT
title: Effect of the ethanol extract of Pereskia bleo (Kunth) 
DC. on the blood pressure and electrolyte levels of 
hypertensive rats
ispublished: pub
subjects: Q1
divisions: 48901
abstract: Introduction: The green cactus Pereskia bleo is thought to have anti-cancer, anti-tumor, anti�inflammatory, and anti-rheumatic properties. Additionally, it treats hypertension and diabetes; 
However, no scientific evaluation of its antihypertensive activity has been conducted. The 
purpose of this study was to investigate the effects of oral administration of P. bleo extract (PBE) 
on male rats’ blood pressure, urine volume, and sodium and potassium levels.
Methods: Sodium chloride (NaCl) solution (4%) was administered orally to induce hypertension. 
A non-invasive tail method was used to measure blood pressure. The sodium and potassium 
concentrations as well as the total volume of urine were measured from the collected urine.
Results: Hypertensive rats’ blood pressure was reduced by 250, 500, and 1000 mg/kg of PBE. 
Similar to the positive control group (captopril dose of 1.25 mg/kg BW), the most significant 
drop in blood pressure was occurred at the dose of 1000 mg/kg BW (P>0.05). All treatment 
groups saw an increase in urinary sodium and potassium levels.
Conclusion: In NaCl-induced hypertensive rats, oral administration of P. bleo ethanolic extract 
decreased blood pressure to the standard value by increasing urinary sodium and potassium 
levels. Hence, it might be used as an anti-hypertensive agent.
date: 2023-07
date_type: published
publisher: Shahrekord University of Medical Sciences, Shahrekord, Iran.
official_url: http://herbmedpharmacol.com/
full_text_status: public
publication: Effect of the ethanol extract of Pereskia bleo (Kunth)  DC. on the blood pressure and electrolyte levels of  hypertensive rats
volume: 12
number: 3
pagerange: 448-452
refereed: TRUE
issn: 2345-5004
citation:   Siska, Siska  (2023) Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats.  Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats, 12 (3).  pp. 448-452.  ISSN 2345-5004     
document_url: http://repository.uhamka.ac.id/id/eprint/33295/2/jhp-12-448.pdf
document_url: http://repository.uhamka.ac.id/id/eprint/33295/7/Artikel%20HerMed.pdf