%0 Journal Article
%@ 2345-5004
%A Siska, Siska
%D 2023
%F repository:33295
%I Shahrekord University of Medical Sciences, Shahrekord, Iran.
%J Effect of the ethanol extract of Pereskia bleo (Kunth)  DC. on the blood pressure and electrolyte levels of  hypertensive rats
%N 3
%P 448-452
%T Effect of the ethanol extract of Pereskia bleo (Kunth)   DC. on the blood pressure and electrolyte levels of   hypertensive rats
%U http://repository.uhamka.ac.id/id/eprint/33295/
%V 12
%X Introduction: The green cactus Pereskia bleo is thought to have anti-cancer, anti-tumor, anti�inflammatory, and anti-rheumatic properties. Additionally, it treats hypertension and diabetes;   However, no scientific evaluation of its antihypertensive activity has been conducted. The   purpose of this study was to investigate the effects of oral administration of P. bleo extract (PBE)   on male rats’ blood pressure, urine volume, and sodium and potassium levels.  Methods: Sodium chloride (NaCl) solution (4%) was administered orally to induce hypertension.   A non-invasive tail method was used to measure blood pressure. The sodium and potassium   concentrations as well as the total volume of urine were measured from the collected urine.  Results: Hypertensive rats’ blood pressure was reduced by 250, 500, and 1000 mg/kg of PBE.   Similar to the positive control group (captopril dose of 1.25 mg/kg BW), the most significant   drop in blood pressure was occurred at the dose of 1000 mg/kg BW (P>0.05). All treatment   groups saw an increase in urinary sodium and potassium levels.  Conclusion: In NaCl-induced hypertensive rats, oral administration of P. bleo ethanolic extract   decreased blood pressure to the standard value by increasing urinary sodium and potassium   levels. Hence, it might be used as an anti-hypertensive agent.