<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Acute oral toxicity of sunda porcupine’s (Hystrix javanica, F.\r\nCuvier 1823) quills crude extract on male sprague Dawley\r\nrats using fixed dose method"^^ . "Sunda porcupine (Hystrix javanica F. Cuvier 1823) is an endemic mammalian fauna from Indonesia known as\r\na pest since they damage crops like corn and tubers. Local people hunt the porcupine to decrease the damage, but others\r\nhunt for its medicinal benefits. They believe that sunda porcupine has medicinal benefits, yet this ethnomedicine has not\r\nbeen recorded well and has no sufficient scientific report. One of the interesting ethnomedicines is that local people\r\nbelieve the quills of sunda porcupine can treat toothache. Our research aims to add a scientific record of the sunda\r\nporcupine’s quills as well the acute toxicity effect of sunda porcupine’s quills crude extract on male Sprague Dawley rats.\r\nThe extraction of the active compound of the quills was using ethanol 70%. The determination of acute toxicity effect\r\nwas using a fixed dose method by oral administration, including two steps: sighting study and main study, with four\r\ndoses: 5 mg/kg; 50 mg/kg; 300 mg/kg; and 2.000 mg/kg. We also observed the histological effect on liver and kidney\r\ntissues. The result showed that the oral administration of the sunda porcupine’s quills crude extract by the method of the\r\nfixed dose does not cause death in all rats used both after 24 hours (acute effect) and 14 days (delayed effect). Based on\r\nthe fixed dose method, we can categorize the sunda porcupine’s quills crude extract as non-toxic. Although the rats were\r\nclinically healthy and showed no symptoms of intoxication during 14 days of observation, histopathological analysis of\r\nthe liver and kidney showed lesions which cannot be ignored. Histopathological analysis showed that the higher the dose,\r\nthe lesions tended to increase the severity on the liver and kidney, but the active substance administered did not kill the\r\nrats and the severity was mostly mild. It is in line with the percentage of body weight gain, which is a group of placebo >\r\n300 mg/kg > 2000 mg/kg, which may occur because the body prioritizes repairing the damage of the tissues due to the\r\nexact administration rather than for growth. These findings can be used as consideration for further toxicity study on\r\nsunda porcupine’s quills crude extract, such as chronic and subchronic toxicity tests, both to ensure the safety and to\r\ncomplete the toxicity study of the extract."^^ . . . "AIP Conf. Proc. 2972"^^ . . . . . . . . "Muhamad Arif"^^ . "Budiman"^^ . "Muhamad Arif Budiman"^^ . . . . . . "Acute oral toxicity of sunda porcupine’s (Hystrix javanica, F.\r\nCuvier 1823) quills crude extract on male sprague Dawley\r\nrats using fixed dose method (Archive)"^^ . . . "080004_1_5.0183764.pdf"^^ . . . "Acute oral toxicity of sunda porcupine’s (Hystrix javanica, F.\r\nCuvier 1823) quills crude extract on male sprague Dawley\r\nrats using fixed dose method (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Acute oral toxicity of sunda porcupine’s (Hystrix javanica, F.\r\nCuvier 1823) quills crude extract on male sprague Dawley\r\nrats using fixed dose method (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Acute oral toxicity of sunda porcupine’s (Hystrix javanica, F.\r\nCuvier 1823) quills crude extract on male sprague Dawley\r\nrats using fixed dose method (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Acute oral toxicity of sunda porcupine’s (Hystrix javanica, F.\r\nCuvier 1823) quills crude extract on male sprague Dawley\r\nrats using fixed dose method (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #30845 \n\nAcute oral toxicity of sunda porcupine’s (Hystrix javanica, F. \nCuvier 1823) quills crude extract on male sprague Dawley \nrats using fixed dose method\n\n" . "text/html" . . . "QD Chemistry"@en . . . "QL Zoology"@en . . . "R Medicine (General)"@en . .