<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Effects of Nanocurcumin Against Cisplatin\r\nInduced-Nephrotoxicity in Rats"^^ . "Nephrotoxicity is the major limitation for the clinical use of cisplatin as an antitumor. Nanocurcumin, unlike\r\ncurcumin, is readily dispersed in aqueous media. The purpose of this preliminary study was to investigate\r\nthe potential of nanocurcumin against cisplatin-induced nephrotoxicity in rats. This study conducted for 9 days\r\ntreatment, five groups of male Sprague-Dawley rats were examined: normal, cisplatin (CDDP) 7 mg/kgBW,\r\nCDDP+curcumin (CMN) 100 mg/kg BW/day, CDDP+nanocurcumin (NC) 50 mg/kg BW/day, and CDDP+NC\r\n100 mg/kg BW/day. After 72 h following injection cisplatin, specimens were collected. Plasma blood urea nitrogen\r\n(BUN), plasma creatinine, urinary ureum levels, urinary creatinine levels, MDA levels in kidney, and GSH levels in\r\nkidney were investigated. Rats were weighed before and after study. Data were analyzed using one-way analysis\r\nof variance (ANOVA). This study resulted a single dose injection of cisplatin caused a significant increase in\r\nplasma BUN, plasma creatinine, and MDA levels by 6 fold, 2.4 fold, and 1.4 fold respectively as compared to\r\nnormal group. Pre-treatment with CMN and NC were reduced plasma BUN levels, plasma creatinine levels, MDA\r\nlevels in kidney and increased GSH level in kidney compared with CDPP-induced nephrotoxicity rats without\r\ntreatment. At the end of treatment, the difference of body weight between normal group and CDDP group was\r\nstatistically significant. CDPP is able to induce nephrotoxicity in rats that mimicked acute kidney injury in human.\r\nCMN and NC tend to reduce the CDPP-induced nephrotoxiciy."^^ . . . "Advanced Science Letter"^^ . . . . . . . . . "Shinta"^^ . "Shinta Dewi Permata Sari"^^ . "Shinta Shinta Dewi Permata Sari"^^ . . . . . . "Effects of Nanocurcumin Against Cisplatin\r\nInduced-Nephrotoxicity in Rats (Text)"^^ . . . "Effects of Nanocurcumin Against Cisplatin Induced Nephrotoxicity in Rats.pdf"^^ . . . "Effects of Nanocurcumin Against Cisplatin\r\nInduced-Nephrotoxicity in Rats (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Effects of Nanocurcumin Against Cisplatin\r\nInduced-Nephrotoxicity in Rats (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Effects of Nanocurcumin Against Cisplatin\r\nInduced-Nephrotoxicity in Rats (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Effects of Nanocurcumin Against Cisplatin\r\nInduced-Nephrotoxicity in Rats (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Effects of Nanocurcumin Against Cisplatin\r\nInduced-Nephrotoxicity in Rats (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #2663 \n\nEffects of Nanocurcumin Against Cisplatin \nInduced-Nephrotoxicity in Rats\n\n" . "text/html" . . . "E151 United States (General)"@en . .