eprintid: 23451
rev_number: 7
eprint_status: archive
userid: 1566
dir: disk0/00/02/34/51
datestamp: 2023-04-13 09:05:22
lastmod: 2023-04-13 09:05:22
status_changed: 2023-04-13 09:05:22
type: book
metadata_visibility: show
creators_name: Inding, Gusmayadi
creators_name: Ani Pahriyani, Ani
creators_name: Onny, Indriani
creators_id: indinggusmayadi@uhamka.ac.id
creators_id: anipahriyani@uhamka.ac.id
creators_orcid: 0000-0003-4756-8376
title: EFFECT OF INCREASING HPMC CONCENTRATION ON PARTICULATE
DISSOLUTION OF SOLID DISPERSION SYSTEM KETOPROFEN-HPMC
ispublished: pub
subjects: D1
abstract: Ketoprofen is one of practically water insoluble drug compounds, the factor causing
dissolution and bioavailability the drugs is very low. To dissolve this problem, a
research was conducted by making solid dispersion system of ketoprofen using HPMC
as hydrophilic polymer. The ketoprofen solid dispersion was made in 5 combination i.e.
0%, 5%, 10%, 15%, and 20% of HPMC. Method of production of solid dispersion using
dissolving method, with ethanol 70% as solvent. The solid dispersions were
characterized for its crystal using thermal analyses by DSC (Differential Scanning
Calorimetry), and followed for dissolution using paddle-type method in HCl pH 1.2
buffer as medium. The results showed that increasing of HPMC increased ED
60
 of
ketoprofen, whiles the maximum value at 10% HPMC concentration with ED
60
 40.42%.
By one-way ANOVA analyses with 95% of significance level, among all combinations
showed a significant differences. On the other hand, thermal analyses results showed
that increasing of HPMC gave a slight decreasing melting point on solid dispersion
system ketoprofen-HPMC below pure ketoprofen. It could be concluded that HPMC is
less effective when used as a hydrophilic combination in solid dispersion.
date: 2015-01-10
publisher: FFS UHAMKA
full_text_status: public
pages: 182
refereed: TRUE
isbn: 978-602-71959-0-5
citation:   Inding, Gusmayadi dan Ani Pahriyani, Ani dan Onny, Indriani  (2015) EFFECT OF INCREASING HPMC CONCENTRATION ON PARTICULATE DISSOLUTION OF SOLID DISPERSION SYSTEM KETOPROFEN-HPMC.    FFS UHAMKA.  ISBN 978-602-71959-0-5     
document_url: http://repository.uhamka.ac.id/id/eprint/23451/1/PROCEEDING%20Chalenges-ISBN%20978-602-71959-0-5.pdf