TY  - BOOK
EP  - 182
N2  - Ketoprofen is one of practically water insoluble drug compounds, the factor causing
dissolution and bioavailability the drugs is very low. To dissolve this problem, a
research was conducted by making solid dispersion system of ketoprofen using HPMC
as hydrophilic polymer. The ketoprofen solid dispersion was made in 5 combination i.e.
0%, 5%, 10%, 15%, and 20% of HPMC. Method of production of solid dispersion using
dissolving method, with ethanol 70% as solvent. The solid dispersions were
characterized for its crystal using thermal analyses by DSC (Differential Scanning
Calorimetry), and followed for dissolution using paddle-type method in HCl pH 1.2
buffer as medium. The results showed that increasing of HPMC increased ED
60
 of
ketoprofen, whiles the maximum value at 10% HPMC concentration with ED
60
 40.42%.
By one-way ANOVA analyses with 95% of significance level, among all combinations
showed a significant differences. On the other hand, thermal analyses results showed
that increasing of HPMC gave a slight decreasing melting point on solid dispersion
system ketoprofen-HPMC below pure ketoprofen. It could be concluded that HPMC is
less effective when used as a hydrophilic combination in solid dispersion.
A1  - Inding, Gusmayadi
A1  - Ani Pahriyani, Ani
A1  - Onny, Indriani
TI  - EFFECT OF INCREASING HPMC CONCENTRATION ON PARTICULATE
DISSOLUTION OF SOLID DISPERSION SYSTEM KETOPROFEN-HPMC
PB  - FFS UHAMKA
UR  - http://repository.uhamka.ac.id/id/eprint/23451/
ID  - repository23451
Y1  - 2015/01/10/
SN  - 978-602-71959-0-5
AV  - public
ER  -