%0 Book
%A Inding, Gusmayadi
%A Ani Pahriyani, Ani
%A Onny, Indriani
%D 2015
%F repository:23451
%I FFS UHAMKA
%P 182
%T EFFECT OF INCREASING HPMC CONCENTRATION ON PARTICULATE  DISSOLUTION OF SOLID DISPERSION SYSTEM KETOPROFEN-HPMC
%U http://repository.uhamka.ac.id/id/eprint/23451/
%X Ketoprofen is one of practically water insoluble drug compounds, the factor causing  dissolution and bioavailability the drugs is very low. To dissolve this problem, a  research was conducted by making solid dispersion system of ketoprofen using HPMC  as hydrophilic polymer. The ketoprofen solid dispersion was made in 5 combination i.e.  0%, 5%, 10%, 15%, and 20% of HPMC. Method of production of solid dispersion using  dissolving method, with ethanol 70% as solvent. The solid dispersions were  characterized for its crystal using thermal analyses by DSC (Differential Scanning  Calorimetry), and followed for dissolution using paddle-type method in HCl pH 1.2  buffer as medium. The results showed that increasing of HPMC increased ED  60   of  ketoprofen, whiles the maximum value at 10% HPMC concentration with ED  60   40.42%.  By one-way ANOVA analyses with 95% of significance level, among all combinations  showed a significant differences. On the other hand, thermal analyses results showed  that increasing of HPMC gave a slight decreasing melting point on solid dispersion  system ketoprofen-HPMC below pure ketoprofen. It could be concluded that HPMC is  less effective when used as a hydrophilic combination in solid dispersion.