@book{repository23451,
            year = {2015},
           title = {EFFECT OF INCREASING HPMC CONCENTRATION ON PARTICULATE
DISSOLUTION OF SOLID DISPERSION SYSTEM KETOPROFEN-HPMC},
       publisher = {FFS UHAMKA},
           month = {January},
          author = {Inding, Gusmayadi and Ani Pahriyani, Ani and Onny, Indriani},
            isbn = {978-602-71959-0-5},
        abstract = {Ketoprofen is one of practically water insoluble drug compounds, the factor causing
dissolution and bioavailability the drugs is very low. To dissolve this problem, a
research was conducted by making solid dispersion system of ketoprofen using HPMC
as hydrophilic polymer. The ketoprofen solid dispersion was made in 5 combination i.e.
0\%, 5\%, 10\%, 15\%, and 20\% of HPMC. Method of production of solid dispersion using
dissolving method, with ethanol 70\% as solvent. The solid dispersions were
characterized for its crystal using thermal analyses by DSC (Differential Scanning
Calorimetry), and followed for dissolution using paddle-type method in HCl pH 1.2
buffer as medium. The results showed that increasing of HPMC increased ED
60
 of
ketoprofen, whiles the maximum value at 10\% HPMC concentration with ED
60
 40.42\%.
By one-way ANOVA analyses with 95\% of significance level, among all combinations
showed a significant differences. On the other hand, thermal analyses results showed
that increasing of HPMC gave a slight decreasing melting point on solid dispersion
system ketoprofen-HPMC below pure ketoprofen. It could be concluded that HPMC is
less effective when used as a hydrophilic combination in solid dispersion.},
             url = {http://repository.uhamka.ac.id/id/eprint/23451/}
}