eprintid: 22299
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/22/99
datestamp: 2023-04-02 12:16:25
lastmod: 2023-04-02 12:16:25
status_changed: 2023-04-02 12:16:25
type: thesis
metadata_visibility: show
creators_name: KOMALA FITRI, RAHAYU
creators_name: Nursal, Fith Khaira
title: PENGARUH VARIASI NILAI HLB SURFAKTAN NON-IONIK TWEEN
60 DAN SPAN 60 TERHADAP PELEPASAN GLUKOSAMIN
HIDROKLORIDA DALAM SISTEM NIOSOM
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Niosom merupakan salah satu teknologi sistem penghantaran transdermal yang
terususun dari kolesterol dan surfaktan non-ionik. Peranan surfakatan non-ionik
dapat ditentukan berdasarkan nilai HLB sehingga perlu dilakukan kombinasi
surfaktan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh nilai HLB
kombinasi surfaktan non-ionik Tween 60 dan Span 60 terhadap karakteristik serta
pelepasan glukosamin HCl dalam sistem niosom. Pembuatan niosom dirancang
dalam 4 formula dengan masing-masing nilai HLB kombinasi 4,7 (F1); 6,1(F2);
6,7(F3), dan 8,1 (F4). Niosom dibuat dengan metode hidrasi lapis tipis
menggunakan vacuum rotary evaporator dengan suhu 60ᵒC. Evaluasi terhadap
niosom meliputi organoleptis, pH, Bobot Jenis, Ukuran Partikel, Zeta Potensial,
Indeks Polidispersitas, Efisiensi Penjerapan dan Uji Pelepasan menggunakan
kantong dialisis. Hasil organoleptis menunjukan hasil yang sama pada seluruh
formula yakni tidak berbau, berwarna putih susu dan berbentuk cairan. Hasil
pengujian pH berada pada pH 7 dan bobot jenis diatas 1g/mL pada seluruh
formula. Ukuran partikel 422,5nm ± hingga 492,3nm±; zeta potensial -41,19 mV
± hingga -61,12 mV±; dan indeks polidispersitas <0,5 pada seluruh formula. Hasil
efisiensi penjerapan sebesar 57,22% ± 0,917 (F1); 62,13% ± 1,079 (F2); 65,85% ±
0,967 (F3); 69,57% ± 0,995 (F4). Peningkatan nilai HLB mempercepat pelepasan
glukosamin HCl dari sistem niosom setelah 120 menit pengujian. Hasil terbaik
ditunjukan oleh F4 dengan nilai efisiensi penjerapan 69,57% dan pelepasan
sebesar 92,17%. Nilai HLB kombinasi mempengaruhi karakteristik dan pelepasan
glukosamin HCl dalam sistem niosom.
Kata Kunci : Niosom, Glukosamin HCl, Surfaktan Non-Ionik, HLB, Pelepasan.
date: 2022
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   KOMALA FITRI, RAHAYU dan Nursal, Fith Khaira  (2022) PENGARUH VARIASI NILAI HLB SURFAKTAN NON-IONIK TWEEN 60 DAN SPAN 60 TERHADAP PELEPASAN GLUKOSAMIN HIDROKLORIDA DALAM SISTEM NIOSOM.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/22299/1/FS03-220521.pdf