eprintid: 22291
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/22/91
datestamp: 2023-04-02 12:16:21
lastmod: 2023-04-02 12:16:21
status_changed: 2023-04-02 12:16:21
type: thesis
metadata_visibility: show
creators_name: AULIA, NURSYIDA
creators_name: Nining, Nining
creators_name: Amalia, Anisa
title: PENGARUH NILAI HLB KOMBINASI TWEEN 60 DAN SPAN 60
SEBAGAI SURFAKTAN TERHADAP STABILITAS FISIK NIOSOM
GLUKOSAMIN HIDROKLORIDA
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Surfaktan merupakan komponen yang mempengaruhi karakteristik niosom.
Kombinasi surfaktan akan menghasilkan niosom yang lebih baik dibandingkan
pemakaian surfaktan lipofilik tunggal. Tujuan dari penelitian ini adalah untuk
mengetahui pengaruh nilai HLB kombinasi surfaktan Tween 60 dan Span 60
terhadap stabilitas fisik niosom Glukosamin HCl. Niosom dibuat menggunakan
metode hidrasi lapis tipis dengan variasi nilai HLB 4,7 (F1), 6,15 (F2), 6,74 (F3),
dan 8,1 (F4). Pengujian stabilitas dilakukan pada suhu 4oC dan 40oC selama 8
minggu yang meliputi uji organoleptis, pH, bobot jenis, zeta potensial, ukuran
partikel, % PDI. Pada sistem niosom juga dilakukan pengujian morfologi dan
efisiensi penjerapan. Niosom yang dihasilkan merupakan sistem dengan partikel
berbentuk bulat dengan nilai efisiensi penjerapan 57,215 % (F1), 62,133 % (F2),
65,850 % (F3), dan 69,571 % (F4). Pada penyimpan suhu 4oC, niosom yang
dihasilkan berbentuk suspensi berwarna putih yang homogen, sedangkan pada
penyimpanan suhu 40oC, niosom mengalami perubahan warna menjadi coklat.
Rata-rata ukuran partikel niosom adalah 271,83 – 631,85 nm dengan zeta potensial
(-)36,67 – (-)63,94 mV, PDI 0,000,00 - 0,510,06 dan bobot jenis 1,006 – 1,045
g/mL. Variasi HLB kombinasi tween 60 dan span 60 tidak mempengaruhi stabilitas
fisik niosom pada penyimpanan suhu 4
oC dan 40oC.
Kata Kunci : Niosom, Tween 60, Stabilitas Fisik, Glukosamin HCl
date: 2022
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   AULIA, NURSYIDA dan Nining, Nining dan Amalia, Anisa  (2022) PENGARUH NILAI HLB KOMBINASI TWEEN 60 DAN SPAN 60 SEBAGAI SURFAKTAN TERHADAP STABILITAS FISIK NIOSOM GLUKOSAMIN HIDROKLORIDA.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/22291/1/FS03-220513.pdf