eprintid: 21980
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/19/80
datestamp: 2023-04-02 10:47:30
lastmod: 2023-04-02 10:47:30
status_changed: 2023-04-02 10:47:30
type: thesis
metadata_visibility: show
creators_name: Fadilah, Tiara Septia
creators_name: Sherley, Sherley
title: LITERATURE REVIEW: METABOLIT SEKUNDER, AKTIVITAS
ANTI-INFLAMASI, DAN IMUNOMODULATOR TANAMAN TEH
(Camellia sinensis L.)
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Camellia sinensis L. atau tanaman teh merupakan salah satu tanaman yang sering
dimanfaatkan masyarakat untuk dikonsumsi sebagai minuman dan dimanfaatkan
sebagai obat tradisional. Penelitian ini merupakan ulasan melalui studi Pustaka
menggunakan metode literature review dengan tujuan mengkaji penelitian terkait
metabolit sekunder, aktivitas anti-inflamasi, dan imunomodulator tanaman teh.
Hasil penelitian menunjukkan bahwa tanaman teh mengandung metabolit sekunder
yang berperan dalam aktivitas anti-inflamasi yaitu golongan flavonoid dan saponin,
sedangkan pada senyawa aktifnya yaitu katekin, epigallocatechin (EGC), dan 21-
O-angelyoltheasaponin. Metabolit sekunder yang memiliki peran dalam aktivitas
imunomodulator yaitu golongan fenol dan flavonoid. Tanaman teh memiliki
aktivitas anti-inflamasi dengan cara menghambat denaturasi protein, menghambat
hemolisis sel darah merah, menekan ekpresi gen proinflamasi, menghambat
produksi nitrit oksida (NO), dan laju inflamasi akibat induksi karagenan, croton oil,
dan dekstran. Tanaman teh memiliki aktivitas imunomodulator dengan
meningkatkan jumlah leukosit total dan antibodi, meningkatkan aktivitas
fagositosis makrofag, meningkatkan imunitas, dan mereduksi ekspresi IL-17A, IL8, serta HBD-2. Kesimpulan dari penelitian literature review ini bahwa tanaman
teh mengandung metabolit sekunder yang berkaitan dengan aktivitas farmakologi
yaitu anti-inflamasi dan imunomodulator.
Kata kunci: Metabolit Sekunder, Anti-inflamasi, Imunomodulator, Camellia
sinensis L.
date: 2022
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Fadilah, Tiara Septia dan Sherley, Sherley  (2022) LITERATURE REVIEW: METABOLIT SEKUNDER, AKTIVITAS ANTI-INFLAMASI, DAN IMUNOMODULATOR TANAMAN TEH (Camellia sinensis L.).  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21980/1/FS03-220461.pdf